Cytochrome P450 in Cancer Susceptibility and Treatment

Mittal, Balraj; Tulsyan, Sonam; Kumar, Surendra; Mittal, Rama Devi; Agarwal, Gaurav

doi:10.1016/bs.acc.2015.06.003

Cited by 93 publications

(84 citation statements)

References 305 publications

(333 reference statements)

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“…In contrast, the cancer-unrelated pCRT-response genes were significantly enriched in typical metabolism pathways related to drug metabolisms such as cytochrome P450 which contributes to multidrug resistance in tumor34 and other diseases35. Outstandingly, we found that the cancer-unrelated pCRT-response genes tend to interact with the known pharmacokinetic genes (See Fig.…”

Section: Discussionmentioning

confidence: 84%

Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers

Guo

Cheng

et al. 2016

Sci Rep

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For patients with locally advanced rectal cancer (LARC) treated with preoperation chemoradiation (pCRT), identifying differentially expressed (DE) genes between non-responders and responders is a common approach for investigating mechanisms of chemoradiation resistance. However, some of such DE genes might be irrelevant to cancer itself but simply reflect the pharmacokinetic differences of the normal tissues. In this study, we adopted the RankComp algorithm to identify DE genes for each of LARC sample compared with its own normal state. Then, we identified genes with significantly different deregulation frequencies between the non-responders and responders, defined as cancer-related pCRT-response genes. Pathway enrichment and protein-protein interaction analyses showed that these genes specifically and intensively interacted with currently known effective genes of pCRT, involving in DNA replication, cell cycle and DNA repair. In contrast, after excluding the cancer-related pCRT-response genes, the other DE genes between non-responders and responders were enriched in many pathways of drug and protein metabolisms and transports, and interacted with both the known effective genes and pharmacokinetic genes. Hence, these two types of DE genes should be distinguished for investigating mechanisms of pCRT response in LARCs.

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Section: Discussionmentioning

confidence: 84%

Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers

Guo

Cheng

et al. 2016

Sci Rep

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“…Cytochrome P450‐dependent monooxygenase (CYP450) is a group of enzymes of hemoproteins present in the smooth endoplasmic reticulum of cells . The main function of CYP450 is the oxidative catalysis and the metabolism of various endogenous and exogenous substances, including alcohols, aldehydes, and anticancer drugs .…”

Section: Genes Involved In the Metabolism Of Alcohols And Aldehydes mentioning

confidence: 99%

“…The main function of CYP450 is the oxidative catalysis and the metabolism of various endogenous and exogenous substances, including alcohols, aldehydes, and anticancer drugs . Numerous studies have shown the importance of the CYP450 gene and its alleles in the susceptibility to cancer . Because CYP450 is involved in the metabolism of steroid hormones, in particular hormones associated with breast and prostate cancer, the role of this gene in susceptibility to these diseases has been noted .…”

Section: Genes Involved In the Metabolism Of Alcohols And Aldehydes mentioning

confidence: 99%

Human Endogenous Formaldehyde as an Anticancer Metabolite: Its Oxidation Downregulation May Be a Means of Improving Therapy

Dorokhov

Sheshukova

Bialik³

et al. 2018

BioEssays

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Malignant cells are characterized by an increased content of endogenous formaldehyde formed as a by‐product of biosynthetic processes. Accumulation of formaldehyde in cancer cells is combined with activation of the processes of cellular formaldehyde clearance. These mechanisms include increased ALDH and suppressed ADH5/FDH activity, which oncologists consider poor and favorable prognostic markers, respectively. Here, the sources and regulation of formaldehyde metabolism in cancer cells are reviewed. The authors also analyze the participation of oncoproteins such as fibulins, FGFR1, HER2/neu, FBI‐1, and MUC1‐C in the control of genes related to formaldehyde metabolism, suggesting the existence of two mutually exclusive processes in cancer cells: 1) production and 2) oxidation and elimination of formaldehyde from the cell. The authors hypothesize that the study of the anticancer properties of disulfiram and alpha lipoic acid – which affect the balance of formaldehyde in the body – may serve as the basis of future anticancer therapy.

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“…On the other hand, women are also more frequently affected by autoimmune disease like multiple sclerosis and rheumatic disease [5,7]. Interestingly, cytochrome p450 isoforms, playing a critical role in drug metabolism and clinical effectiveness, are differentially expressed in female versus male patients [8,9]. Lately, an interconnectedness with epigenetics was reported in two independent in vitro studies [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Generally, a trend towards higher overall methylation in males was found and blood global long interspersed nuclear elements-1 (LINE-1) methylation is also significantly higher in males than in females [2,5,[7][8][9]26,27]. If the same is true in disease, whether this has an influence on the response to treatment and disease outcome needs to be further evaluated.…”

Section: Introductionmentioning

confidence: 99%

The Relevance of Gender in Tumor-Influencing Epigenetic Traits

et al. 2019

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Tumorigenesis as well as the molecular orchestration of cancer progression are very complex mechanisms that comprise numerous elements of influence and regulation. Today, many of the major concepts are well described and a basic understanding of a tumor's fine-tuning is given. Throughout the last decade epigenetics has been featured in cancer research and it is now clear that the underlying mechanisms, especially DNA and histone modifications, are important regulators of carcinogenesis and tumor progression. Another key regulator, which is well known but has been neglected in scientific approaches as well as molecular diagnostics and, consequently, treatment conceptualization for a long time, is the subtle influence patient gender has on molecular processes. Naturally, this is greatly based on hormonal differences, but from an epigenetic point of view, the diverse susceptibility to stress and environmental influences is of prime interest. In this review we present the current view on which and how epigenetic modifications, emphasizing DNA methylation, regulate various tumor diseases. It is our aim to elucidate gender and epigenetics and their interconnectedness, which will contribute to understanding of the prospect molecular orchestration of cancer in individual tumors.

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Cytochrome P450 in Cancer Susceptibility and Treatment

Cited by 93 publications

References 305 publications

Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers

Discriminating cancer-related and cancer-unrelated chemoradiation-response genes for locally advanced rectal cancers

Human Endogenous Formaldehyde as an Anticancer Metabolite: Its Oxidation Downregulation May Be a Means of Improving Therapy

The Relevance of Gender in Tumor-Influencing Epigenetic Traits

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