2013
DOI: 10.1002/jmv.23695
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Variability of the preC/C region of hepatitis B virus genotype A from a South African cohort predominantly infected with HIV

Abstract: Hepatitis B virus (HBV) is a serious global health problem, and HBV genotype is an important determinant of disease progression and treatment outcome. The aim of this study was to assess variations of the precore/core (preC/C) region in HBV genotype A. Sequencing of the preC/C and surface (S) genes of HBV was performed on plasma samples from 20 HBV/HIV co-infected and 5 HBV mono-infected individuals. All preC/C study sequences clustered with subgenotype A1, except for two which clustered with subgenotype D4 re… Show more

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Cited by 12 publications
(10 citation statements)
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“…The HBV genotype D is second to genotype A in terms of predominance in Southern Africa, with the dominant D subgenotype reported to be the D3 [20,29]. However, a recent South African study isolated the subgenotype D4 [26] as was the case in the current study, showing potential importation from other countries like Kenya [24] and Somalia [29] where the D4 subgenotype has been reported.…”
Section: Discussionmentioning
confidence: 51%
“…The HBV genotype D is second to genotype A in terms of predominance in Southern Africa, with the dominant D subgenotype reported to be the D3 [20,29]. However, a recent South African study isolated the subgenotype D4 [26] as was the case in the current study, showing potential importation from other countries like Kenya [24] and Somalia [29] where the D4 subgenotype has been reported.…”
Section: Discussionmentioning
confidence: 51%
“…HBV preC/C primers were used for nested HBV‐PCR as previously described . Sequencing was performed at Inqaba Biotechnical company using published preC/C primers and method …”
Section: Methodsmentioning
confidence: 99%
“…Within the continent, data on the prevalence of pc mutations in both HBV mono‐infected and HIV‐HBV co‐infected patients are certainly available . However, their implications with respect to virological and serological response during anti‐HBV NA therapy remain to be elucidated.…”
Section: Introductionmentioning
confidence: 99%
“…11 The pcG1896A mutation would then appear to impose serious consequences on the therapeutic course of NA-treated patients.Within the continent, data on the prevalence of pc mutations in both HBV mono-infected and HIV-HBV co-infected patients are certainly available. [12][13][14][15][16] However, their implications with respect to virological and serological response during anti-HBV NA therapy remain to be elucidated. In the study herein, we used unique data from a cohort of antiretroviral treatment (ART)-naïve HIV-HBV co-infected patients from Côte d'Ivoire initiating treatment with an anti-HBV containing regimen.…”
mentioning
confidence: 99%