Variability of Influenza AH1N1 Infections in a Neonatal Unit in Spain

Calvo, Cristina; González-Carrasco, Ersilia; Quevedo, Sergio; García-García, Maria Luz; Rando, Alvaro; Ledesma, Juan; Calderón, Ana Belén Mayo; Pozo, Francisco; Pérez-Breña, Pilar; Casas, Inmaculada

doi:10.1159/000324232

Cited by 3 publications

(3 citation statements)

References 19 publications

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“…Very little is known about their role in neonatal units, 4,5 although we have demonstrated that they are associated with relevant pathology in our unit. 6,7 Neonatal units devote considerable effort to set up measures to prevent infection, such as the use of hygiene measures of proved effectiveness by any staff that comes in contact with the infants: applying alcohol gel before and after manipulating the child, wearing gloves, frequent handwashing, prevention of catheter-related sepsis by monitoring the catheter and withdrawing it as early as possible, and the prudent use of antibiotics.…”

Section: Infecciones Virales De Las Vías Respiratorias En La Unidad Dmentioning

confidence: 99%

Viral respiratory tract infections in the neonatal intensive care unit

González-Carrasco

Calvo

García-García

et al. 2015

Anales de Pediatría (English Edition)

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Introduction: Viral respiratory infections cause major morbidity and mortality in preterm infants. We have performed a prospective study in our neonatal intensive care unit (NICU) to determine the incidence of respiratory infections, their impact and the epidemiology and outcome in high risk neonates. Patients and methods: From September 2011 to May 2013 a prospective study was conducted in all preterm infants <32 weeks gestational age and in all term newborns admitted to NICU for any pathology that was anticipated to have an admission exceeding two weeks. A nasopharyngeal aspirate (NPA) was collected the first day of life and weekly until discharge for virologic study with polymerase chain reaction. When these babies presented respiratory symptoms a new NPA was collected at this moment. A clinical form was filled by the physician. Results: A total of 60 infants were analysed: 30 (50%) had a gestational age <32 weeks and 36 (60%) weighed less than 1500 g. We collected a total of 256 nasopharyngeal aspirate samples, 24 of them being positive (9.3%). These 24 positive samples corresponded to 13 infants in our cohort (21.6% of the patients). Of them, 9 were symptomatic and had 11 episodes of infection (2 patients had two different episodes with negative control between them). The most frequently identified virus was rhinovirus in (19) 79% of cases. The most frequent clinical data was the presence or increase in apneas (75%) and the need for oxygenotherapy. Conclusions: HRV infections are prevalent in the NICU, and preterm infants have a high risk of infections with clinical relevance. ---el 79% de las muestras (19) ---fue el rinovirus (RV). El dato clínico más frecuente fue la presencia o incremento de apneas (75%) y la necesidad de oxigenoterapia. Conclusiones: Las infecciones por RV son frecuentes en la UCIN y los recién nacidos pretérmino tienen un alto riesgo de presentar infecciones de relevancia clínica.

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Section: Infecciones Virales De Las Vías Respiratorias En La Unidad Dmentioning

confidence: 99%

Viral respiratory tract infections in the neonatal intensive care unit

González-Carrasco

Calvo

García-García

et al. 2015

Anales de Pediatría (English Edition)

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“…Information about the prevalence of VRI in surveillance studies in NICUs varies from 2% to 55% among the screened infants, 1–4 and these studies have emphasized the importance of these viruses in the respiratory morbidity of the newborn. In addition to the classic viral outbreaks caused by respiratory syncytial virus (RSV) or influenza, 5,6 rhinovirus (hRV) or adenovirus (hAD) 1,4,7 are particularly relevant. hRV is the viral species causing VRI most frequently identified in preterm infants and associates increased respiratory support, longer hospital stay, and higher rates of bronchopulmonary dysplasia (BPD) 8,9 …”

Section: Introductionmentioning

confidence: 99%

Respiratory morbidity associated with viral respiratory infections during neonatal stage in premature infants

García

Pellicer

López-Martínez

et al. 2021

Pediatric Pulmonology

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Background and Objective Very low birth weight (VLBW) infants are highly susceptible to viral respiratory infections (VRIs), even during admission to the neonatal intensive care unit (NICU). Although the role of VRI in childhood in the development of recurrent wheezing and long‐term asthma is well known, information on the impact in later morbidity of VRI in the neonatal period is lacking. We aimed to explore the occurrence of recurrent wheezing over the first 2 years of life according to VRI status during NICU admission. Methods During April 2016 and December 2017, infants below 32 weeks of gestation were prospectively studied in VRI surveillance during NICU admission. Families were contacted between September 2018 and May 2019 by a telephone questionnaire. Results A total of 99 patients were enrolled. The mean gestational age and birth weight were 28.8 (1.9) weeks and 1118 (329) g, respectively. During the first 2 years of life, neither episodes of wheezing nor the respiratory impairment‐related hospital admissions differed between positive and negative VRI infants. Episodes of wheezing and respiratory impairment‐related hospital admissions, as well as specific respiratory treatment prescription, were more frequent within the first 2 years in infants who had suffered symptomatic VRI during NICU admission. Conclusion Symptomatic VRI in VLBW infants is associated with long‐term respiratory morbidity. The early surveillance of VRI in the preterm infant during NICU admission is justified for prognostic counseling and closely monitoring after discharge. Routine instruction on asthma‐related risk factors and early prescription of antiasthmatic treatments, when indicated, should be established.

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“…Además de los virus clásicos, como el VRS y los virus de la gripe, los rinovirus (RV), metapneumovirus humano (hMPV), coronavirus (CoV) y bocavirus humano (hBoV) desempeñan un papel cada vez más importante en las infecciones respiratorias de los lactantes. No se conoce prácticamente nada sobre su papel en unidades neonatales 4,5 , si bien nosotros hemos objetivado que se asocian con patología relevante en nuestra unidad 6,7 .…”

Section: Introductionunclassified