Viral respiratory tract infections in the neonatal intensive care unit

González-Carrasco, Ersilia; Calvo, Cristina; García-García, Maria Luz; Beato, Maite; Muñoz-Archidona, C.; Pozo, Francisco; Casas, Inmaculada

doi:10.1016/j.anpede.2015.03.007

Cited by 13 publications

(16 citation statements)

References 14 publications

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“…The role of viruses in nosocomial infection has become increasingly recognised, with several studies showing that 20 to 50% of very preterm infants, born at ≤ 32 weeks’ gestation, acquired a nosocomial infection with a respiratory virus during their birth hospitalisation, often in the absence of clinical indicators of respiratory illnesses [35–37]. The detection of asymptomatic respiratory viruses was associated with deleterious outcomes, such as prolonged hospitalisation, increased number of clinical deterioration events as well as a greater requirement and longer duration of supplemental oxygen and ventilatory support [33,34,36,37]. In addition, the risk of developing a BPD diagnosis was more than two-times higher among infants with detected respiratory viruses during their birth hospitalisation [36,37].…”

Section: Viral Infection In Preterm Infants During the Birth Hospitalmentioning

confidence: 99%

“…The detection of asymptomatic respiratory viruses was associated with deleterious outcomes, such as prolonged hospitalisation, increased number of clinical deterioration events as well as a greater requirement and longer duration of supplemental oxygen and ventilatory support [33,34,36,37]. In addition, the risk of developing a BPD diagnosis was more than two-times higher among infants with detected respiratory viruses during their birth hospitalisation [36,37]. Collectively, such findings may advocate for more comprehensive routine testing for respiratory viruses in preterm infants during the neonatal hospitalisation…”

Section: Viral Infection In Preterm Infants During the Birth Hospitalmentioning

confidence: 99%

“…The frequency of re-hospitalisation during the first year of life among preterm infants ranges from 6 to 50% [5,40–42] depending on the cohort studied. Young chronological age is the main predictor of infection-related morbidity among preterm infants, with studies reporting increased risk of infection, healthcare utilisation and hospital readmissions during the first 6 months of life [39,43,44].…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

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The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Section: Viral Infection In Preterm Infants During the Birth Hospitalmentioning

confidence: 99%

Section: Viral Infection In Preterm Infants During the Birth Hospitalmentioning

confidence: 99%

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

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The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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“…Therefore, it is plausible that VRTIs acquired during the NICU period could worsen BPD in preterm infants although previous studies have mostly been small observational studies 12,13,[15][16][17][18][19] . We aimed to assess the association between nosocomial VRTIs acquired in the NICU and respiratory morbidity up to hospital discharge.…”

Section: Introductionmentioning

confidence: 99%

Outcomes of Nosocomial Viral Respiratory Infections in High-Risk Neonates

et al. 2016

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A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription.For more information, please contact eprints@nottingham.ac.uk Financial disclosure: The other authors have no financial relationships relevant to this article to disclose. Outcomes of nosocomial viral respiratory infections in high-risk neonates Conflicts of interest:The other authors have no potential conflicts of interest to disclose. Abbreviations:VRTIs -viral respiratory tract infections BPD -bronchopulmonary dysplasia NICU -neonatal intensive care unit NEC -necrotising enterocolitis CPAP -continuous positive airway pressure Bi-PAP -bi-level positive airway pressure HFOV -high frequency ventilation ECMO -extracorporeal membrane oxygenation RT-PCR -real time polymerase chain reaction RVP -respiratory viral panel NHS -National Health Service What's Known on This SubjectViral respiratory tract infections cause severe respiratory morbidity in ex-preterm infants after NICU discharge. They are now recognized to be more prevalent in the NICU but their longterm impact, prior to discharge, during this early period of life is unclear. What This Study AddsThis study identifies the adverse impact viral respiratory infections, particularly rhinovirus, have on newborn infants during their initial NICU admission. Identification of the associated significant respiratory morbidity and healthcare costs should focus efforts on reducing these nosocomially acquired infections. Contributors' Statements:Dr Don Sharkey conceptualized and designed the study, drafted the initial manuscript, and approved the final manuscript as submitted.Drs Shairbanu Zinna, Arthi Lakshmanan, Shin Tan, Shiu Soo, Lisa Szatkowski and Miss Rebecca McClaughry and Mr Martin Clarkson carried out the data collection, initial analyses, reviewed and revised the manuscript, and approved the final manuscript as submitted.All authors approved the final manuscript as submitted and agree to be accountable for all aspects of the work. ABSTRACTBackground Neonatal respiratory disease, particularly bronchopulmonary dysplasia, remains one of the leading causes of morbidity and mortality in newborn infants. There is increasing evidence that nosocomially acquired viral respiratory tract infections (VRTIs) are not uncommon in the neonatal intensive care unit but there are few studies on their impact on neonatal respiratory outcomes and the associated healthcare costs. This study aimed to assess the association between nosocomial VRTI and neonatal respiratory disease.

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“…College Hospital de Londres, a montré que les atteintes respiratoires basses à rhinovirus étaient associées à des coûts de santé significativement supérieurs à ceux liés au RSV durant la 1ère année de vie[18]. Récemment une équipe espagnole a effectué une recherche virologique prospective dans une unité néonatale de soins intensifs à partir de prélèvements nasopharyngés réalisés hebdomadairement ou à l'occasion d'épisodes symptomatiques[19]. Vingt pour cent des nouveau-nés ont eu au moins un prélèvement positif, 70 % d'entre eux étaient symptomatiques (75 % apnées, 80 % oxygéno-dépendance) et les rhinovirus représentaient 80 % des virus identifiés.…”

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