Variability of Human Body Heat Conductivity in Population I. Methodological and Theoretical Approaches

Ibraimov, A. I.; Kazakova, A. K.; Moldotashev, I K; Sultanmuratov, M. T.; Abdyev, K. S.

doi:10.1080/09709274.2010.11906316

Cited by 7 publications

(17 citation statements)

References 5 publications

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“…As in the karyotype of the female mammals there is lack of the sex chromosome with a large block of HR, for example as Y chromosome with males, then it is possible that in the interest of the CT a considerable part of one of the two X-chromosomes with the female embryo is undergoing to heterochromatinization. This is proved by the physiological data on a relatively low heat conductivity of the female body in comparison with the males' one [28]; c) if compensation (double) dose of genes is an inevitable phenomenon for normal functioning of the mammals' genome, then why the inactivation of Bioinfo Publications genes on the homologous autosomes do not happen? The inactivation of autosomes was not found even in cases of trisomies; d) '...the mammalian X chromosome is not specialized for sex determination.…”

Section: Why Ncdnas?mentioning

confidence: 88%

“…Nobody challenges the role of ncDNAs in formation of nucleosomas and chromatin. At the present time extensively are discussed that nucleus of eukaryotic cells, nucleosomes, chromatin, mitotic chromosomes, chromosome bands, heterochromatin regions, multicellularity, differentiation of somatic cells, sex, thermoregulation, adaptation, and also human being's naked skin and large neocortex result mainly from the evolution of ncDNAs [11,[23][24][25][26][27][28][29]. It is difficult to imagine, that e.g.…”

Section: Why Ncdnas?mentioning

confidence: 99%

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Evolution Without Genes

Ibraimov¹,

Moldo²

2011

Int J Genet

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Abstract-Nowadays genes are claimed to explain almost everything that is somehow or another connected with manifestations of the biological life on the Earth, including evolution. It is now clear, however, that major incongruities exist and that there is only a weak relationship between biological complexity and the number of protein coding genes. The genome can be divided into two main sections, the coding (genes) and non coding portions. Non coding DNAs have been considered as non-functional DNA by many authors. And to determine which of them is the most important in evolution based on the input of genes and non coding DNAs into the origin of the basic forms of life and its diversity. Information about non coding DNAs as the main evolving component of the genome is presented. It is supposed that evolution has not stopped on DNA, which is transcribed into RNA which in turn is translated into proteins.

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Section: Why Ncdnas?mentioning

confidence: 88%

Section: Why Ncdnas?mentioning

confidence: 99%

Evolution Without Genes

Ibraimov¹,

Moldo²

2011

Int J Genet

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“…That CT may be related to inactivation of one X-chromosome in humans is evidenced by such fact as the relatively low level of the BHC in women compared to men at the population level (Ibraimov & Tabaldiev, 2007;Ibraimov et al, 2010a). This is probably due to the fact that the CC in interphase cells of women do not have the same density as CC in men.…”

Section: Cell Thermoregulation and Sexmentioning

confidence: 79%

“…Apparently, the physiological thermoregulation functions relatively independently from CT as evolutionally new adaptive system (Ibraimov & Tabaldiev, 2007;Ibraimov et al, 2010a). From our point of view, CT can be the missing link, which should fill the "gap" between the thermoregulation systems, functioning at the molecular level and the whole organism.…”

Section: Resultsmentioning

confidence: 99%

“…We believe that only a human and two apes, being, having in its genome besides C-heterochromatin an additional Q-heterochromatin, are holders of the highly BHC in the animal world Ibraimov et al, 2014a). The greater common cold susceptibility of male individuals may explain the relatively higher heat conductivity of their bodies, in comparison with the opposite sex representatives (Ibraimov & Tabaldiev, 2007;Ibraimov et al, 2010a). This is related to a well-known fact that the male karyotype has a Y chromosome that contains the largest block of Q-heterochromatin in the human genome.…”

Section: Experimental Verification Of the Cell Thermoregulation Hypotmentioning

confidence: 99%

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Cell Thermoregulation: Problems, Advances and Perspectives

Ibraimov¹

2017

JMBR

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Thermoregulation at organism level is the well-established fact. The question on possibility of thermoregulation at the cell level remains opened. Based on study of distribution of chromosomal heterochromatin regions (HRs) in various human populations, in norm and at some forms of pathology the hypothesis about thermoregulation existence at the cell level has been presented. The essence of hypothesis of cell thermoregulation (СТ) is elimination of the temperature difference between the nucleus and cytoplasm when the nucleus temperature becomes higher than the cytoplasm temperature. The nucleus, in contrast to the cytoplasm, cannot conduct heat directly in the extracellular space, from where the heat is taken by the circulating flow of sap, lymph and blood. Thus, the nucleus can conduct heat only in the cytoplasm. With this, the nucleus has two options for the dissipation of heat surplus: either by increasing its volume or increasing the heat conductivity of the nuclear envelope. As the first option is limited, and the second one is hampered because of thickness of the cell membranes, apparently the higher eukaryotes took advantage of the opportunity of a dense layer of peripheral condensed chromatin (CC) as heat conductor for a more efficient elimination of the temperature difference between the nucleus and cytoplasm. The СС localized between a nucleus and cytoplasm is made of different types of chromosomal HRs. For this reason, СС is subject to wide variability in population. Obviously, the density of the СС packing depends on the type and quantity of chromosomal HRs in its structure that can affect upon its heat-conducting ability. If the situation is this then we are entitled to expect a new type of variability with all consequences resulting from here.

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