Variability of Human Body Heat Conductivity in Population II. Diseases of Civilization

Ibraimov, A. I.; Kazakova, A. K.; Moldotashev, I K; Sultanmuratov, M. T.; Abdyev, K. S.

doi:10.1080/09709274.2010.11906323

Cited by 5 publications

(8 citation statements)

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“…Nobody challenges the role of ncDNAs in formation of nucleosomas and chromatin. At the present time extensively are discussed that nucleus of eukaryotic cells, nucleosomes, chromatin, mitotic chromosomes, chromosome bands, heterochromatin regions, multicellularity, differentiation of somatic cells, sex, thermoregulation, adaptation, and also human being's naked skin and large neocortex result mainly from the evolution of ncDNAs [11,[23][24][25][26][27][28][29]. It is difficult to imagine, that e.g.…”

Section: Why Ncdnas?mentioning

confidence: 99%

Evolution Without Genes

Ibraimov¹,

Moldo²

2011

Int J Genet

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Abstract-Nowadays genes are claimed to explain almost everything that is somehow or another connected with manifestations of the biological life on the Earth, including evolution. It is now clear, however, that major incongruities exist and that there is only a weak relationship between biological complexity and the number of protein coding genes. The genome can be divided into two main sections, the coding (genes) and non coding portions. Non coding DNAs have been considered as non-functional DNA by many authors. And to determine which of them is the most important in evolution based on the input of genes and non coding DNAs into the origin of the basic forms of life and its diversity. Information about non coding DNAs as the main evolving component of the genome is presented. It is supposed that evolution has not stopped on DNA, which is transcribed into RNA which in turn is translated into proteins.

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Section: Why Ncdnas?mentioning

confidence: 99%

Evolution Without Genes

Ibraimov¹,

Moldo²

2011

Int J Genet

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“…The greatest amount of Q-HRs, like in other previously examined populations, is located on autosomes 3 and 13 (more than half of all the Q-HRs), while the rest of the Q-HRs are more or less uniformly distributed on other Q-polymorphic autosomes, indicating, as we suppose, nonlocusspecificity of Q-HRs in the human genome [15][16][17][18]. Indeed, as can be seen from this Table, Q-HRs in obese individuals is encountered with an expected frequency on all the potentially Qpolymorphic autosomes [3]. Table 2: Q-HR frequencies in seven Q-polymorphic autosomes in obese females and in the control group.…”

Section: Resultsmentioning

confidence: 91%

“…By studying chromosomal Q-HRs variability in the human populations permanently living in various climatic-and-geographic conditions of Eurasia and Africa, in norm and pathology we have obtained the data indicating possible participation of chromosomal Q-HRs in cell thermoregulation (CT). We have checked this hypothesis on the level of human organism assuming that CT is the basis for heat conductivity of whole cell part of body [3,47].…”

Section: Discussionmentioning

confidence: 99%

“…Without contesting the importance of these studies, we have chosen a somewhat different approach to the search for biological markers predisposing to the development of obesity. It is based on studying the phenomenon of wide quantitative variability of chromosomal Q-HRs in the human genome in certain purely human pathologies [3]. The point is that quantitative Q-HRs variability only exists in man, though this type of constitutive heterochromatin is present in the genome of two other higher primates: Pan troglodytes and Gorilla gorilla [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

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Chromosomal Q-Heterochromatin Polymorphism in Patients with Alimentary Obesity

Ai¹

2015

Biol Med

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Variability of the amount of chromosomal Q-heterochromatin regions (Q-HRs) was studied in individuals with alimentary obesity and in controls from two ethnic groups living in Bishkek, Kyrgyzstan. It was shown that obese individuals differ from controls in the extremely low amount of Q-HRs in their genome. The question as to the possible role of the amount of Q-HRs in the genome in the susceptibility of man to the development of alimentary obesity is discussed.

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“…From the data obtained by us, of interest are the following results: 1) alcoholics have the lowest number of Q-HRs in their genome, and they do not differ from each other in all the quantitative characteristics of chromosomal QHRs variability despite their different ethnic affiliation; 2) in the genome of drug addicts the number of QHRs is significantly greater than in controls, especially in subjects abusing in strong alcoholic beverages (Ibraimov, 2016b;Ibraimov et al, 2010b).…”

Section: Experimental Verification Of the Cell Thermoregulation Hypotmentioning

confidence: 99%

Cell Thermoregulation: Problems, Advances and Perspectives

Ibraimov¹

2017

JMBR

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Thermoregulation at organism level is the well-established fact. The question on possibility of thermoregulation at the cell level remains opened. Based on study of distribution of chromosomal heterochromatin regions (HRs) in various human populations, in norm and at some forms of pathology the hypothesis about thermoregulation existence at the cell level has been presented. The essence of hypothesis of cell thermoregulation (СТ) is elimination of the temperature difference between the nucleus and cytoplasm when the nucleus temperature becomes higher than the cytoplasm temperature. The nucleus, in contrast to the cytoplasm, cannot conduct heat directly in the extracellular space, from where the heat is taken by the circulating flow of sap, lymph and blood. Thus, the nucleus can conduct heat only in the cytoplasm. With this, the nucleus has two options for the dissipation of heat surplus: either by increasing its volume or increasing the heat conductivity of the nuclear envelope. As the first option is limited, and the second one is hampered because of thickness of the cell membranes, apparently the higher eukaryotes took advantage of the opportunity of a dense layer of peripheral condensed chromatin (CC) as heat conductor for a more efficient elimination of the temperature difference between the nucleus and cytoplasm. The СС localized between a nucleus and cytoplasm is made of different types of chromosomal HRs. For this reason, СС is subject to wide variability in population. Obviously, the density of the СС packing depends on the type and quantity of chromosomal HRs in its structure that can affect upon its heat-conducting ability. If the situation is this then we are entitled to expect a new type of variability with all consequences resulting from here.

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Variability of Human Body Heat Conductivity in Population II. Diseases of Civilization

Cited by 5 publications

References 1 publication

Evolution Without Genes

Evolution Without Genes

Chromosomal Q-Heterochromatin Polymorphism in Patients with Alimentary Obesity

Cell Thermoregulation: Problems, Advances and Perspectives

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