Value of bone marrow examination in Hodgkin lymphoma: Report of three cases with review of literature

Kini, Jyoti R.; Suresh, Pooja K; Sinha, Ruchi; Sahu, Kausalya Kumari; Kumar, Suneet; Prasad, Krishna

doi:10.4103/0973-1482.103535

Cited by 5 publications

(9 citation statements)

References 6 publications

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“…BM necrosis and fibrosis were seen in one case each. BM necrosis and fibrosis are findings often associated with BM infiltration of Hl and, when present, should raise the suspicion of BM involvement in a given case (1,7,12 (10). all these data suggest that doing BM staging only in high risk patients might not be sufficient.…”

Section: Discussionmentioning

confidence: 89%

“…in our study, among cytopenias, thrombocytopenia and leucopenia were seen in Hl patients only when there was BM involvement. B symptoms and cytopenia were frequently associated with BM involvement in other studies as well (9,10,22).…”

Section: Resultsmentioning

confidence: 96%

“…Hence some authors have suggested that BM studies can be done in selected high risk cases alone (5,8,9). However, a controversy exists as few other authors suggest that BM should be done in all the adult cases (1,10). This study was done to detect the frequency and morphology of BM involvement in Hl, to study the association of BM involvement with various clinical and hematological parameters and to find whether BM involvement is restricted to certain high risk groups alone.…”

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confidence: 99%

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Clinicopathological features of bone marrow infiltration in hodgkin lymphoma. should bone marrow staging be done only in high risk patients?

Sudalaimuthu

Basu²

2017

TJPATH

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Objective: the frequency of bone marrow infiltration by Hodgkin lymphoma is low and varies from 3 to 18%. Hence there exists a dilemma whether bone marrow staging should be done only in the high risk cases. this study aims to study the clinicopathological features and the histomorphology of bone marrow infiltration by Hodgkin lymphoma. Material and Method:Bone marrow aspirates and biopsies from cases of Hodgkin lymphoma diagnosed between 2007 and 2015 were studied. immunohistochemistry with CD15 and CD30 were done in necessary cases. Bone marrow infiltration was correlated with various clinicopathological parameters.Results: ten of the 81 cases (12.3%) studied showed infiltration by Hodgkin lymphoma in the bone marrow biopsy sections. all the aspirates were negative. Bone marrow in the involved cases showed Reed-Sternberg cells and/or mononuclear Hodgkin cells positive for CD30 in a polymorphous inflammatory background. Cases of lymphocyte depleted subtype (66%) and those with leucopenia/ thrombocytopenia (100%) were frequently associated with bone marrow infiltration. B-symptoms, anemia and mixed cellularity were the other risk factors. However none of these risk factors were noted in two out of the ten cases with bone marrow infiltration.Conclusion: as the role of bone marrow aspirate is minimal in the staging of Hodgkin lymphoma, bone marrow biopsy should be the method of choice. immunohistochemistry helps in the doubtful cases. Bone marrow involvement was frequent but not confined to the high risk groups. Our findings suggest that bone marrow staging should not be restricted to the high risk cases alone.

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Section: Discussionmentioning

confidence: 89%

Section: Resultsmentioning

confidence: 96%

mentioning

confidence: 99%

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Clinicopathological features of bone marrow infiltration in hodgkin lymphoma. should bone marrow staging be done only in high risk patients?

Sudalaimuthu

Basu²

2017

TJPATH

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“…Pancytopenia is less common as compared to Monocytopenia and bicytopenia in MDS. In a study by Kini J et al on MDS patients, bicytopenia was the commonest finding [18]. Cryptococcal involvement of bone marrow is very rare.…”

Section: Discussionmentioning

confidence: 98%

Role of bone marrow aspiration and biopsy in elaborating the diagnosis of pancytopenia

Chandan

Giriyan

2018

Trop J Pathol Microbiol

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Background and Aims: Pancytopenia may be a manifestation of a wide variety of disorders which primarily or secondarily affects the bone marrow. Bone marrow failure syndromes and malignancies are serious and life threatening causes, but certain non-malignant conditions such as infection, and nutritional anemia are equally important. The severity of pancytopenia and the underlying pathology determine the implementation of correct management and prognosis. Materials and Methods: This was a prospective study conducted for a period of two years on 134 patients of pancytopenia. Detailed history, thorough clinical examination, complete hemogram, peripheral smear examination, reticulocyte count evaluation and bone marrow aspiration was performed in all cases. In addition, trephine biopsy was done in the same setting wherever indicated. Results: The age ranged from 15 to 75 years with a mean age of 30.9 years. The most common cause of pancytopenia was Megaloblastic anemia (37%) followed by Nutritional anemia (31%), aplastic anemia (9%) and Leukemia (1.75%). Majority (79%) of the patients had hyper cellular bone marrow followed by hypocellular (13%) and normal cellular marrow (8%). Conclusion: Elaborate hematological investigations and bone marrow examination, both, in correlation with clinical findings are vital for the diagnosis of pancytopenia. Bone marrow Aspiration and Trephine biopsy, complement each other in diagnosis of challenging cases

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“…In the present study none of the case of HL showed bone marrow. The results were compared with the results of study done by Bartl et al 30 in which BMI was reported in 10% of cases, Ellis et al 31 in which BMI was observed in 7.1% of cases, Marisavljevic et al 32 in which BMI was in 10.2% of cases, Howell et al 33 in which BMI was in 5.2% of cases, Kini et al 34 in which BMI was in 10% cases and Mondal et al 16 in which BMI was in 9.3% of cases. The present study was done on the limited number of 60 cases of lymphoma and out of these 60 cases only 7 cases were of HL.…”

Section: Bone Marrow Involvement In Hlmentioning

confidence: 84%

Analysis of Bone Marrow and Peripheral Blood Film findings in sixty diagnosed cases of Lymphoma

Goel¹,

Kaur²,

Bal³

2020

ACHR

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Lymphoma constituting 55.6% of hematological malignancy, its prognosis depends on the correct diagnosis and stage of the disease, which is established after examination of peripheral blood film (PBF), bone marrow aspiration (BMA) and bone marrow biopsy (BMB) along with other parameters. Objective: The objective is to find out the percentage and pattern of bone marrow involvement, along with peripheral blood changes in lymphoma. Material and Methods: PBF, BMA and BMB findings studied in 60 lymphoma patients during a period of 3 years. The PBF and aspiration smears stained with Leishmann's stain, while the trephine biopsy processed and stained with Haematoxylin and eosin (H & E) stain and Reticulin stain. The results were scrutinized, compared and evaluated. Results: The male to female ratio was 1.4:1, including 53(88.3%) cases of NHL and 7(11.7%) cases of HL. Most common age group involved in NHL was 51-60 years and in HL was 31-40 years. 19/60 (31.7%) cases showed leucocytic lymphocytosis on PBF examination. Percentage lymphocytes in marrow differential count was increased in 16(26.7%) cases and were reported with bone marrow involvement on BMA and BMB and 1 case having borderline percentage lymphocyte count on BMA was reported as bone marrow involved case, only after examining the BMB. The diffuse pattern of involvement was most common in 7(41.2%), followed by paratrabecular pattern in 6(35.3%) cases. Conclusion: Thus to conclude bone marrow examination give valuable information in lymphoma, about disease burden, percentage of involvement, pattern of involvement and baseline involvement prior to therapy.

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Value of bone marrow examination in Hodgkin lymphoma: Report of three cases with review of literature

Cited by 5 publications

References 6 publications

Clinicopathological features of bone marrow infiltration in hodgkin lymphoma. should bone marrow staging be done only in high risk patients?

Clinicopathological features of bone marrow infiltration in hodgkin lymphoma. should bone marrow staging be done only in high risk patients?

Role of bone marrow aspiration and biopsy in elaborating the diagnosis of pancytopenia

Analysis of Bone Marrow and Peripheral Blood Film findings in sixty diagnosed cases of Lymphoma

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