Value and Significance of SCE in Human Leukemia and Cancer

Sandberg, Avery A.; Becher, R.; Gibas, Zenon

doi:10.1007/978-1-4684-4892-4_24

Cited by 3 publications

(1 citation statement)

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“…In the presence of bromodeoxyuridine, a halogenic analog of uridine, this can be detected in c-metaphase complements as an SCE. It is well documented that any increase in the frequency of SCE in an individual is linked to ill health [Sandberg et al, 1984]. SCE frequencies from two sets of experiments were scored in HPBLs of six (3 þ 3) healthy, nonsmoking male blood donors matched for age, lifestyle, occupational history, medical history, and diet.…”

Section: Introductionmentioning

confidence: 99%

Elevated sister chromatid exchange frequencies in dividing human peripheral blood lymphocytes exposed to 50 Hz magnetic fields

Wahab

Podd

Rapley³

et al. 2006

Bioelectromagnetics

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The in vitro cytomolecular technique, sister chromatid exchange (SCE), was applied to test the clastogenic potentiality of extremely low frequency (ELF) electromagnetic fields (EMFs) on human peripheral blood lymphocytes (HPBLs). SCE frequencies were scored in dividing peripheral blood lymphocytes (PBLs) from six healthy male blood donors in two rounds of experiments, R1 and R2, to determine reproducibility. Lymphocyte cultures in the eight experiments conducted in each round were exposed to 50 Hz sinusoidal (continuous or pulsed) or square (continuous or pulsed) MFs at field strengths of 1 microT or 1 mT for 72 h. A significant increase in the number of SCEs/cell in the grouped experimental conditions compared to the controls was observed in both rounds. The highest SCE frequency in R1 was 10.03 for a square continuous field, and 10.39 for a square continuous field was the second highest frequency in R2. DNA crosslinking at the replication fork is proposed as a model which could explain the mechanistic link between ELF EMF exposure and increased SCE frequency.

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Section: Introductionmentioning

confidence: 99%