Sister chromatid exchange frequency in breast cancer cases

Husain, Syed Akhtar; Balasubramanian, S.; Bamezai, R.

doi:10.1016/0165-4608(92)90077-l

Cited by 12 publications

(4 citation statements)

References 12 publications

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“…Although it has been argued that the increase in the frequency of SCE results from daily cigarette consumption not drugs, it is important to examine the factors causing SCE in detail. However, it is also intriguing that analyses of the patients from whom tumor was removed through surgical operation revealed a signifi cant decrease in the frequency of sister chromatid exchange (Aristei et al, 2009;Dhillon et al, 1995;Dhillon et al, 1996;Husain et al, 1992;Salah et al, 2011;Sardaş et al, 1994). As a result of the research on breast and other cancers, having a signifi cant relationship between the emergence and development of the tumor and SCEs confirmed these results.…”

Section: Discussionsupporting

confidence: 69%

Sister chromatid exchanges in breast cancer patients who underwent chemotherapy

2012

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-The study aimed to determine the effects of cytostatic and genotoxic drugs used to treat breast cancer on sister chromatid exchange (SCE). SCE values were examined in 25 female patients with breast cancer in pre-treatment, treatment process and remission period as well as in 22 nonsmoker women via peripheral blood culture technique. The SCE values of patient and control group were analyzed via "Mann-Whitney U test". Whilst SCE values of patient group were 8.25 ± 3.67, 10.19 ± 2.95 and 11.52 ± 3.33 in pre-treatment, treatment process and remission periods respectively, it was 7.01 ± 1.24 in control group. When overall SCE values of patients group in pre-treatment period were compared with those of control group, no significant difference was observed (p > 0.05), whereas highly significant differences were observed between treatment process and remission period of patient groups and control group in terms of SCE values (p < 0.01). If patients are exposed to any cytostatic and clastogenic drugs, the increase in the exchange values was considered remarkable. These findings reinforced the availability of sister chromatid exchange technique in directing of treatment and monitoring the genetic abnormalities caused by genomic instability which may occur due to the drugs used for treatment.

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Section: Discussionsupporting

confidence: 69%

Sister chromatid exchanges in breast cancer patients who underwent chemotherapy

2012

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“…Thē uctuation of SCE frequencies in peripheral blood lymphocytes observed in our study seems to fall within the normal range (from three to 11 SCE per cell in different laboratories) (Husain and Bamezai 1988), con®rming previous observations which suggest the lack of a quantitative correlation between handling of antineoplastic drugs and SCE frequency (Barale et al 1985;Ensslin et al 1997). An increment in the SCE rate was observed in patients with newly diagnosed breast cancer (Husum et al 1981;Livingston et al 1983;Husain et al 1992;Dhillon et al 1995). However, in one study, the rate of SCE decreased following surgical removal of a tumor.…”

Section: Discussionmentioning

confidence: 87%

Somatic mutations at the T-cell antigen receptor in antineoplastic drug-exposed populations: comparison with sister chromatid exchange frequency

Lanza

Cuna

Zibera

et al. 1999

International Archives of Occupational and Environmental Health

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“…1 B and C). In mammalian cells, the frequency of strand exchange correlates quite directly with genomic instability, cell death, and carcinogenic transformation and, in fact, is often used as a diagnostic and prognostic marker in cancer patients (10)(11)(12)(13). Thus, whereas the role of recombination is quite clear in reproductive cycles that tolerate variations among the quantity or genetic makeup of the progeny, when recombination occurs during asexual reproductive cycles the effects often appear to be detrimental.…”

Section: G Enetic Recombination Is Universal To All Organisms and It Ismentioning

confidence: 99%

Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination

Courcelle

Hanawalt

2001

Proc. Natl. Acad. Sci. U.S.A.

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Alternative reproductive cycles make use of different strategies to generate different reproductive products. In Escherichia coli, recA and several other rec genes are required for the generation of recombinant genomes during Hfr conjugation. During normal asexual reproduction, many of these same genes are needed to generate clonal products from UV-irradiated cells. However, unlike conjugation, this latter process also requires the function of the nucleotide excision repair genes. Following UV irradiation, the recovery of DNA replication requires uvrA and uvrC, as well as recA, recF, and recR. The rec genes appear to be required to protect and maintain replication forks that are arrested at DNA lesions, based on the extensive degradation of the nascent DNA that occurs in their absence. The products of the recJ and recQ genes process the blocked replication forks before the resumption of replication and may affect the fidelity of the recovery process. We discuss a model in which several rec gene products process replication forks arrested by DNA damage to facilitate the repair of the blocking DNA lesions by nucleotide excision repair, thereby allowing processive replication to resume with no need for strand exchanges or recombination. The poor survival of cellular populations that depend on recombinational pathways (compared with that in their excision repair proficient counterparts) suggests that at least some of the rec genes may be designed to function together with nucleotide excision repair in a common and predominant pathway by which cells faithfully recover replication and survive following UV-induced DNA damage.

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Sister chromatid exchange frequency in breast cancer cases

Cited by 12 publications

References 12 publications

Sister chromatid exchanges in breast cancer patients who underwent chemotherapy

Sister chromatid exchanges in breast cancer patients who underwent chemotherapy

Somatic mutations at the T-cell antigen receptor in antineoplastic drug-exposed populations: comparison with sister chromatid exchange frequency

Participation of recombination proteins in rescue of arrested replication forks in UV-irradiated Escherichia coli need not involve recombination

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