Valorizing a hydrothermal liquefaction aqueous phase through co-production of chemicals and lipids using the oleaginous yeast Yarrowia lipolytica

Cordova, Lauren T.; Lad, Beena C.; Ali, Sabah A.; Schmidt, Andrew J.; Billing, Justin M.; Pomraning, Kyle R.; Hofstad, Beth A.; Swita, Marie; Collett, James R.; Alper, Hal S.

doi:10.1016/j.biortech.2020.123639

Cited by 32 publications

(12 citation statements)

References 44 publications

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“…Since hemicellulose and lignin are acetylated [ 20 , 82 ], acetic acid is frequently present in lignocellulosic biomass hydrolysates at concentrations that can reach toxic values [ 83 , 84 , 85 , 86 ] being considered one of the major inhibitory compounds in lignocellulosic biomass hydrolysates. However, several strategies were developed to minimise the toxic effect of acetic acid, either by implementing a pretreatment that tackles the deacetylation and mechanical refining (DMR) or by the conversion of acetate directly into lipids [ 87 ] or co-products [ 88 ]. For its importance, the role of acetic acid in this context is detailed in Section 4.3 .…”

Section: Production Of Yeast Oils From Lignocellulosic Biomass Hydrol...mentioning

confidence: 99%

Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues

Mota

Múgica²,

Correia

2022

JoF

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Exploration of yeast diversity for the sustainable production of biofuels, in particular biodiesel, is gaining momentum in recent years. However, sustainable, and economically viable bioprocesses require yeast strains exhibiting: (i) high tolerance to multiple bioprocess-related stresses, including the various chemical inhibitors present in hydrolysates from lignocellulosic biomass and residues; (ii) the ability to efficiently consume all the major carbon sources present; (iii) the capacity to produce lipids with adequate composition in high yields. More than 160 non-conventional (non-Saccharomyces) yeast species are described as oleaginous, but only a smaller group are relatively well characterised, including Lipomyces starkeyi, Yarrowia lipolytica, Rhodotorula toruloides, Rhodotorula glutinis, Cutaneotrichosporon oleaginosus and Cutaneotrichosporon cutaneum. This article provides an overview of lipid production by oleaginous yeasts focusing on yeast diversity, metabolism, and other microbiological issues related to the toxicity and tolerance to multiple challenging stresses limiting bioprocess performance. This is essential knowledge to better understand and guide the rational improvement of yeast performance either by genetic manipulation or by exploring yeast physiology and optimal process conditions. Examples gathered from the literature showing the potential of different oleaginous yeasts/process conditions to produce oils for biodiesel from agro-forestry and industrial organic residues are provided.

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Section: Production Of Yeast Oils From Lignocellulosic Biomass Hydrol...mentioning

confidence: 99%

Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues

Mota

Múgica²,

Correia

2022

JoF

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“…As an example, oleaginous strains such as Yarrowia lipolytica advantages compared to high innate lipogenesis potential (Miller and Alper, 2019). As a robust oleaginous yeast, it has been well studied to produce biofuels and other chemicals derived from fatty acids (Liu et al, 2015;Cordova et al, 2020). Additionally, it has been shown to have a high tolerance to a variety of organic compounds, elevated salt concentrations, pH levels, the presence of ionic liquids, heavy metals, salts, and other pollutants (aromatic, nitro, and halogenated hydrocarbons, organophosphates) making it epitome for waste valorization (Cordova et al, 2020).…”

Section: Sargassum For Biodiesel Productionmentioning

confidence: 99%

“…As a robust oleaginous yeast, it has been well studied to produce biofuels and other chemicals derived from fatty acids (Liu et al, 2015;Cordova et al, 2020). Additionally, it has been shown to have a high tolerance to a variety of organic compounds, elevated salt concentrations, pH levels, the presence of ionic liquids, heavy metals, salts, and other pollutants (aromatic, nitro, and halogenated hydrocarbons, organophosphates) making it epitome for waste valorization (Cordova et al, 2020). It is awaited that similar approaches may be feasible with high volumes of Sargassum-based biomass.…”

Section: Sargassum For Biodiesel Productionmentioning

confidence: 99%

Opportunities Surrounding the Use of Sargassum Biomass as Precursor of Biogas, Bioethanol, and Biodiesel Production

et al. 2022

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Climate change (along with other factors) has caused an increase in the proliferation of brown algal mats floating freely along the Atlantic Ocean since 2011. These brown algae mats are composed of sea plants from the Sargassum genus. The gargantuan agglomeration of biomass flows alongside currents and lands in beaches belonging to the Eastern coasts of the Mexican Caribbean and several other countries in the region. These events, dubbed golden tides, harm the local economy and environment. Current elimination approaches involve the mechanical harvesting of the Sargassum and ultimate landfill disposal. However, explorations into the commercial application of other brown algae have elucidated the potential of Sargassum as a feedstock for valorization. This review informs the trends, challenges, and opportunities presented by the coastal invasion of this biomass. Primarily, the potential use of this material is as a precursor in biorefineries where multiple value-added products are generated concurrent with the ultimate production of biofuels.

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“…Microbial valorization will require either reducing toxicity through pretreatments (such as air stripping and solvent extraction) or improving tolerance by selecting a host strain more tolerant to HTL-AP. The latter was demonstrated using a metabolically engineered Y. lipolytica where HTL-AP was valorized into either triacetic acid lactone (TAL) or itaconic acid (Cordova et al., 2020 ) (Table 1 ). In defined media, the addition of 10% HTL-AP actually improved both TAL and itaconic acid titer.…”

Section: Other Industrial Wastesmentioning

confidence: 99%

Microbial valorization of underutilized and nonconventional waste streams

Lad

Coleman

Alper

2021

Journal of Industrial Microbiology and Biotechnology

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The growing burden of waste disposal coupled with natural resource scarcity has renewed interest in the remediation, valorization and/or repurposing of waste. Traditional approaches such as composting, anaerobic digestion, use in fertilizers or animal feed, or incineration for energy production extract very little value out of these waste streams. In contrast, waste valorization into fuels and other biochemicals via microbial fermentation is an area of growing interest. In this review, we discuss microbial valorization of nonconventional, aqueous waste streams such as food processing effluents, wastewater streams, and other industrial wastes. We categorize these waste streams as carbohydrate-rich food wastes, lipid-rich wastes, and other industrial wastes. Recent advances in microbial valorization of these nonconventional waste streams are highlighted, along with a discussion of the specific challenges and opportunities associated with impurities, nitrogen content, toxicity, and low productivity.

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Valorizing a hydrothermal liquefaction aqueous phase through co-production of chemicals and lipids using the oleaginous yeast Yarrowia lipolytica

Cited by 32 publications

References 44 publications

Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues

Exploring Yeast Diversity to Produce Lipid-Based Biofuels from Agro-Forestry and Industrial Organic Residues

Opportunities Surrounding the Use of Sargassum Biomass as Precursor of Biogas, Bioethanol, and Biodiesel Production

Microbial valorization of underutilized and nonconventional waste streams

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