Validity of a Short Functioning Test (FAST) in Brazilian Outpatients with Bipolar Disorder

Cacilhas, Alice Aita de; Magalhães, Pedro Vieira da Silva; Ceresér, Keila Maria Mendes; Walz, Julio Cesar; Weyne, Fernanda; Rosa, Adriane Ribeiro; Vieta, Eduard; Kapczinski, Flávio

doi:10.1111/j.1524-4733.2008.00481.x

Cited by 75 publications

(64 citation statements)

References 18 publications

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“…The participants are administered a questionnaire assessing domains of activities in daily living, using the Functioning Assessment Short Test (FAST) (56, 57). The FAST scale consists of 24 items and has been developed for the clinical evaluation of the main difficulties in daily functioning presented by psychiatric patients, particularly, bipolar disorder patients.…”

Section: Clinical Self-report and Cognitive Assessmentsmentioning

confidence: 99%

Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder – Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study)

Baune

Air

2016

Front. Psychiatry

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Cross-sectional and longitudinal studies exploring clinical, functional, and biological correlates of major depressive disorder are frequent. In this type of research, depression is most commonly defined as a categorical diagnosis based on studies using diagnostic instruments. Given the phenotypic and biological heterogeneity of depression, we chose to focus the phenotypic assessments on three cognitive dimensions of depression including (a) cognitive performance, (b) emotion processing, and (c) social cognitive functioning. Hence, the overall aim of the study is to investigate the long-term clinical course of these cognitive dimensions in depression and its functional (psychosocial) correlates. We also aim to identify biological “genomic” correlates of these three cognitive dimensions of depression. To address the above overall aim, we created the Cognition and Mood Study (CoFaMS) with the key objective to investigate the clinical, functional, and biological correlates of cognitive dimensions of depression by employing a prospective study design and including a healthy control group. The study commenced in April 2015, including patients with a primary diagnosis of a major depressive episode of major depressive disorder or bipolar disorder according to DSM-IV-TR criteria. The assessments cover the three cognitive dimensions of depression (cognitive performance, emotion processing, and social cognition), cognitive function screening instrument, plus functional scales to assess general, work place, and psychosocial function, depression symptom scales, and clinical course of illness. Blood is collected for comprehensive genomic discovery analyses of biological correlates of cognitive dimensions of depression. The CoFaM-Study represents an innovative approach focusing on cognitive dimensions of depression and its functional and biological “genomic” correlates. The CoFaMS team welcomes collaborations with both national and international researchers.

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Section: Clinical Self-report and Cognitive Assessmentsmentioning

confidence: 99%

Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder – Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study)

Baune

Air

2016

Front. Psychiatry

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“…22 The scale covers six specific areas of psychosocial functioning: autonomy, occupational functioning, cognitive functioning, financial issues, interpersonal relationships, and leisure time. The FAST has been validated for use both in the Brazilian population 23 and in patients with BD, 22 and has been reported to be sensitive to change.…”

Section: Assessmentmentioning

confidence: 99%

Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls

Vasconcelos-Moreno

Bücker

Bürke

et al. 2016

Rev. Bras. Psiquiatr.

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Objective: To assess cognitive performance and psychosocial functioning in patients with bipolar disorder (BD), in unaffected siblings, and in healthy controls. Methods: Subjects were patients with BD (n=36), unaffected siblings (n=35), and healthy controls (n=44). Psychosocial functioning was accessed using the Functioning Assessment Short Test (FAST). A sub-group of patients with BD (n=21), unaffected siblings (n=14), and healthy controls (n=22) also underwent a battery of neuropsychological tests: California Verbal Learning Test (CVLT), Stroop Color and Word Test, and Wisconsin Card Sorting Test (WCST). Clinical and sociodemographic characteristics were analyzed using one-way analysis of variance or the chi-square test; multivariate analysis of covariance was used to examine differences in neuropsychological variables.

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“…35 FAST is a valid instrument for evaluation of functioning in patients with BD. 30,31 However, it poses some limitations, such as the limited number of questions and the fact it is rated by a clinician. Another major limitation is that, as all patients were experiencing a depressive episode, their depressive symptoms may have affected vigilance and engagement during the cognitive assessment, thus impairing cognitive performance.…”

Section: Discussionmentioning

confidence: 99%

“…This instrument was developed to evaluate functional impairment and has been validated in patients with BD, showing excellent testretest reliability and internal consistency, with a Cronbach's alpha coefficient of 0.95 for the whole scale and excellent test-retest agreement for total FAST scores (r = 0.90; p o 0.001). 30,31 Previous studies have shown that patients with BD have lower FAST functioning scores compared with healthy controls, and that functional impairment is age-related in patients with BD. 31 …”

Section: Assessmentmentioning

confidence: 99%

Cognition and functioning in bipolar depression

Kapczinski

Narvaez

Magalhães

et al. 2016

Rev. Bras. Psiquiatr.

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Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and education level. Cognitive function was assessed with a neuropsychological test battery. Functioning was assessed with the Functioning Assessment Short Test. Results: In patients, severe depression was associated with poorer cognitive performance on measures of executive function. Patients with severe depression showed worse global functioning than those with moderate depression (z = 2.54, p = 0.011). In patients with severe depression, lower global functioning was associated with lower scores in working memory (r = -0.200, p = 0.010), and executive function (r = -0.210, p = 0.007; and r = 0.293, p o 0.001). Conclusion: Our findings suggest cognitive impairment and global functioning impairment are associated with the severity of depressive symptoms in bipolar depression. Intensive treatment of depressive symptoms in patients with BD is crucial to improve cognitive functioning and, consequently, functional outcomes.

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Validity of a Short Functioning Test (FAST) in Brazilian Outpatients with Bipolar Disorder

Abstract: The FAST is a measure with sufficient validity and reliability, with potential for the use in international clinical trials and comparative studies.

Cited by 75 publications

References 18 publications

Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder – Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study)

Clinical, Functional, and Biological Correlates of Cognitive Dimensions in Major Depressive Disorder – Rationale, Design, and Characteristics of the Cognitive Function and Mood Study (CoFaM-Study)

Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls

Cognition and functioning in bipolar depression

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