Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls

Vasconcelos-Moreno, Mirela Paiva; Bücker, Joana; Bürke, Kelen Patrícia; Czepielewski, Letícia Sanguinetti; Santos, Bárbara Tietbohl Martins Quadros dos; Fijtman, Adam; Passos, Ives Cavalcante; Kunz, Maurício; Bonnín, Caterina del Mar; Vieta, Eduard; Kapczinski, Flávio; Rosa, Adriane Ribeiro; Kauer-Sant’Anna, Márcia

doi:10.1590/1516-4446-2015-1868

Cited by 14 publications

(5 citation statements)

References 38 publications

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“…Among the verbal memory subtests, total and short delay free recall were most sensitive to IR. This pattern of verbal memory alterations among euthymic BD participants with IR was generally in keeping with the patterns of alterations in euthymic/subsyndromal BD participants (Cardoso et al, 2016;Chepenik et al, 2012;Martínez-Arán et al, 2004;Sumiyoshi et al, 2017;Vasconcelos-Moreno et al, 2016). In addition, among the CVLT subtests, total immediate recall is most strongly associated with lower hippocampal volumes in BD (Chepenik et al, 2012).…”

Section: Discussionsupporting

confidence: 74%

Insulin resistance is associated with verbal memory impairment in bipolar disorders

Salvi

Salvo

Korčáková

et al. 2020

Journal of Affective Disorders

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Section: Discussionsupporting

confidence: 74%

Insulin resistance is associated with verbal memory impairment in bipolar disorders

Salvi

Salvo

Korčáková

et al. 2020

Journal of Affective Disorders

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“…Study designs were all cross‐sectional (including one validation study). Three studies 34,37,38 included samples composed only of BD‐I patients; the other 10 studies reported data on mixed BD samples (composed of type I, type II and/or not otherwise specified). The sample size mostly varied between 12 and 150 individuals, with only one study having a large sample of 241 individuals, 39 thus differing from the others.…”

Section: Resultsmentioning

confidence: 99%

Functioning in euthymic patients with bipolar disorder: A systematic review and meta‐analysis using the Functioning Assessment Short Test

2020

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Objectives Systematically review the prevalence of functional impairment (FI) in euthymic patients with bipolar disorder (BD), as assessed only with the Functioning Assessment Short Test (FAST), explore the prevalence of this impairment among all the domains, identify the most compromised of them and the clinical variables associated with low functioning in this population. Methods Meta‐analyses were performed, searching for relevant papers published from 2007 to 2019 in Medline, Embase, Cochrane, PsycINFO databases and via hand‐searching, without language restrictions. 1128 studies were initially identified, 13 of which were ultimately chosen based on the eligibility criteria. A two‐step meta‐analysis was performed using the mean difference with a 95% confidence interval for continuous variables and proportion estimation with a fixed‐effects model for categorical variables. Results In the first step, all FAST domains showed worse FI in patients than in healthy controls, with significant differences between groups. In the second step, the prevalence of FI domains were as follows: global, 58.6%; occupational, 65.6%; cognitive, 49.2%; autonomy, 42.6%; interpersonal relationships, 42.1%; leisure, 29.2%; and financial issues, 28.8%. Residual depressive symptoms were the most frequently cited variable associated with FI. Conclusions This study reinforces the relevant functional impact of BD in this population and suggests that the occupational domain may be the most impaired. Greater efforts should be directed toward targeting functioning in patient care, as it constitutes the most meaningful endpoint of response to treatment, especially with occupational and cognitive rehabilitation, thus allowing patients to overcome the course of illness and carry fulfilling lives.

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“…We have in a clinical study including 234 twins shown that healthy twins with a co-twin with bipolar or unipolar disorder present with a lower education level and work position and tendency toward being more often unemployed and early retired compared with control twins without any first-degree relatives with severe mental illness (Christensen, Kyvik, & Kessing, 2006). Furthermore, a recent small study of middle-aged patients with bipolar disorder ( N = 33), their unaffected siblings ( N = 35) and healthy controls ( N = 43) showed that psychosocial functioning in unaffected offspring of patients with bipolar disorder was decreased compared with healthy control persons without psychiatric family history (Vasconcelos-Moreno et al, 2016). Educational achievement in unaffected siblings to patients with bipolar disorder has been investigated in a single study, only.…”

Section: Discussionmentioning

confidence: 99%

Socio-economic functioning in patients with bipolar disorder and their unaffected siblings – results from a nation-wide population-based longitudinal study

Sletved¹,

Ziersen²,

Andersen³

et al. 2021

Psychol. Med.

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Background Few studies have reported real-life data on socio-economic functioning in patients with bipolar disorder and their unaffected first-degree relatives. Methods We used Danish nation-wide population-based longitudinal register linkage to investigate socio-economic functioning in 19 955 patients with bipolar disorder, their 13 923 siblings and 20 sex, age and calendar-matched control individuals from the general population. Follow-up was from 1995 to 2017. Results Patients with a diagnosis of bipolar disorder had lower odds of having achieved the highest educational level [OR 0.75 (95% confidence interval (CI) 0.73–0.77)], being employed [OR 0.16 (95% CI 0.159–0.168)], having achieved the 80% highest quartile of income [OR 0.33 (95% CI 0.32–0.35)], cohabitating [OR 0.44 (95% CI 0.43–0.46)] and being married [OR 0.54 (95% CI 0.52–0.55)] at first contact to hospital psychiatry as inpatient or outpatient compared with control individuals from the general population. Similarly, siblings to patients with bipolar disorder had a lower functioning within all five socio-economic areas than control individuals. Furthermore, patients and partly siblings showed substantially decreased ability to enhance their socio-economic functioning during the 23 years follow-up compared to controls. Conclusions Socio-economic functioning is substantially decreased in patients with bipolar disorder and their siblings and does not improve during long-term follow-up after the initial hospital contact, highlighting a severe and overlooked treatment gap.

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Cognitive performance and psychosocial functioning in patients with bipolar disorder, unaffected siblings, and healthy controls

Cited by 14 publications

References 38 publications

Insulin resistance is associated with verbal memory impairment in bipolar disorders

Insulin resistance is associated with verbal memory impairment in bipolar disorders

Functioning in euthymic patients with bipolar disorder: A systematic review and meta‐analysis using the Functioning Assessment Short Test

Socio-economic functioning in patients with bipolar disorder and their unaffected siblings – results from a nation-wide population-based longitudinal study

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