2016
DOI: 10.1590/1516-4446-2014-1558
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Abstract: Objectives: Depressive symptoms are associated with worse outcomes in patients with bipolar disorder (BD). However, scarce data are available regarding neurocognitive profiles across different areas of functioning among BD patients with moderate and severe depression. Our objective was to assess cognition and global functioning in a group of patients with bipolar depression. Methods: Data were available for 100 patients with bipolar depression (78% female) and 70 controls (64% female) paired by age and educati… Show more

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Cited by 24 publications
(21 citation statements)
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“…These studies used the FAST to determine correlations between psychosocial functioning and clinical variables (eg, symptoms, number of hospitalizations, number of episodes, duration of illness, trait‐impulsivity, neurologic soft signs), emotion processing, cognitive functioning (eg, verbal learning and memory, visual memory, executive function, perceived cognitive performance), social cognition, sleep disturbances, or demographic variables or to assess overall and domain‐specific functioning in different mood states . The sixth study that used only the FAST to assess psychosocial functioning compared overall functioning in healthy controls and patients with BP‐I or BP‐II and assessed the relationship to cognitive functioning and depression severity. In addition to the six studies using only the FAST, one study used the GAF to assess the validity of the Spanish‐language version of the FAST as a new functional scale in patients with BD.…”
Section: Resultsmentioning
confidence: 99%
“…These studies used the FAST to determine correlations between psychosocial functioning and clinical variables (eg, symptoms, number of hospitalizations, number of episodes, duration of illness, trait‐impulsivity, neurologic soft signs), emotion processing, cognitive functioning (eg, verbal learning and memory, visual memory, executive function, perceived cognitive performance), social cognition, sleep disturbances, or demographic variables or to assess overall and domain‐specific functioning in different mood states . The sixth study that used only the FAST to assess psychosocial functioning compared overall functioning in healthy controls and patients with BP‐I or BP‐II and assessed the relationship to cognitive functioning and depression severity. In addition to the six studies using only the FAST, one study used the GAF to assess the validity of the Spanish‐language version of the FAST as a new functional scale in patients with BD.…”
Section: Resultsmentioning
confidence: 99%
“…Cognitive impairment, which is consistently observed in patients with bipolar disorder, is associated with social impairment, worse course of illness, functional disability and diminished global functioning 42 . Dysfunction in several cognitive areas has been noted in acutely ill bipolar patients, with some evidence showing that cognitive dysfunctions may persist in states of remission 43 .…”
Section: Psychosocial Disability and Cognitive Impairmentmentioning
confidence: 99%
“…Meanwhile, loss of interest, low self-esteem and worthlessness could impede patient's problem-solving ability. Kapczinski NS, et al (2016) had demonstrated that the impairment of executive function is worse in patients with severe depression compared to moderate depression. 23 This study did not observe the severity of the depression episode in patients with BD.…”
Section: Discussionmentioning
confidence: 99%
“…Kapczinski NS, et al (2016) had demonstrated that the impairment of executive function is worse in patients with severe depression compared to moderate depression. 23 This study did not observe the severity of the depression episode in patients with BD. Depp CA, et al (2016), stated that there are three pathways of cognitive impairment in bipolar depression; (1) Sustained and recurrent mood symptoms may directly impact neurobiological pathways that diminish cognitive ability; (2) Mood symptoms may indirectly contribute to and exacerbate negative health behaviors that impact cognitive ability; and (3) Disability may reciprocally impact the determinants of cognitive deficits and depressive symptoms.…”
Section: Discussionmentioning
confidence: 99%