Validation of the Addenbrooke’s Cognitive Examination-III in Mild Cognitive Impairment in Arabic Speakers in Egypt

Qassem, Tarik; Khater, Mohamed; Emara, Tamer; Rasheedy, Doha; Tawfik, Heba Mohamed; Mohammedin, Ahmed; Tolba, Mohammad F; Saber, Heba Gamal; El-Gabry, Dina Aly; Aziz, Karim Abdel

doi:10.1159/000510952

Cited by 5 publications

(6 citation statements)

References 23 publications

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“…Addenbrooke’s Cognitive Examination-III (ACE-III) [4] was used to assess cognition. In our study, we used the Arabic version of the ACE-III [20], with a score of <81 indicating MCI in Arabic speakers [15].…”

Section: Methodsmentioning

confidence: 99%

“…To date, there is a shortage of validated cognitive tools in Arabic [14], and few tools have been validated in Arabic speakers with MCI. Previously, the Arabic version of the ACE-III was validated in patients with MCI establishing optimal cut-offs [15], but given that the ACE-III takes 15–20 min to complete, there is a need for quick screening tools in Arabic that can be used to detect MCI.…”

Section: Introductionmentioning

confidence: 99%

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Validation of the Mini-Addenbrooke’s Cognitive Examination in Mild Cognitive Impairment in Arabic Speakers

Qassem

Khater

Emara

et al. 2021

Dement Geriatr Cogn Disord

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Introduction: Mild cognitive impairment (MCI) represents a target for early detection and intervention in dementia, yet there is a shortage of validated screening tools in Arabic to diagnose MCI. The mini-Addenbrooke’s Cognitive Examination (m-ACE) is a brief cognitive battery that is scored out of 30 and can be administered in under 5 min providing a quick screening tool for assessment of cognition. Objective: We aimed to validate the m-ACE in Arabic speakers in Egypt with MCI to provide cut-off scores. Methods: We included 24 patients with MCI and 52 controls and administered the Arabic version of the m-ACE. Results: There was a statistically significant difference (p < 0.0001) on the total m-ACE score between MCI patients (mean 18.54, SD 3.05) and controls (mean 24.54, SD 2.68). There was also a statistically significant difference between MCI patients and controls on the total score and the fluency, visuospatial, and memory recall sub-scores of the m-ACE (p < 0.05). Performance on the m-ACE significantly correlated with both the Mini-Mental State Examination (MMSE) and the Addenbrooke’s Cognitive Examination-III (ACE-III). Using a receiver operator characteristic curve, the optimal cut-off score for MCI on the m-ACE total score was 21 out of 30 (87.5% sensitivity, 84.6% specificity, and 85.5% accuracy). Conclusions: We validated the Arabic m-ACE in Egyptian patients with MCI and provided objective validation of it as a screening tool for MCI, with good sensitivity, specificity, and accuracy that is comparable to other translated versions of the m-ACE in MCI.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Validation of the Mini-Addenbrooke’s Cognitive Examination in Mild Cognitive Impairment in Arabic Speakers

Qassem

Khater

Emara

et al. 2021

Dement Geriatr Cogn Disord

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“…the tasks from English (see Khatib et al, 52 Souissi et al, 64 Qassem et al, [65][66] Soliman et al, 67 and Hassan et al 68 ), while one study 63 used it for task instructions only. To test the accuracy and validity of the translated versions, most articles adopted the forwardbackward translation method.…”

Section: F I G U R Ementioning

confidence: 99%

Cognitive decline assessment in speakers of understudied languages

Hatahet,

Roser,

Seghier

2023

A&D Transl Res & Clin Interv

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Projected trends in population aging have forecasted a massive increase in the number of people with dementia, in particular in sub‐Saharan Africa and the Middle East and North Africa (MENA) region. Cognitive decline is a significant marker for dementia, typically assessed with standardized neuropsychological tools that have been validated in some well‐researched languages such as English. However, with the existing language diversity, current tools cannot cater to speakers of understudied languages, putting these populations at a disadvantage when it comes to access to early and accurate diagnosis of dementia. Here, we shed light on the detrimental impact of this language gap in the context of the MENA region, highlighting inadequate tools and an unacceptable lack of expertise for a MENA population of a half billion people. Our perspective calls for more research to unravel the exact impact of the language gap on the quality of cognitive decline assessment in speakers of understudied languages.Highlights Cognitive decline is a marker for dementia, assessed with neuropsychological tests. There is a lack of culturally valid tests for speakers of understudied languages. For example, suboptimal cognitive tests are used in the Middle East and North Africa region. Linguistic diversity should be considered in the development of cognitive tests.

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“…The ACE-III was developed in 2013, with different versions validated in several countries. 18 19 20 21 22 23 24 25 There is evidence of psychometric property and diagnostic ability to distinguish healthy people from patients with dementia. As in the previous version (ACE-R), ACE-III focuses on five cognitive domains (attention/orientation, memory, verbal fluency, visuospatial ability, and language).…”

Section: Introductionmentioning

confidence: 99%

Addenbrooke's cognitive examination III: diagnostic utility for detecting mild cognitive impairment and dementia in Parkinson's disease

Sousa

Brucki

2023

Arq Neuropsiquiatr

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Background Cognitive deficit in Parkinson disease (PD) is an important cause of functional disability in these patients and early detection, with sensitive instruments, can contribute to longitudinal monitoring. Objective To investigate the diagnostic accuracy, sensitivity, and specificity of the Addenbrooke's Cognitive Examination-III in patients with PD, using the comprehensive neuropsychological battery as reference method. Methods Cross-sectional, observational, case-control study. Setting: rehabilitation service. A total of 150 patients and 60 healthy controls matched for age, sex, and education. For level I assessment, Addenbrooke Cognitive Examination (ACE-III) was used. Level II assessment used a comprehensive neuropsychological battery of standardized tests for this population. All patients remained in on-state during the study. The diagnostic accuracy of the battery was investigated through the receiver operating characteristic (ROC) analysis. Results The clinical group was divided into 3 subgroups: normal cognition in Parkinson's disease (NC-PD-16%), mild cognitive impairment due to Parkinson's disease (MCI-PD-69.33%), and dementia due to Parkinson's disease (D-PD-14.66%). ACE-III optimal cutoff scores for detecting MCI-PD and D-PD were 85/100 (sensitivity 58.65%, specificity 60%) and 81/100 points (sensitivity 77.27%, specificity 78.33%), respectively. Age was inversely associated with the performance of the scores (totals and domains of the ACE-III), while the level of education had a significantly positive correlation in the performance of these scores. Conclusions ACE-III is a useful battery for assessing the cognitive domains and to differentiate individuals with MCI-PD and D-PD from healthy controls. Future research, in a community setting, is necessary to provide discriminatory capacity of ACE-III in the different severities of dementia.

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Validation of the Addenbrooke’s Cognitive Examination-III in Mild Cognitive Impairment in Arabic Speakers in Egypt

Cited by 5 publications

References 23 publications

Validation of the Mini-Addenbrooke’s Cognitive Examination in Mild Cognitive Impairment in Arabic Speakers

Validation of the Mini-Addenbrooke’s Cognitive Examination in Mild Cognitive Impairment in Arabic Speakers

Cognitive decline assessment in speakers of understudied languages

Addenbrooke's cognitive examination III: diagnostic utility for detecting mild cognitive impairment and dementia in Parkinson's disease

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