Validation of a visual‐aided questionnaire for the self‐assessment of hidradenitits suppurativa

Cazzaniga, Simone; Naldi, Luigi; Damiani, Giovanni; Atzori, Laura; Patta, Federico; Guidarelli, G.; Bettoli, Vincenzo

doi:10.1111/jdv.15050

Cited by 18 publications

(21 citation statements)

References 19 publications

(34 reference statements)

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“…The disease affects an estimated 1-4% worldwide and is considered one of the most bur-densome skin conditions [4,5]. Remarkably, diagnosis delay in HS patients remains a global problem [6], so recently a visual-aided questionnaire for self-assessment was proposed [7]. The severe symptoms as well as known complications which tend to limit the range of motion and skin flexibility in lesion areas [2,3] cause considerable physical, social, and emotional distress [8,9].…”

Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

2020

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Background: Psychological comorbidities have been reported in patients with hidradenitis suppurativa (HS), yet only a few studies have investigated the possible association between HS and severe psychiatric disorders. The current study aimed to assess the association between HS and bipolar disorder, a major, chronic, psychiatric disease. Methods: A nationwide, population-based study was performed utilizing data from the Clalit Health Services (CHS) database in Israel. The study included 4,191 HS patients and 20,941 ageand gender-matched controls. A multivariate binary logistic regression, adjusted for demographic and behavioral risk factors, was performed. Results: A higher proportion of bipolar disorders was found among HS patients compared to controls (0.7 vs. 0.1%, respectively). There was an increased proportion of active smokers among HS patients than among controls (53.4 vs. 13.5%, respectively). In the multivariate analysis, adjusting for age, sex, and smoking, HS was found to be independently and positively associated with bipolar disorders (OR 2.12, 95% CI 1.21-3.27, p < 0.01), yet after controlling for body mass this association became nonsignifi-cant. Conclusions: Bipolar disorders are associated with HS. Future studies should explore whether cardiometabolic deficiencies might account for this association. Healthcare providers should consider this potential co-occurrence as it may impede patient compliance and require appropriate screening and treatment. Results also stress the need for a multidisciplinary approach to optimize management of the disease and its associated comorbidities.

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Section: Introductionmentioning

confidence: 99%

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

2020

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“…The prevalence of HS is 1–4% and commonly affects young adult females, with variation likely due to the use of different methods including healthcare records, clinical databases, and self‐questionnaires . More recently, visual‐aided questionnaires have been developed and also used for self‐assessment …”

Section: Introductionmentioning

confidence: 99%

“…3,4 More recently, visual-aided questionnaires have been developed and also used for self-assessment. 5 Hidradenitis suppurativa is associated with a number of disorders, including those of endocrine, cardiovascular, and autoimmune etiology. Although a quantitative score for the comorbidity burden of HS is still not established, the Charlson Comorbidity Index 6 and newly proposed Autoinflammatory Disease Damage Index (ADDI) have been used.…”

Section: Introductionmentioning

confidence: 99%

Hidradenitis suppurativa and metabolic syndrome – systematic review and adjusted meta‐analysis

2019

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Background Hidradenitis suppurativa (HS) is a debilitating and distressing chronic systemic inflammatory skin disease. There have been several prior observational studies which reported a possibility link between HS and metabolic syndrome, however the current evidence is not definitive. It is unclear in HS whether this possible relationship is independent or driven by underlying risk factors and comorbidities. Objective To determine whether HS is independently associated with metabolic syndrome via adjusted meta‐analysis of case‐control studies. Methods A systematic review and meta‐analysis was performed according to PRISMA guidelines. Electronic searches were performed using six electronic databases (Ovid Medline, PubMed, CCTR, CDSR, ACP Journal Club, and DARE) from their inception until September 2018. Data were extracted and analyzed according to predefined clinical endpoints. Results We identified six case‐control studies included for meta‐analysis. Based on unadjusted analysis, we found a significant association between adult cases of HS and metabolic syndrome (OR 1.95, 95% CI 1.31–2.89, P = 0.001). Adjusted meta‐analysis, after adjustment for age, sex, other cardiovascular risk factors, and comorbidities, found a significant association (OR 2.19, 95% CI 1.70–2.81, I2 = 32%, P < 0.00001). Limitations Studies reviewed were observational by design which are susceptible to bias, and there was lack of randomization. The quality of the current systematic review is also limited by the quality of available evidence which was predominantly observational in nature. Conclusions This pooled analysis of existing case‐control studies supports an association between HS and metabolic syndrome. Clinicians treating patients with HS should be aware of this potential association.

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“…Psychiatric comorbidity of HS patients is also often overlooked, and concurrent schizophrenia may involve a general undertreatment of medical conditions typically affecting this population . As medical management is shifting towards the development of assessments aimed at providing early detection and intervention, the results of the current study emphasize the importance of integrating a broader assessment to detect and account for both dermatological and psychological factors that might affect medical care. This assessment is especially crucial when considering the higher prevalence of attempted suicide in both schizophrenia and HS patients, as well as the importance of early treatment in both HS and schizophrenia, which might dramatically affect treatment options and outcomes.…”

Section: Discussionmentioning

confidence: 96%

Hidradenitis suppurativa and schizophrenia: a nationwide cohort study

Bitan

Berzin

Cohen

2019

Acad Dermatol Venereol

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Background Hidradenitis suppurativa (HS) is a chronic, debilitating, dermatological disease that causes substantial psychosocial impediments with increased suicidal risk. Yet data on psychiatric comorbidity in HS have not been sufficiently elucidated in population‐based studies. The current study sought to investigate the association between HS and schizophrenia, a major psychiatric disease, in a nationwide population‐based study in Israel. Methods Data mining was performed on the database of Clalit Health Services (CHS), the largest managed healthcare company in Israel. Patients diagnosed with HS (n = 4191) were examined and compared to age‐ and sex‐matched controls (n = 20 941). The association between HS and schizophrenia was assessed via multivariate binary logistic regression, adjusting for demographic factors and smoking status. Results The analysis revealed a tenfold increase in the prevalence of schizophrenia in HS patients compared to controls (1.4% and 0.4%, respectively, P < 0.001). In multivariate analysis, HS was found to be associated with schizophrenia (OR 1.44, 95% CI 1.01–2.07, P < 0.05). Conclusions Hidradenitis suppurativa is associated with schizophrenia. Screening for severe mental illness during the assessment of patients with HS is of great importance, as comorbid psychiatric disorders may affect treatment outcomes.

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Validation of a visual‐aided questionnaire for the self‐assessment of hidradenitits suppurativa

Abstract: The questionnaire could be a useful tool for HS screening in the general population. Further studies are needed to confirm its performance in a real-world setting.

Cited by 18 publications

References 19 publications

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

Hidradenitis Suppurativa and Bipolar Disorders: A Population-Based Study

Hidradenitis suppurativa and metabolic syndrome – systematic review and adjusted meta‐analysis

Hidradenitis suppurativa and schizophrenia: a nationwide cohort study

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