Hidradenitis suppurativa and metabolic syndrome – systematic review and adjusted meta‐analysis

Phan, Kevin; Charlton, Olivia; Smith, Saxon D

doi:10.1111/ijd.14500

Cited by 27 publications

(28 citation statements)

References 38 publications

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“…A significant association was found between HS and visfatin, insulin and C-reactive protein (CRP) levels, with each unit increase in visfatin and insulin increasing the risk of HS by 1.56- and 1.09-times, respectively. Finally, a recent meta-analysis of case-control studies addressing the relationship between HS and metabolic syndrome computed a crude odds-ratio (OR) of 1.95 (95% CI 1.31–2.89) and, after correcting for age, sex, other cardiovascular risk factors, and co-morbidities, an adjusted OR of 2.19 (95% CI 1.70–2.81) was obtained [33].…”

Section: Discussionmentioning

confidence: 99%

The Safety and Impact of a Model of Intermittent, Time-Restricted Circadian Fasting (“Ramadan Fasting”) on Hidradenitis Suppurativa: Insights from a Multicenter, Observational, Cross-Over, Pilot, Exploratory Study

et al. 2019

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Hidradenitis suppurativa (HS) is a chronic-relapsing and debilitating disease, which affects the components of the folliculopilosebaceous unit and severely impacts on the perceived health-related quality of life. Among the possible treatments, dietary interventions, such as fasting, have been described to positively impact on HS. However, nothing is known about the effects of circadian, intermittent fasting, such as the Ramadan fasting. A sample of 55 HS patients (24 males (43.6%) and 31 females (56.4%), mean age 39.65 ± 8.39 years, average disease duration 14.31 ± 7.03 years) was recruited in the present study. The “Severity of International Hidradenitis Suppurativa Severity Score System” (IHS4) decreased significantly from 11.00 ± 5.88 (before Ramadan) to 10.15 ± 6.45 (after Ramadan), with a mean difference of −0.85 ± 0.83 (p < 0.0001). At the univariate analyses, the improvement was associated with HS phenotype (with a prominent improvement among those with ectopic type), treatment (with the improvement being higher in patients receiving topical and systemic antibiotics compared to those treated with biologics), the “Autoinflammatory Disease Damage Index” (ADDI), and Hurley scores. At the multivariate regression analysis, only the Hurley score (regression coefficient = 0.70, p = 0.0003) was found to be an independent predictor of change in the IHS4 score after fasting. The improvement in the IHS4 score was not, however, associated with weight loss. In conclusion, the Ramadan fasting proved to be safe and effective in HS patients. Considering the small sample size and the exploratory nature of the present investigation, further studies in the field are warranted, especially longitudinal, prospective and randomized ones.

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Section: Discussionmentioning

confidence: 99%

The Safety and Impact of a Model of Intermittent, Time-Restricted Circadian Fasting (“Ramadan Fasting”) on Hidradenitis Suppurativa: Insights from a Multicenter, Observational, Cross-Over, Pilot, Exploratory Study

et al. 2019

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“…There is clearly an urgent need to definitely characterise both the cutaneous and gastrointestinal microbiome in HS, not only given the association between HS and inflammatory bowel disease [72] but also given the role of antimicrobial therapy in the management of HS, which itself can dramatically and fundamentally alter the composition of the gastrointestinal bacterial flora. The extent to which these changes may contribute to the HS pathophysiology, either promoting disease progression or even serving a protective role, needs to be urgently clarified to optimise treatment selection.…”

Section: Environmental Factorsmentioning

confidence: 99%

The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel

Langan

Recke

Bokor-Billmann

et al. 2020

IJMS

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The development of next generation sequencing, coupled with advances in bio-informatics, has provided new insights into the role of the cutaneous microbiome in the pathophysiology of a range of inflammatory skin diseases. In fact, it has even been suggested that the identification of specific skin microbial signatures may not only be useful in terms of diagnosis of skin diseases but they may also ultimately help inform personalised treatment strategies. To date, research investigating the role of microbiota in the development of inflammatory skin diseases has largely focused on atopic eczema and psoriasis vulgaris. The role of the microbiome in Hidradenits suppurativa (HS)-also known as acne inversa-a chronic auto-inflammatory skin disease associated with significant morbidity, has received comparatively little attention. This is despite the fact that antimicrobial therapy plays a central role in the treatment of HS. After briefly outlining the clinical features of HS and current treatment strategies, we move on to review the evidence of microbial dysbiosis in HS pathophysiology. We conclude by outlining the potential for metagenomic studies to deepen our understanding of HS biology but more importantly to identify novel and much needed treatment strategies.scoring and the HS severity index. Whilst the precise incidence and prevalence of HS is unclear [8], due partly to the diagnostic difficulty associated with HS and the use of both registry data and self-report questionnaires [9]. Garg et al. reported a prevalence of 0.1% in a US-based population analysis, leading the authors to conclude that HS is an uncommon but not rare disease, with over-representation in young, female and African American patients [10]. The current multi-modal treatment approach includes the use of intralesional steroids, surgical and laser therapy, topical and systemic medical antimicrobial therapy and biologic treatments [11].Sartorius scoring and the HS severity index. Whilst the precise incidence and prevalence of HS is unclear [8], due partly to the diagnostic difficulty associated with HS and the use of both registry data and self-report questionnaires [9]. Garg et al. reported a prevalence of 0.1% in a US-based population analysis, leading the authors to conclude that HS is an uncommon but not rare disease, with over-representation in young, female and African American patients [10]. The current multi-modal treatment approach includes the use of intralesional steroids, surgical and laser therapy, topical and systemic medical antimicrobial therapy and biologic treatments [11].

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“…Obezite, HS'de daha sık görülür büyük olasılıkla intertriginöz ciltte artmış mekanik strese bağlı hastalığı kötüleştirebilir, ancak vücut kitle indeksi ile HS şiddeti arasındaki korelasyon tartışmalıdır. Artan kanıtlar, sağlıklı kontrollere kıyasla, HS hastalarında artmış sistemik inflamatuar yükün sonucu, insülin direnci, dislipidemi, endotel disfonksiyonu ve ateroskleroz gelişi-mine katkıda bulunan faktörlerin daha yüksek prevalans oranlarını göstermektedir (14). Literatürde sık görülen metabolik sendrom ile HS birlikteliğinin aksine, çalışmamızda, gut ve SAPHO sendromu tanısı ile takipli olan iki hasta dışında hiperlipidemi, obesite ve hiperglisemi tesbit edilmedi.…”

Section: Bulgularunclassified

Romatoloji̇k Hastaliklarda Hi̇dradeni̇ti̇s Süpürati̇va’nin Önemi̇

Tezcan¹,

Limon²,

Gülcemal³

et al. 2020

J Istanb Fac Med

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Amaç: Hidradenitis suppurativa (HS), özellikle puberte sonrası, kadınlarda daha sık görülen apokrin glandların tekrarlayıcı kronik inflamatuar bir hastalığıdır. Primer tutulum bölgeleri aksiller, inguinal, perianal, perineal bölgeler olan hastalık, ağrılı bir nodülden, abse, sinüs oluşumu ve hipertrofik skarlara kadar değişen bir semptom kompleksinden oluşur. Başta obezite ve metabolik sendrom olmak üzere, spondiloartrit, otoinflamatuar hastalıklar ve bazı otoimmün hastalıklar HS hastalarında daha sık görülür. Bu çalışmamızda romatoloji kliniğimizde takipli olan ve HS tanısı almış hastalarda etyolojik, demografik ve klinik özelliklerin belirlenmesi amaçlanmıştır.

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Hidradenitis suppurativa and metabolic syndrome – systematic review and adjusted meta‐analysis

Cited by 27 publications

References 38 publications

The Safety and Impact of a Model of Intermittent, Time-Restricted Circadian Fasting (“Ramadan Fasting”) on Hidradenitis Suppurativa: Insights from a Multicenter, Observational, Cross-Over, Pilot, Exploratory Study

The Safety and Impact of a Model of Intermittent, Time-Restricted Circadian Fasting (“Ramadan Fasting”) on Hidradenitis Suppurativa: Insights from a Multicenter, Observational, Cross-Over, Pilot, Exploratory Study

The Role of the Cutaneous Microbiome in Hidradenitis Suppurativa—Light at the End of the Microbiological Tunnel

Romatoloji̇k Hastaliklarda Hi̇dradeni̇ti̇s Süpürati̇va’nin Önemi̇

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