Valerenic acid potentiates and inhibits GABAA receptors: Molecular mechanism and subunit specificity

Khom, Sophia; Baburin, Igor; Timin, E. N.; Hohaus, Annette; Trauner, Gabriele; Kopp, Brigitte; Hering, Steffen

doi:10.1016/j.neuropharm.2007.04.018

Cited by 143 publications

(156 citation statements)

References 37 publications

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“…The compounds accumulated mainly in the roots and rhizomes of valerian include valepotriates (iridoids), the components of the volatile oil, sesquiterpenes as valerenic acid (VA) and its derivatives, monoterpenes as well as a number of other constituents [4]. Although the identity of the active components responsible for the beneficial health effects in valerian is still uncertain, in recent findings the main pharmacological effects have been attributed to valerenic acid and its derivatives including acetoxyvalerenic acid and hydroxyvalerenic acid [5,6]. Also, VA along with its derivatives is often used to indicate medicinal quality [4,7].…”

Section: Introductionmentioning

confidence: 99%

Enhanced production of valerenic acid in hairy root culture of Valeriana officinalis by elicitation

Torkamani

Jafari²,

Abbaspour

et al. 2014

Open Life Sciences

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Valerenic acid (VA) is a pharmacologically-active sesquiterpene found in valerian (Valeriana officinalis L., Valerianaceae) roots and rhizomes. The plant produces only small amounts of this metabolite naturally. So, induction of hairy roots as well as elicitation can be useful to increase its commercial production. In this study, Wild-type strain ‘A13’ of Agrobacterium rhizogenes was used to induce hairy roots in valerian. The influence of three different elicitors including Fusarium graminearum extract (FE), methyl jasmonate (MJ) and salicylic acid (SA) on VA production in the selected hairy root line ‘LeVa-C4’ was also investigated. The 23-day-old cultures were treated with different concentrations of the elicitors at exposure time of 3 and 7 days. FE (1%) and MJ (100 µM L−1) highly promoted VA production at 7 days after elicitation, to a level of 12.31- and 6-fold higher than that of non-elicited controls, respectively, and FE did not exert any negative effects on biomass yield of hairy root. SA did not significantly increase the production of VA. This is the first time study to assess the elicitation of hairy root cultures to promote VA biosynthesis in valerian and the resulting experiments demonstrated that F. graminearum extract and MJ were indeed a potent inducer of VA biosynthesis.

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Section: Introductionmentioning

confidence: 99%

Enhanced production of valerenic acid in hairy root culture of Valeriana officinalis by elicitation

Torkamani

Jafari²,

Abbaspour

et al. 2014

Open Life Sciences

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“…Компоненты валерианы также являются аллосте-рическими модуляторами субъединице-специфических ГАМК-А-каналов [25] и аденозиновых А1-рецепторов [26]. В экспериментальных исследованиях был уста-новлен выраженный анксиолитический эффект [27], обусловленный связыванием валереновой кислоты и ее производных со специфической бета-3-субъединицей ГАМК-А-рецептора [28].…”

Section: валериана (Valeriana Officinalis)unclassified

Лечение Тревожно-Депрессивных Расстройств В Соматической Практике: Назначение Комбинации Экстрактов Зверобоя И Валерианы

Romanenko¹,

Romanenko²,

Романенко³

2022

INJ

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“…They were proposed for valerian mainly with drugs influencing vigilance such as codeine, citalopram, and benzodiazepines. A presumable interaction with benzodiazepines, which are positive allosteric modulators on GABA-receptors, is based on in Evidence-Based Complementary and Alternative Medicine 5 vitro data suggesting GABAergic mechanisms of action of valerian extracts [49,50]. These studies however are inconclusive and require independent replication.…”

Section: Pharmacodynamic Interactionsmentioning

confidence: 99%

Valerian: No evidence for Clinically Relevant interactions

Kelber¹,

Nieber²,

Kraft³

2012

Planta Med

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In recent popular publications as well as in widely used information websites directed to cancer patients, valerian is claimed to have a potential of adverse interactions with anticancer drugs. This questions its use as a safe replacement for, for example, benzodiazepines. A review on the interaction potential of preparations from valerian root (Valeriana officinalis L. root) was therefore conducted. A data base search and search in a clinical drug interaction data base were conducted. Thereafter, a systematic assessment of publications was performed. Seven in vitro studies on six CYP 450 isoenzymes, on p-glycoprotein, and on two UGT isoenzymes were identified. However, the methodological assessment of these studies did not support their suitability for the prediction of clinically relevant interactions. In addition, clinical studies on various valerian preparations did not reveal any relevant interaction potential concerning CYP 1A2, 2D6, 2E1, and 3A4. Available animal and human pharmacodynamic studies did not verify any interaction potential. The interaction potential of valerian preparations therefore seems to be low and thereby without clinical relevance. We conclude that there is no specific evidence questioning their safety, also in cancer patients.

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Valerenic acid potentiates and inhibits GABAA receptors: Molecular mechanism and subunit specificity

Cited by 143 publications

References 37 publications

Enhanced production of valerenic acid in hairy root culture of Valeriana officinalis by elicitation

Enhanced production of valerenic acid in hairy root culture of Valeriana officinalis by elicitation

Лечение Тревожно-Депрессивных Расстройств В Соматической Практике: Назначение Комбинации Экстрактов Зверобоя И Валерианы

Valerian: No evidence for Clinically Relevant interactions

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