Vaginal progesterone in risk reduction of preterm birth in women with short cervix in the midtrimester of pregnancy

Khandelwal, Meena

doi:10.2147/ijwh.s28944

Cited by 24 publications

(29 citation statements)

References 72 publications

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“…13 However, despite extensive efforts, the management of preterm labor, continue to be a major challenge for clinicians.…”

Section: Discussionmentioning

confidence: 99%

“…13 Several indicators can help to predict preterm labor 3 but most studies have shown that the most powerful predictors of Progesterone therapy for the prevention of preterm labor in women with single risk-factor: a systematic review and meta-analysis preterm labor are the history of previous preterm labor and short cervix length. 3,6,10,12,13, 16 Various studies have shown that the risk of preterm labor in women with a previous history is at least 2.5 times more than that of women without previous preterm labor and this rate increases as the number of previous preterm labor increases.…”

Section: -17mentioning

confidence: 99%

“…13 In order to prevent the occurrence of preterm labor, after identification of at risk women, effective preventive interventions should be designed and applied. So far, the treatment with a variety of different drugs has been the first method of treatment.…”

mentioning

confidence: 99%

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Progesterone Therapy for the Prevention of Preterm Labor in Women with Single Risk-factor: A Systematic Review and Meta-analysis

Ara¹,

Bahrami

Bahrami³

et al. 2016

Bali Med J.

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Background: Preterm labor is a common complication of pregnancy which has become a main health concern around the world due to its negative consequences. Objective: To investigate the efficacy of progesterone therapy in the prevention of preterm labor in women with single risk factor. Search strategy: A PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Science Direct, Scopus, OVID, EMBASE, SID, Magiran and Google Scholar search (date last searched April 2016) without any time, language and location restriction was done. Inclusion criteria: All randomized clinical trials of singleton pregnancies with single risk factor (prior preterm labor without short cervical length or short cervical length without prior preterm labor) which were randomized to progesterone and control groups were included in our meta-analysis. Primary outcome: Our primary outcome was gestational age at delivery. Results: 13 studies (1259 subjects and 2653 control women) were included in the meta-analysis. Using random effect model showed that mean gestational age at delivery of progesterone group is 0.74 (0.41-1.06) month longer than that of control group with CI=95% which is significant statically. Conclusions: Progesterone therapy is an effective intervention for the prevention of preterm labor in women with single risk factor.

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“…13 However, despite extensive efforts, the management of preterm labor, continue to be a major challenge for clinicians.…”

Section: Discussionmentioning

confidence: 99%

Section: -17mentioning

confidence: 99%

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Progesterone Therapy for the Prevention of Preterm Labor in Women with Single Risk-factor: A Systematic Review and Meta-analysis

Ara¹,

Bahrami

Bahrami³

et al. 2016

Bali Med J.

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“…Studies show that the risk of death in preterm infants is more than 40 times higher than that in other babies (5). Although advances in recent decades has increased the survival chance of premature infants, the survived prematurely born babies is more likely to experience long-term health problems during their lives (7)(8)(9)(10)(11)(12)(13)(14). Also, the financial burden of preterm birth is another important negative consequence.…”

Section: Introductionmentioning

confidence: 99%

“…Thus, the search for effective approaches for the prevention and control of preterm delivery is one of the major research topics among clinicians. The first step in the prevention of preterm birth is the correct identification of women who are at risk of preterm delivery (10). Several indicators can help to predict preterm delivery, (1) but studies have shown that the most powerful predictors of preterm delivery are the history of previous preterm delivery and the short cervix length during pregnancy (9,10,13).…”

Section: Introductionmentioning

confidence: 99%

The Efficacy of Progesterone Therapy for the Prevention of Preterm Labor in Women with Mixed Risk-factors: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Ara¹,

Bahrami²,

Bahrami³

et al. 2018

Erciyes Med J

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Background: Preterm birth is a worldwide concern with widespread negative consequences. Therefore, prevention of preterm birth has become a top priority of health managers and clinicians in recent decades.Objective: To evaluate the efficacy of progesterone therapy in the prevention of preterm labor in women with mixed risk factors.Search strategy: An extensive search of electronic databases was done (date last searched April 2016). No restrictions of language, time, or geographic location were applied.Inclusion criteria: All randomized clinical trials of singleton pregnancies with multiple risk factors (including prior preterm birth and short cervical length) that were randomized to treatment with progesterone (intervention group) and placebo or no treatment (control group) were included in meta-analysis.Primary outcome: Our primary outcome was gestational age at delivery.Results: Three Randomized Clinical Trials (521 subjects and 37,823 control women) were included. A random effect model showed that mean gestational age at delivery of progesterone group is 0.18 (-0.41-0.77) month longer than that of control group with with 95% confidence interval but this difference is not statically significant. Conclusions:Progesterone therapy does not have sufficient efficacy in the prevention of preterm labor in women with multiple risk factors. However, further investigation is required to unequivocally establish this result.

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Effectiveness of high‐dose transvaginal progesterone supplementation for women who are undergoing a frozen‐thawed embryo transfer

Enatsu

Kishi

et al. 2018

Reprod Medicine & Biology

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PurposeTo evaluate the effectiveness of high‐dose progesterone supplementation for women who are undergoing a frozen‐thawed embryo transfer (FET).MethodsAmong the 2010 FET cycles that were included in the present study, 1188 were 1200 mg/d of vaginal progesterone, while 822 were 900 mg/d. The dose of progesterone that was used was decided by the treatment period and additional progesterone supplementation was used when the serum progesterone levels were <9 ng/mL on luteal day 5.ResultsThe clinical pregnancy rate was higher in the 1200 mg group than in the 900 mg group. The mean serum progesterone level on luteal day 5 in the 1200 mg and 900 mg groups was 12.6 ng/mL and 13.4 ng/mL, respectively. The rate of additional progesterone supplementation was higher in the 1200 mg group. A logistic regression analysis identified a younger age (≤37 years) and the use of 1200 mg progesterone as independent predictive factors for the clinical pregnancy outcome. The analysis of the infant outcomes revealed no significant difference in the distribution of birth ages and weights.ConclusionHigh‐dose transvaginal progesterone of 1200 mg/d as luteal support contributed to good pregnancy outcomes.

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Vaginal progesterone in risk reduction of preterm birth in women with short cervix in the midtrimester of pregnancy

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Cited by 24 publications

References 72 publications

Progesterone Therapy for the Prevention of Preterm Labor in Women with Single Risk-factor: A Systematic Review and Meta-analysis

Progesterone Therapy for the Prevention of Preterm Labor in Women with Single Risk-factor: A Systematic Review and Meta-analysis

The Efficacy of Progesterone Therapy for the Prevention of Preterm Labor in Women with Mixed Risk-factors: A Systematic Review and Meta-analysis of Randomized Clinical Trials

Effectiveness of high‐dose transvaginal progesterone supplementation for women who are undergoing a frozen‐thawed embryo transfer

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