Progesterone Therapy for the Prevention of Preterm Labor in Women with Single Risk-factor: A Systematic Review and Meta-analysis

Abstract

Background: Preterm labor is a common complication of pregnancy which has become a main health concern around the world due to its negative consequences. Objective: To investigate the efficacy of progesterone therapy in the prevention of preterm labor in women with single risk factor. Search strategy: A PubMed, Cochrane Central Register of Controlled Trials, ClinicalTrials.gov, Science Direct, Scopus, OVID, EMBASE, SID, Magiran and Google Scholar search (date last searched April 2016) without any time, language and location restriction was done. Inclusion criteria: All randomized clinical trials of singleton pregnancies with single risk factor (prior preterm labor without short cervical length or short cervical length without prior preterm labor) which were randomized to progesterone and control groups were included in our meta-analysis. Primary outcome: Our primary outcome was gestational age at delivery. Results: 13 studies (1259 subjects and 2653 control women) were included in the meta-analysis. Using random effect model showed that mean gestational age at delivery of progesterone group is 0.74 (0.41-1.06) month longer than that of control group with CI=95% which is significant statically. Conclusions: Progesterone therapy is an effective intervention for the prevention of preterm labor in women with single risk factor.

Female Genital Tuberculosis Among Infertile Women and Its Contributions to Primary and Secondary Infertility

“…20 Worldwide, the prevalence was 24.2% in the first published metaanalysis and systematic review in 2016. 21 However, the current study finding is 20% which is slightly decreased. This outcome is due to the relative progress in the availability of more sensitive TB diagnosis methods such as GeneXpert and PCR in developing countries.…”

Comparing Prophylactic Vaginal Progesterone & Cervical Cerclage In Preventing Preterm Birth: A Systematic Review

“…Preterm birth is a multifactorial condition that could be triggered by a variety of risk factors [1]. The key preventive measure for PTB lies in the correct identification of risk factor that could increase the incidence of preterm birth in a pregnancy [1].…”

“…Preterm birth is a multifactorial condition that could be triggered by a variety of risk factors [1]. The key preventive measure for PTB lies in the correct identification of risk factor that could increase the incidence of preterm birth in a pregnancy [1]. Preterm birth is more likely when there is vaginal bleeding in the second trimester, according to Salim et al [9] or past history of cervical trauma/ preterm birth [8].…”

“…Preterm birth (PTB) is the delivery of a child after the 20th week but before the completion of 37th week of pregnancy [1]. It is a prominent cause of prenatal death and morbidity across the world (about 1.1 million annually), and long-term neurodevelopmental disabilities and accounts for about 11% of pregnancies [2].…”

Uterocervical Angle Anterior, Posterior, and Cervical Length Ultrasound as a Predictors for Successful Delay in Labor of Pregnant Women with Threatened Preterm Birth (PTB)

“…In a more recent study, the width of the anterior and posterior uterocervical angles (UCA), where this angle is formed between the endocervical canal and the anterior and posterior walls of the uterus, was a predictor of preterm labor. 12,13 The aim of this study is to assess the ability of uterocervical angle anterior, posterior, cervical length, and combination whether these parameters can be used as predictors of successful delay in labor in patients with threatened PTB. Threatened Preterm Birth (PTB) Pharmacognosy Journal, Vol 15, Issue 1, Jan-Feb, 2023 delivery room at dr. Soetomo Hospital between May until September 2022 with that met the inclusion and exclusion criteria.…”