Vaginal lichen planus: preservation of sexual function in severe disease

Machin, Sarah Elizabeth; McConnell, Dynes T.; Adams, John

doi:10.1136/bcr.08.2009.2208

Cited by 14 publications

(10 citation statements)

References 12 publications

(10 reference statements)

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“…In this study, urogenital abnormalities associated with LP, were represented by bacterial/fungal infections, urethritis, pyelonephritis, cystitis and problems in urine evacuation. Some studies have shown the association between vaginal LP and squamous cell carcinoma, human papilloma virus (HPV) infection or dysuria [6,7].…”

Section: Leukocytesmentioning

confidence: 99%

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Reflectometric Analysis for Identification of Various Pathological Conditions Associated with Lichen Planus

Georgescu¹,

Ene²,

Nicolae³

et al. 2017

Rev. Chim.

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Reflectometric technique for analyzing urine strips represents a simple, fast and inexpensive method, with no risk and discomfort for the patient. In the present paper, the authors conducted a retrospective study on the possible association between lichen planus (LP) and a number of pathological conditions that produce changes of urine metabolites. A retrospective study was made on 77 patients with LP (49 cases of cutaneous LP - CLP, 28 cases of oral LP - OLP) who were diagnosed and treated in the dermatology department of Victor Babes Hospital for Infectious and Tropical Diseases. The quantification of certain urine metabolites in the spontaneous urine through reflectometric technique may reveal liver diseases (urobilinogen, bilirubin), kidney diseases (erythrocytes, proteins, albumin, creatinine, albumin/creatinine ratio, urine specific gravity, pH), metabolic disorders (glucose, ketones, pH, ascorbic acid) and urinary diseases (leucocyturia, nitrites, proteins, erythrocytes). The evaluation of the patients included clinical examination and laboratory and imaging tests. Among the investigated patients with LP we found: 16 cases of hepatic dysfunction (20.8%), 7 cases of renal dysfunction (9.1%), 11 cases of metabolic disorders (14.3%) and 14 cases of urinary tract infections (18.2%). No differences were found between patients with cutaneous and oral LP. The linear regression analysis revealed: positive association between concentrations of urobilinogen and bilirubin (r = 0.174, p = 0.044), negative association between albumin and creatinine (r = -0.316, p = 0.007), positive association between glucose and ketones (r = 0.266, p = 0.098) and positive association between leucocyturia and urine nitrite levels (r = 0.202, p = 0.050). Based on clinical and laboratory data, 85.7% of results obtained from urine biochemistry were confirmed. This analysis did not find any difference between patients with cutaneous and oral LP. By determining a full panel of urine metabolites through reflectometric analysis we were able to identify the main pathological changes in patients with LP.

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Section: Leukocytesmentioning

confidence: 99%

“…Lichen planus (LP) is a complex immunologically mediated disease, which affects the skin and mucous membranes, being an important concern for medical research [1][2][3][4][5][6][7]. The global prevalence of LP varies between 0.22 and 5% [8].…”

mentioning

confidence: 99%

Reflectometric Analysis for Identification of Various Pathological Conditions Associated with Lichen Planus

Georgescu¹,

Ene²,

Nicolae³

et al. 2017

Rev. Chim.

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“…Hypertrophic variant is the rarest among vulval LP and when present usually mimics squamous cell carcinoma. 4 The main differential diagnosis to be considered in this setting is verrucous carcinoma of the vulva, a variant of squamous cell carcinoma. They are characterised by asymptomatic, slow-growing exophytic lesions on the vulva, which may be locally destructive.…”

Section: Discussionmentioning

confidence: 99%

Lichen planus hypertrophicus of the vulva – a rare entity

Job

Kaimal

2017

Int J STD AIDS

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Vulvovaginal lichen planus is a type of chronic inflammatory dermatosis of the vulva, usually seen as a part of widespread lichen planus. The common clinical types of vulval lichen planus include papulosquamous, erosive and pigmented types. Hypertrophic lichen planus of the vulva is a rare entity. We report a case of hypertrophic lichen planus of the vulva which clinically simulated genital warts.

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“…The disease occurs mainly in the oral mucosa, but it can also develop in the female vagina (Machin et al 2010 ), where it is often missed or misdiagnosed. The authors reported that the vaginal manifestation can progress rapidly, increasing morbidity and affecting sexual function; if left untreated, it can produce adhesions that completely occlude the vagina, requiring surgery.…”

Section: On the Diseasementioning

confidence: 99%

Oral lichen planus: a microbiologist point of view

2021

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Oral lichen planus (OLP) is a chronic disease of uncertain etiology, although it is generally considered as an immune-mediated disease that affects the mucous membranes and even the skin and nails. Over the years, this disease was attributed to a variety of causes, including different types of microorganisms. This review analyzes the present state of the art of the disease, from a microbiological point of view, while considering whether or not the possibility of a microbial origin for the disease can be supported. From the evidence presented here, OLP should be considered an immunological disease, as it was initially proposed, as opposed to an illness of microbiological origin. The different microorganisms so far described as putative disease-causing agents do not fulfill Koch’s postulates; they are, actually, not the cause, but a result of the disease that provides the right circumstances for microbial colonization. This means that, at this stage, and unless new data becomes available, no microorganism can be envisaged as the causative agent of lichen planus.

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Vaginal lichen planus: preservation of sexual function in severe disease

Cited by 14 publications

References 12 publications

Reflectometric Analysis for Identification of Various Pathological Conditions Associated with Lichen Planus

Reflectometric Analysis for Identification of Various Pathological Conditions Associated with Lichen Planus

Lichen planus hypertrophicus of the vulva – a rare entity

Oral lichen planus: a microbiologist point of view

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