Vaccine targets against<i>Moraxella catarrhalis</i>

Ren, Dabin; Pichichero, Michael E.

doi:10.1517/14728222.2015.1081686

Cited by 32 publications

(24 citation statements)

References 115 publications

(153 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vaccines targeting the other three main bacterial pathogens in pediatric bronchiectasis, M. catarrhalis, P. aeruginosa, and S. aureus are not yet commercially available; their development has been reviewed by others (196)(197)(198).…”

Section: Impact Of Vaccinesmentioning

confidence: 99%

Bronchiectasis in Children: Current Concepts in Immunology and Microbiology

2017

View full text Add to dashboard Cite

Bronchiectasis is a complex chronic respiratory condition traditionally characterized by chronic infection, airway inflammation, and progressive decline in lung function. Early diagnosis and intensive treatment protocols can stabilize or even improve the clinical prognosis of children with bronchiectasis. However, understanding the host immunologic mechanisms that contribute to recurrent infection and prolonged inflammation has been identified as an important area of research that would contribute substantially to effective prevention strategies for children at risk of bronchiectasis. This review will focus on the current understanding of the role of the host immune response and important pathogens in the pathogenesis of bronchiectasis (not associated with cystic fibrosis) in children.

show abstract

Section: Impact Of Vaccinesmentioning

confidence: 99%

Bronchiectasis in Children: Current Concepts in Immunology and Microbiology

2017

View full text Add to dashboard Cite

show abstract

“…Moraxella catarrhalis expresses two different TAAs on its outer membrane, the ubiquitous surface protein A1 (UspA1) and the ubiquitous surface protein A2 (UspA2) [18,161].…”

Section: Moraxella Catarrhalis Taasmentioning

confidence: 99%

“…The role of M. catarrhalis as causative agent of COPD has long been underestimated, however, is a frequent pathogen in the acute exacerbation phase of the disease [141,165]. Other related illnesses are meningitis, sinusitis and pneumonia [18,162]. Diseases caused by M. catarrhalis are a serious burden for health systems worldwide [166,167].…”

Section: Moraxella Catarrhalis Taasmentioning

confidence: 99%

“…Diseases caused by M. catarrhalis are a serious burden for health systems worldwide [166,167]. Moreover, M. catarrhalis produces ß-lactamases and is thus resistant against various important antibiotics [18]. Alternative therapies, such as M. catarrhalis vaccines, are, therefore, highly desirable [168].…”

Section: Moraxella Catarrhalis Taasmentioning

confidence: 99%

“…1). In this review, we focus on the immunogenicity and vaccine candidacy of trimeric autotransporter adhesins (TAA) as one particular group of outer membrane proteins (OMPs) of Gram-negative bacteria [12][13][14][15][16][17] Principally, the most important conditions necessary to be an effective vaccine component are (i) the in vivo expression of surface epitopes, (ii) a high strain coverage, and (iii) immunogenicity and induction of a protective immune response in the host [18,19]. In general, bacterial membrane proteins such as TAAs perform numerous important functions in pathogenesis, of which the first interaction with the extracellular environment in the mammalian host is of crucial importance.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Thibau

Dichter

Vaca

et al. 2019

Med Microbiol Immunol

View full text Add to dashboard Cite

The current problem of increasing antibiotic resistance and the resurgence of numerous infections indicate the need for novel vaccination strategies more than ever. In vaccine development, the search for and the selection of adequate vaccine antigens is the first important step. In recent years, bacterial outer membrane proteins have become of major interest, as they are the main proteins interacting with the extracellular environment. Trimeric autotransporter adhesins (TAAs) are important virulence factors in many Gram-negative bacteria, are localised on the bacterial surface, and mediate the first adherence to host cells in the course of infection. One example is the Neisseria adhesin A (NadA), which is currently used as a subunit in a licensed vaccine against Neisseria meningitidis. Other TAAs that seem promising vaccine candidates are the Acinetobacter trimeric autotransporter (Ata), the Haemophilus influenzae adhesin (Hia), and TAAs of the genus Bartonella. Here, we review the suitability of various TAAs as vaccine candidates.

show abstract

Moraxella

Fernández‐Garayzábal¹,

Miguela‐Villoldo²,

Vela³

2022

Bergey's Manual of Systematics of Archaea and Bacteria

View full text Add to dashboard Cite

Mo.ra.xel'la. N.L. dim. fem. n. Moraxella , named after V. Morax, a Swiss ophthalmologist who pioneered the recognition of the type species. Proteobacteria / Gammaproteobacteria / Pseudomonadales / Moraxellaceae / Moraxella Moraxella species are Gram‐negative rods or cocci but often with a tendency to resist decolorization. The rods are often very short and plump, frequently approaching a coccus shape (1.0–1.5 × 1.5–1.5 μm); they usually occur in pairs and short chains. Variation in cell size, shape, and filament or chain formation is often seen in cultures, the pleomorphism being enhanced by lack of oxygen and by incubation temperatures above the optimum. The cocci are usually smaller (0.6–1.0 μm in diameter) and occur as single cells or in pairs; sometimes results in the formation of tetrads. Flagella are absent. Both coccal and rod‐shaped species can be fimbriated. Absence of swimming motility, but surface‐bound “twitching motility” has been observed in some rod‐shaped species. Aerobic, but some species can grow weakly under anaerobic conditions. May be encapsulated. Chemoorganotrophic. Most species are nutritionally fastidious, and all grow in complex media; some are stimulated significantly by fatty acids (bile salts and Tween 80). The optimal temperature for growth is between 33 and 35°C. Colonies are not pigmented. Oxidase‐positive. Usually catalase‐positive. No acid is produced from carbohydrates. Species of this genus share 96–99% similarity in their 16S rRNA gene sequences. The major fatty acids in most species are C 18 :1 ω9 c and C 16:1 ω7 c . The major quinone is Q‐8. Members of the class Gammaproteobacteria and family Moraxellaceae . Parasitic on the mucous membranes of humans and other warm‐blooded animals. DNA G + C content (mol%) : 40–48.1 ( T m , Bd, HPLC). Type species : Moraxella lacunata Lwoff 1939 AL , synonym: “ Bacillus lacunatus ” Eyre 1900.

show abstract

Vaccine targets againstMoraxella catarrhalis

Cited by 32 publications

References 115 publications

Bronchiectasis in Children: Current Concepts in Immunology and Microbiology

Bronchiectasis in Children: Current Concepts in Immunology and Microbiology

Immunogenicity of trimeric autotransporter adhesins and their potential as vaccine targets

Moraxella

Contact Info

Product

Resources

About