Vaccination for Recurrent Herpes Simplex Infection

Lazar, Mariana

doi:10.1001/archderm.1956.01550010072010

Cited by 38 publications

(3 citation statements)

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“…There are several conceivable reasom,. none of which sa1i..,fac101 ily explaim, why our incrdence of contac1 dermatitis is less than that reported (4). These authors u!>ed repeated insult patch te:,b which were performed on the upper arm; at this site, therc is litlle lipid.…”

mentioning

confidence: 84%

Herpes simplex infection simulating a positive auto-inoculation for Haemophilus ducreyi

Jørgensen,

Menné

1982

Acta Derm Venereol

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Auto-inoculation from a genital ulcer suspected of being ulcus molle gave redness after 24 hours and after 48 hours vesicles and pustules appeared. Cultivation from the auto-inoculation after the 48 hours was positive for herpes simplex virus type 2. Our observation underlines two points: auto-inoculation for the diagnosing of Haemophilus ducreyi infection may be mimicked by herpes simplex infection, and the incubation period of herpes simplex can be shorter than the 4-5 days usually given.

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mentioning

confidence: 84%

Herpes simplex infection simulating a positive auto-inoculation for Haemophilus ducreyi

Jørgensen,

Menné

1982

Acta Derm Venereol

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“…Indeed, the inoculation of vesicle fluid into the forearm skin and the production of 'takes' was once an accepted therapeutic measure (Paulian, 1932;Hruszek, 1933;Lazar, 1956;Goldman, 1961) and the literature abounds with examples of similar experience in laboratory animals. Naturally occurring exogenous infections include some cases of traumatic herpes, including herpetic whitlows (Stern et al, 1959;Davies and Longson, 1970) and herpes gladiatorum (Porter and Baughman, 1965;Wheeler and Cabaniss, 1965).…”

Section: Exogenous Infectionmentioning

confidence: 99%

Persistence in herpes simplex virus infections

Longson¹

1978

Postgraduate Medical Journal

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Summary Diseases of man caused by the virus of herpes simplex fall into two broad categories. The primary disease occurs only once in any individual's life and is caused by transmission of virus from an already infected human. Thereafter, the individual may be subject to recurrent herpetic disease, the manifestations of which are different from the primary disease. Recurrent disease varies in severity from trivial, to incapacitating and frankly lethal (as in diseases resulting from the virus's neurotropic and oncogenic properties). The source of the virus in recurrent herpetic disease has never been conclusively resolved, but is almost certainly endogenous to the patient. Theories, case reports and experiments exist to show that endogenous virus may, in periods of clinical quiescence, be latent (or persistent) at the site of the recurrent lesions itself, or more remotely in nerve tissues related to the site of recurrence.

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“…Immunological techniques, either by repeated autoinoculation of successive lesions as advocated by Hruszek (1933) or by multiple smallpox vaccinations as demonstrated by Schiff and Kern (1954) and earlier workers, are no longer regarded by most dermatologists as acceptable or effective forms of treatment. Lazar (1956) showed that a new disease site could be initiated after the use of unmodified material containing the live virus, and Kern and Schiff (1959) have negatived their earlier work by a controlled trial where they managed to " cure " nearly as many patients with a heatkilled inactive vaccine as with the active vaccine. These workers suggest that any benefit obtained may have been due to inoculation of foreign protein or other substances within the vaccine or to "suggestion."…”

Section: Discussioamentioning

confidence: 99%