Vaccination against
            <i>Salmonella</i>
            infections in food animals: rationale, theoretical basis and practical application.

Barrow, Paul; Methner, Ulrich

doi:10.1079/9781845939021.0455

Cited by 15 publications

(18 citation statements)

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“…Whilst many experimental challenge studies have been reported involving candidate Salmonella vaccines [13,14], relatively few have involved field studies, and still fewer have tackled field situations with broad host range serovars, such as are often seen in modern pig production. Among these, Arguello et al [15] used an inactivated ST DT104 vaccine injected into grower pigs and demonstrated significant reductions in ST shedding after vaccination and in colonisation of mesenteric lymph nodes and caecum at slaughter, although Salmonella of other serogroups was not significantly reduced.…”

Section: Introductionmentioning

confidence: 99%

Use of an attenuated live Salmonella Typhimurium vaccine on three breeding pig units: A longitudinal observational field study

Davies

Gosling

Wales

et al. 2016

Comparative Immunology, Microbiology and Infectious Diseases

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Section: Introductionmentioning

confidence: 99%

Use of an attenuated live Salmonella Typhimurium vaccine on three breeding pig units: A longitudinal observational field study

Davies

Gosling

Wales

et al. 2016

Comparative Immunology, Microbiology and Infectious Diseases

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“…An important requirement for the new generation of live oral vaccines is to be distinguishable from field isolates by inducing a different serological host response (Barrow and Wallis, 2000). The most straightforward solution to provide a negative serological marker for a Salmonella strain is the elimination of flagellae.…”

Section: Discussionmentioning

confidence: 99%

“…These findings are in line with the in vivo results of Gulig and Curtiss (1987) and of Imre et al (2007). However, based on the recent evidences and the potential public health aspects the elimination of the serovar-specific virulence plasmid should be regarded as an advantage for the development and registration of live oral Salmonella vaccines (Martin et al, 1996;Barrow and Wallis, 2000).…”

Section: Inhibition (%)mentioning

confidence: 99%

“…Killed vaccines confer strong protection primarily against host-restricted Salmonella serovars such as S. Gallinarum in poultry (Barrow and Wallis, 2000) but also against the in ovo transmission of S. Enteritidis (EFSA, 2007). This is probably due to the fact that killed vaccines induce good humoral immune responses which may be sufficient against septicaemia and related clinical disease.…”

mentioning

confidence: 99%

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Vaccine potential of a nonflagellated, virulence-plasmid-cured (fliD–, pSEVΔ) mutant of Salmonella Enteritidis for chickens

Imre

Szmolka

Olasz

et al. 2015

Acta Veterinaria Hungarica

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The aim of these studies was to assess residual virulence and early protective capacity of a negatively markered live attenuated vaccine candidate Salmonella Enteritidis mutant against a highly virulent S. Enteritidis strain using a dayold chicken model. Nonflagellated FliD negative mutants of Salmonella Enteritidis 11 (SE11) with and without the virulence plasmid proved to be sufficiently attenuated (limited invasiveness in vitro/in vivo) without reduced ability to colonise chicken gut. The early protective activity of a nonflagellated, virulence-plasmidcured (fliD-, pSEV∆) mutant against organ invasion, caecal colonisation and faecal shedding by the highly virulent challenge strain S. Enteritidis 147 Nal R proved to be effective and safe. The innate and adaptive immunity was demonstrable during the first four weeks of life, and the serological response was clearly distinguishable from the response induced by the wild parental strain. In conclusion, we provided data for the first time about a virulence-plasmid-cured, nonflagellated mutant of S. Enteritidis to serve as a basis for development of a negatively markered potential live oral vaccine against virulent S. Enteritidis in chicken.

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“…Nevertheless, more constructive approaches are anticipated; of which extensive researches are currently on-going to pave a way for efficient subunit vaccines production that takes consumer safety concerns into account. It is because the issue is previously neglected in terms of antibiotics and live-attenuated strain vaccines application [6]. Pathogenicity of host-adapted Salmonella gallinarum is primarily noted through the epidemic spread of fowl typhoid (FT) in chickens and turkeys, often instigating high morbidity and mortality rates.…”

mentioning

confidence: 99%

Partial Characterization of Salmonella gallinarum Clinical Isolate and Expression of Its Antigenic Outer Membrane Protein C (ompC) Gene in planta

Pang¹,

Loh²

2015

JTLS

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Fowl typhoid's epidemiology and disease intervention have been extensively studied since 1950's owing to its high mortality and morbidity rates. Even up-to-date, outbreaks are incessantly haunting poultry industries of major continents. Salmonella gallinarum, the etiologic agent of fowl typhoid, was used to develop a series of vaccination regime. However, treatments are gradually losing effectiveness due to residual virulence from mutated strains and rapid evolution of multi-drug resistance isolates. Hence, in planta subunit vaccine production is proposed to surpass current limitations. The homotrimeric osmoporin (outer membrane protein C) is a potent candidate antigen that confers momentous stimulation of humoral and cell-mediated immune responses in broilers. This research signified the potential development of a plant-expressed OmpC immunogen. The project scope embarked on the identification of S. gallinarum clinical isolate, construction of expression cassette and delivery of constructs into Nicotiana benthamiana via agroinfiltration. The OmpC transcripts and proteins were detected successfully at the molecular weights of ~1.002 kbp and ~35 kDa, respectively. These preliminary findings pave the feasibility of biomanufacturing a safe and cost-effective fowl typhoid vaccine that would confer multi-protection against other significant Salmonella infections attributed to the high sequence homology of the OmpC gene. Speed improvement is demonstrated and transient expression appears to outperform conventional platforms in expediting vaccine production for an emerging pandemic strain.

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Vaccination against Salmonella infections in food animals: rationale, theoretical basis and practical application.

Abstract: The development, use and factors that influence the efficacy of vaccines to control salmonellosis in poultry, pigs, cattle and sheep are discussed.

Cited by 15 publications

References 0 publications

Use of an attenuated live Salmonella Typhimurium vaccine on three breeding pig units: A longitudinal observational field study

Use of an attenuated live Salmonella Typhimurium vaccine on three breeding pig units: A longitudinal observational field study

Vaccine potential of a nonflagellated, virulence-plasmid-cured (fliD–, pSEVΔ) mutant of Salmonella Enteritidis for chickens

Partial Characterization of Salmonella gallinarum Clinical Isolate and Expression of Its Antigenic Outer Membrane Protein C (ompC) Gene in planta

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