Vaccine potential of a nonflagellated, virulence-plasmid-cured (fliD–, pSEVΔ) mutant of Salmonella Enteritidis for chickens

Imre, Ariel; Szmolka, Ama; Olasz, Ferenc; Nagy, Béla

doi:10.1556/004.2015.027

Cited by 5 publications

(5 citation statements)

References 34 publications

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“…The deposited genome contigs of the emerging strain SI54/04 (Olasz et al, 2015) were 104 used for the extraction of specific regions of plasmid pSI54/04 with functions in antimicrobial 105 resistance, virulence, plasmid maintenance and transfer. As a reference for the assembly of 106 these plasmidic regions, the corresponding contigs (ASRF01000099 -ASRF01000108) of the 107 published megaplasmid pESI from an Israeli MDR strain of human S. Infantis were used 108 (Aviv et al, 2014).…”

Section: Sequence Analysis Of Specific Regions and Pcr-typing Of Plasmentioning

confidence: 99%

Molecular epidemiology of the endemic multiresistance plasmid pSI54/04 of Salmonella Infantis in broiler and human population in Hungary

et al. 2018

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1Salmonella Infantis (SI) became endemic in Hungary where the PFGE cluster B, 2 characterized by a large multiresistance (MDR) plasmid emerged among broilers leading to 3 an increased occurrence in humans. We hypothesised that this plasmid (pSI54/04) assisted 4 dissemination of SI. Indeed, Nal-Sul-Tet phenotypes carrying pSI54/04 occurred increasingly 5 between 2011-2013 among SI isolates from broilers and humans. Characterization of 6 pSI54/04 based on genome sequence data of the MDR strain SI54/04 indicated a size of ~277 7 kb and a high sequence similarity with the megaplasmid pESI of SI predominant in Israel. 8Molecular characterization of 78 representative broiler and human isolates detected the 9 prototype plasmid pSI54/04 and its variants of together with novel plasmid associations 10 within the emerging cluster B. To test in vitro and in vivo pathogenicity of pSI54/04 we 11 produced plasmidic transconjugant of the plasmid-free pre-emergent strain SI69/94. This 12 parental strain and its transconjugant have been tested on chicken embryo fibroblasts (CEFs) 13 and in orally infected day old chicks. The uptake of pSI54/04 did not increase the 14 pathogenicity of the strain SI69/94 in these systems. Thus, dissemination of SI in poultry 15 could be assisted by antimicrobial resistance rather than by virulence modules of the endemic 16 plasmid pSI54/04 in Hungary. 17

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Section: Sequence Analysis Of Specific Regions and Pcr-typing Of Plasmentioning

confidence: 99%

Molecular epidemiology of the endemic multiresistance plasmid pSI54/04 of Salmonella Infantis in broiler and human population in Hungary

et al. 2018

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“…In two live vaccine studies, there was no protection against heterologous challenge (Penha et al, 2010;Wolfenden et al, 2010). Numerous studies described other live-attenuated vaccines that protected against S. Typhimurium and/or S. Enteritidis (De Cort et al, 2013;De Cort et al, 2015;De Cort et al, 2014;Imre et al, 2015;Rubinelli et al, 2015). In one study, passive immunization using in-feed IgY had no effect on Salmonella (Chalghoumi et al, 2009).…”

Section: Salmonella Immunizationmentioning

confidence: 99%

“…Salmonella 4 (Berghaus et al, 2011;El-Ghany et al, 2012;Kogut et al, 2012;Pavic et al, 2010) 0 8 (De Cort et al, 2013;De Cort et al, 2015;De Cort et al, 2014;Hayashi, Tujimoto-Silva, et al, 2018;Imre et al, 2015;Muniz et al, 2017;Penha et al, 2010;Rubinelli et al, 2015) 2 (Wolfenden et al, 2010;Yang et al, 2017) 1 (Chalghoumi et al, 2009) 1 (Dorea et Layton et al, 2011;Nothaft et al, 2017) 1 (Hermans et al, 2014) 0 ceca to below the detection limit (Annamalai et al, 2013;Layton et al, 2011), while the remainder saw reductions of 0.64-3 log 10 CFU/g cecal contents (Hodgins et al, 2015;Kobierecka et al, 2016;Neal-McKinney et al, 2014;Singh et al, 2019;Taha-Abdelaziz et al, 2018). Notably in one study, the combination of probiotics with a vaccine candidate led to an average ∼7 log 10 CFU/g reduction, with C. jejuni below detection levels in the majority of birds, significantly more effective than separate use of the vaccine or probiotics alone (2 log 10 CFU/g reduction and no change at all, respectively) (Nothaft et al, 2017).…”

Section: Live Recombinant Passive Combinationmentioning

confidence: 99%

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Advances in enteropathogen control throughout the meat chicken production chain

Stewart¹,

Pavic²

2023

Comp Rev Food Sci Food Safe

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Enteropathogens, namely Salmonella and Campylobacter, are a concern in global public health and have been attributed in numerous risk assessments to a poultry source. During the last decade, a large body of research addressing this problem has been published. The literature reviewed contains review articles on certain aspects of poultry production chain; however, in the past decade there has not been a review on the entire chain-farm to fork-of poultry production. For this review, a pool of 514 articles were selected for relevance via a systematic screening process (from >7500 original search articles). These studies identified a diversity of management and intervention strategies for the elimination or reduction of enteropathogens in poultry production. Many studies were laboratory or limited field trials with implementation in true commercial operations being problematic. Entities considering using commercial antienteropathogen products and interventions are advised to perform an internal validation and fit-for-purpose trial as Salmonella and Campylobacter serovars and biovars may have regional diversity. Future research should focus on nonchemical application within the processing plant and how a combination of synergisticinterventions through the production chain may contribute to reducing the overall carcass burden of enteropathogens, coupled with increased consumer education on safe handling and cooking of poultry.

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“…In two live vaccine studies, there was no protection against heterologous challenge [351,354]. Numerous studies described other live-attenuated vaccines that protected against S.Typhimurium and/or S.Enteritidis [346][347][348]350,352]. In one study, passive immunisation using in-feed IgY had no effect on Salmonella [355].…”

Section: Immunisationmentioning

confidence: 99%

Advances in Enteropathogen Control Throughout the Meat Chicken Production Chain

Stewart¹,

Pavic²

2022

Preprint

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Enteropathogens, namely Salmonella and Campylobacter, are a concern in global public health and have been attributed in numerous risk assessments to a poultry source. During the last decade a large body of research addressing this problem has been published. The literature reviewed contains review articles on certain aspects of poultry production chain, however in the past decade there hasn’t been a review on the through production chain, farm to fork, production of poultry. This review, a pool of 514 articles were selected for relevance via a systematic screening process (from >7500 original search articles). These studies identified a diversity of management and intervention strategies for the elimination or reduction of enteropathogens in poultry production. Many studies were laboratory or limited field trials with implementation in true commercial operations being problematic. Entities considering using commercial anti-enteropathogen products and interventions are advised to perform an internal validation and fit for purpose trial as Salmonella and Campylobacter serovars and biovars may have regional diversity. Future research should focus on non-chemical application within the processing plant and how synergistic through chain intervention may contribute to reducing the overall carcass burden of enteropathogen, coupled with increased consumer education on safe handling and cooking of poultry.

show abstract

Vaccine potential of a nonflagellated, virulence-plasmid-cured (fliD–, pSEVΔ) mutant of Salmonella Enteritidis for chickens

Cited by 5 publications

References 34 publications

Molecular epidemiology of the endemic multiresistance plasmid pSI54/04 of Salmonella Infantis in broiler and human population in Hungary

Molecular epidemiology of the endemic multiresistance plasmid pSI54/04 of Salmonella Infantis in broiler and human population in Hungary

Advances in enteropathogen control throughout the meat chicken production chain

Advances in Enteropathogen Control Throughout the Meat Chicken Production Chain

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