Vaccination against hepatitis B among prisoners in Iran: Accelerated vs. classic vaccination

Asli, Ali Asghar Zolghadr; Moghadami, Mohsen; Zamiri, Nima; Tolide-ei, Hamid Reza; Heydari, Seyed Taghi; Alavian, Seyed Moayed; Lankarani, Kamran Bagheri

doi:10.1016/j.healthpol.2010.12.007

Cited by 15 publications

(22 citation statements)

References 25 publications

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“…Traditional vaccination scheme is three doses administered on the 0-1-6th months or four doses administered on the 0-1-2-12th months. Nevertheless, recent studies have investigated administration of three doses on days 0-7-21 or 0-10-21 with a booster dose in 12 months to subjects traveling to HBV endemic regions, those with an irregular former vaccine scheme, and subjects who need a rapid antibody response with positive results [13–15]. Bock et al used three different vaccine schemes: 0-1-2nd day (group A), 0-14-28th day (group B), and 0-7-21st day (group C).…”

Section: Discussionmentioning

confidence: 99%

Rapid Immunization Scheme for Spouses of Individuals Estabilished as Hepatitis B Carriers during Premarital Tests

Tosun¹,

Yücetürk²,

Dönmez³

et al. 2012

Clinical and Developmental Immunology

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Background. The aim of this study was to monitor the cases identified as hepatitis B carriers during premarital tests, to vaccinate their prospective spouses with a rapid vaccination scheme, and to compare the anti-HBs responses with the traditional vaccination scheme. Methods. Blood samples of 1250 couple spouses were tested for HBsAg and anti-HBs. HBsAg positive cases' fiancées which were found HBV negative were administered a rapid three-dose vaccination scheme on days 0, 7, and 21. Forty controls with similar age and gender were also were administered three doses of the same vaccine. Results. Out of 1250 cases (625 couples), 46 (3.6%) were HBsAg positive, and 40 of them aged between 18 and 39 were admitted to the rapid vaccination program. Conclusion. Upon determination of HBsAg positivity in premarital tests, a rapid vaccination program provides early protection, but the 6th and 12th month vaccinations are also required. Anti-HBs response should be monitored.

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Section: Discussionmentioning

confidence: 99%

Rapid Immunization Scheme for Spouses of Individuals Estabilished as Hepatitis B Carriers during Premarital Tests

Tosun¹,

Yücetürk²,

Dönmez³

et al. 2012

Clinical and Developmental Immunology

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“…Prisoners and IDUs are at constant risk of HBV infection, and the classic 6-month HBV vaccination might not provide immunization rapidly enough 4,5 . Compared with classic HBV vaccination regimen, an accelerated 0, 1, 4, and 8 weeks vaccination schedule can achieve early seroprotection more rapidly, provides clinically sufficient seroprotection with higher compliance in prisoners, and can be suggested in situations that rapid immunization against HBV infection is warranted 4 .…”

Section: Seyed Moayed Alavian 1 Dear Editormentioning

confidence: 99%

“…Compared with classic HBV vaccination regimen, an accelerated 0, 1, 4, and 8 weeks vaccination schedule can achieve early seroprotection more rapidly, provides clinically sufficient seroprotection with higher compliance in prisoners, and can be suggested in situations that rapid immunization against HBV infection is warranted 4 . I suggest the selection of higher-risk groups in prisons, including males with history of IDUs and STD, to start the accelerated vaccination against HBV infection early.…”

Section: Seyed Moayed Alavian 1 Dear Editormentioning

confidence: 99%

Accelerated vaccination against HBV infection is an important strategy for the control of HBV infection in prisons

Alavian

2011

Rev. Soc. Bras. Med. Trop.

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Vacinação rápida contra a infecção por VHB é uma estratégia importante para o controle da infecção pelo VHB em presídios Seyed Moayed Alavian 1 Dear Editor:I read with interest the article by Stief et al. published in your journal recently 1 . It showed us that hepatitis B virus (HBV) infection remains a significant problem in prisons, and it was related with other published studies 2,3 . The finding on higher prevalence of HBV infection in the male gender and in prisoners with positive history of intravenous drug use and STD demonstrated a new strategy for the control of HBV infection in prisons. Low vaccination coverage and the high number of injecting drug users (IDUs) suggest that most of them are susceptible to this infection.Prisoners and IDUs are at constant risk of HBV infection, and the classic 6-month HBV vaccination might not provide immunization rapidly enough 4,5 . Compared with classic HBV vaccination regimen, an accelerated 0, 1, 4, and 8 weeks vaccination schedule can achieve early seroprotection more rapidly, provides clinically sufficient seroprotection with higher compliance in prisoners, and can be suggested in situations that rapid immunization against HBV infection is warranted 4 . I suggest the selection of higher-risk groups in prisons, including males with history of IDUs and STD, to start the accelerated vaccination against HBV infection early. This will be extremely useful to ensure immunity against HBV infection soon.I would like to inform those identified by Stief et al. as having high risk of contracting HBV infection, particularly those in prisons and of old age, that being infected would be related to more duration of staying in high-risk place (prison) and more exposure with the risk factors. And finally, I would like to ask about hepatitis C virus (HCV) and HIV infections, which are more common in IDU groups 6 as stated in the literature; the authors did not present this in their study. A total of 408 individuals were interviewed regarding sociodemographic characteristics, associated factors and HBV vaccination using a standardized questionnaire. Blood samples were collected from all participants and serological markers for HBV were detected by enzyme-linked immunosorbent assay. Hepatitis B surface antigen (HBsAg) and/or antibodies against hepatitis B core antigen (anti-HBc) positive samples were tested for HBV-DNA by polymerase chain reaction. Results:

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“…Worldwide, the standard hepatitis B vaccination schedule for adults consists of three doses administered on a 0–1–6 month schedule, which typically results in at least 85% seroprotection in target groups [ 4 ]. Unfortunately, despite longstanding recommendations, it remains difficult to reach at-risk groups due to some factors including lack of self-protection cognition and limited healthcare programs targeting certain high-risk groups such as injection drug users and prisoners.…”

Section: Introductionmentioning

confidence: 99%

“…However, one major concern with accelerated vaccination schedules is whether the protection persists similarly to standard vaccination schedules. Moreover, various short schedules, such as 0–1–2 months [ 7 – 14 ], 0–1–2–6 months [ 15 , 16 ], 0–1–2–12 months [ 15 , 17 – 22 ], 0–1–12 months [ 20 , 23 ], 0–1–4 months [ 24 , 25 ], 0–14–42 days [ 26 ], 0–7–21 days [ 27 – 31 ], 0–7–28–56 days [ 4 ], and 0–7–21–360 days [ 32 ], administered to medical students, health-care workers, prisoners, drug users, dialysis patients, and patients with HIV complicate determination of the optimal choice of an accelerated schedule.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Accelerated and Standard Hepatitis B Vaccination Schedules in High-Risk Healthy Adults: A Meta-Analysis of Randomized Controlled Trials

et al. 2015

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BackgroundSelecting the most efficient vaccination schedule is an important issue.ObjectiveTo assess the beneficial and harmful effects of accelerated hepatitis B vaccination schedules in high-risk healthy adults.MethodsWe searched controlled trial registers of The Cochrane Library as well as MEDLINE, EMBASE, VIP Database for Chinese Technical Periodicals, and the Chinese National Knowledge Infrastructure databases for randomized controlled trials published up to December 2013 that compared accelerated hepatitis B vaccine schedules to the standard schedule in adults. The results were presented as relative risk with 95% confidence intervals. Fixed or random effect models were used for analysis.ResultsWe identified 10 randomized trials, all with one or more methodological weaknesses. Compared to the standard schedule, most accelerated schedules resulted in higher proportions of healthy vaccines more rapidly reaching anti-hepatitis B antibody levels >10 IU/L (P<0.05) initially and maintaining similar seroprotection rates after 6 months (P>0.05). Although accelerated schedules produced anti-hepatitis B levels higher than the standard schedule for the first month after the initial vaccine dose, they were significantly lower than the standard schedule after 6 months, except for an accelerated schedule that called for a fourth booster injection 12 months after the initial dose. Subjects administered accelerated vaccine schedules had similar compliance rate as those administered the standard schedule over the first 6 months of vaccination (relative risk = 1.00, 95% confidence interval: 0.84–1.21).ConclusionFor rapid seroconversion and almost immediate short-term protection, accelerated vaccination schedules could be useful for at-risk groups. However, additional studies on the long-term protection and effectiveness of the primary doses of accelerated schedules are necessary.

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Vaccination against hepatitis B among prisoners in Iran: Accelerated vs. classic vaccination

Cited by 15 publications

References 25 publications

Rapid Immunization Scheme for Spouses of Individuals Estabilished as Hepatitis B Carriers during Premarital Tests

Rapid Immunization Scheme for Spouses of Individuals Estabilished as Hepatitis B Carriers during Premarital Tests

Accelerated vaccination against HBV infection is an important strategy for the control of HBV infection in prisons

Comparison of Accelerated and Standard Hepatitis B Vaccination Schedules in High-Risk Healthy Adults: A Meta-Analysis of Randomized Controlled Trials

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