A AB BS ST TR RA AC CT T O Ob bj je ec ct ti iv ve e: : Tetanus is a disease that can be prevented with vaccination, but protective antitoxin titers decrease to undetectable levels with old age. The aim of this study is to evaluate tetanus antitoxin levels in individuals over 40 years of age and to investigate the vaccination and physical injury status via survey. M Ma at te er ri ia al l a an nd d M Me et th ho od ds s: : A total of 361 participants, 178 men and 183 women, were enrolled in the study and blood was drawn from each participant to measure tetanus antibody level by enzyme immunoassay (EIA) method. R Re es su ul lt ts s: : Tetanus antibodies were undetectable in 55 male (30.9%) and 71 female patients (38.8%) at the end of the study. It was determined that tetanus antitoxin levels significantly decrease with age in both women and men especially after 50 years of age which is accepted as the limit age in which antibody is likely to be negative. C Co on nc cl lu us si io on n: : In adult age group, booster vaccination for tetanus is recommended every 10 years in developing and developed countries, but this recommendation can not be put into practice as anticipated. Similarly in our country, vaccination of adult age group is not common and tetanus vaccine is not generally administered at every ten years. The results of this study show that one dose of tetanus vaccine should be administered at least to individuals over 50 years of age, and individuals who do not recall their vaccination history should be taken into a three-dose vaccination program.K Ke ey y W Wo or rd ds s: : Diphtheria-tetanus vaccine; tetanus antitoxin; tetanus toxoid Ö ÖZ ZE ET T A Am ma aç ç: : Tetanoz aşı ile önlenebilir bir hastalıktır fakat yaşla beraber koruyucu antitoksin titreleri saptanamayacak düzeylere düşer. Bu çalışmanın amacı 40 yaşın üzerindeki bireylerde tetanoz antitoksin düzeylerini değerlendirmektir. G Ge er re eç ç v ve e Y Yö ön nt te em ml le er r: : Bu çalışmada 178 erkek ve 183 kadından oluşan toplam 361 katılımcıdan alınan kan örneklerinde enzim immunoassay (EIA) yöntemiyle tetanoz antitoksin düzeyleri çalışılmıştır. B Bu ul lg gu ul la ar r: : Tetanoz antikorunun erkeklerin 55 (%30,9)'inde ve kadınların 71 (%38,8)'inde ölçülemeyecek düzeyde olduğu, tetanoz antitoksin düzeylerinin kadınlar ve erkeklerde yaşla beraber azaldığı ve özellikle sınır yaş olarak kabul edilen 50 yaş ile beraber negatif olduğu saptanmıştır. S So on nu uç ç: : Erişkin yaş grubunda gelişmiş ve gelişmemiş ülkelerde tetanoz için her 10 yılda bir rapel aşılaması önerilmesine karşın bu öneri yeterince uygulanamamaktadır. Ülkemizde de erişkinlerin aşılanması yaygın olmayıp 10 yılda bir tetanoz rapeli yeterince yapılamamaktadır. Çalışmamızın sonuçları 50 yaş üzerindeki bireylere en az bir doz tetanoz aşısı uygulanması gerekliliğini ve aşılama geçmişini hatırlamayan bireyler için üç doz aşılama programı uygulanmasının faydalı olacağını düşündürmektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Difteri-tetanoz aşısı; tetanoz antitoksini...
Background. The aim of this study was to monitor the cases identified as hepatitis B carriers during premarital tests, to vaccinate their prospective spouses with a rapid vaccination scheme, and to compare the anti-HBs responses with the traditional vaccination scheme. Methods. Blood samples of 1250 couple spouses were tested for HBsAg and anti-HBs. HBsAg positive cases' fiancées which were found HBV negative were administered a rapid three-dose vaccination scheme on days 0, 7, and 21. Forty controls with similar age and gender were also were administered three doses of the same vaccine. Results. Out of 1250 cases (625 couples), 46 (3.6%) were HBsAg positive, and 40 of them aged between 18 and 39 were admitted to the rapid vaccination program. Conclusion. Upon determination of HBsAg positivity in premarital tests, a rapid vaccination program provides early protection, but the 6th and 12th month vaccinations are also required. Anti-HBs response should be monitored.
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