Rapid Immunization Scheme for Spouses of Individuals Estabilished as Hepatitis B Carriers during Premarital Tests

Tosun, Selma; Yücetürk, Murat; Dönmez, Aydın Bilal; Gündüz, Turgut

doi:10.1155/2012/843134

Cited by 4 publications

(2 citation statements)

References 16 publications

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“…In the current study, the high HBsAg prevalence of the participants (12.56%) suggested that married couples could be categorised into a high-epidemic group, and this was concordant with previous findings from the Pearl River Delta in 2016, in which the HBsAg prevalence was 12.71% among residents aged 23–59 years 5. However, when compared with the couples reported in other studies, the HBsAg prevalence in this study was much higher than that of rural couples in China (4.80%~6.07%) and married couples in other countries (1.7%~10.9%) 12–14 17–22. All of these implied the relatively high HBV burden of this population in Guangdong, which presents a significant public health threat and requires urgent interventions.…”

Section: Discussionsupporting

confidence: 89%

Epidemiology of hepatitis B virus infection among preconception couples in South China: a cross-sectional study

et al. 2023

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ObjectivesHepatitis B virus (HBV) infection is a global public health threat, and couples of reproductive age comprise a key population in aiming to reduce both the vertical and horizontal transmission of HBV. We aimed to update knowledge on the seroepidemiology status of HBV in Guangdong, China among a large number of couples planning conception, and to identify high-risk subgroups.DesignA cross-sectional study was performed in Guangdong, China from 2014 to 2017.SettingThe data were collected from 641 642 couples (1 283 284 individuals) participating in the National Free Preconception Health Examination Project in Guangdong, China from 1 January 2014 to 31 December 2017. For each participant, sociodemographic data were obtained and a serum sample was tested for HBV infection status.Results161 204 individuals (12.56%) were positive for hepatitis B surface antigen (HBsAg+), and 47 318 (3.69%) were positive for both HBsAg and hepatitis B e antigen (HBsAg+ and HBeAg+). There was a higher prevalence of HBsAg+ (12.77% vs 9.42%, p<0.05) and HBsAg+ and HBeAg+ (3.77% vs 2.45%, p<0.05) among the participants with a Guangdong household registration than a non-Guangdong household registration. Similarly, the prevalence of HBsAg (13.26% vs 11.72%, p<0.05) and HBsAg+ and HBeAg+ (4.31% vs 2.94%, p<0.05) was higher among participants not living in the Pearl River Delta than those living in the Pearl River Delta. At the couple level, 12 446 couples (1.94%) were both positive; in 51 849 (8.08%), only the wife was positive; in 84 463 (13.16%), only the husband was positive. Moreover, HBsAg+ prevalence was lowest in couples where both individuals were vaccinated (18.63%) and highest in couples where neither the wife or husband was vaccinated (24.46%).ConclusionThere was a relatively high HBsAg+ prevalence in married couples in this high-epidemic region and urgent prevention strategies are required, such as ensuring access to health services for those not living in the Pearl River Delta, and expanding vaccine programmes to high-risk adults.

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Section: Discussionsupporting

confidence: 89%

Epidemiology of hepatitis B virus infection among preconception couples in South China: a cross-sectional study

et al. 2023

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“…Ten more were subsequently excluded because they were irrelevant to the current research question. Specifically, 5 studies addressed the prevalence and management of hepatitis antigen positivity in a specific population,11-15 2 measured incidence trends or population perception of hepatitis B and C before any hepatitis PSP had been established,16,17 2 targeted diseases other than hepatitis,18,19 and one assessed physicians’ attitudes toward general HCV screening 20. One further study was excluded because it mainly discussed risk factors for transmission in the community and not screening for the viruses 21.…”

Section: Methodsmentioning

confidence: 99%

Premarital hepatitis screening

Alharbi

Aljarallah

2018

SMJ

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Objective:To explore all research articles investigating hepatitis premarital screening programs (PSPs) worldwide, considering all different outcomes of such programs, including efficacy, possible limitations to screening, and participants’ knowledge and satisfaction regarding the program.Methods:The present systematic review used the databases of PubMed, Ovid Medline, and Google Scholar to search for articles related to both PSPs and the hepatitis viruses. Research articles were identified between October and December 2017, and articles were selected and extracted based on predefined inclusion and exclusion criteria from the year 1957 up to 2017. The review included all full-length original articles related to premarital hepatitis screening in both indexed and non-indexed journals, but reviews, mini-reviews, and letters were excluded. Ultimately, 4 research papers were included. While conducting the search, the project was registered on PROSPERO database.Results:In all these papers, the participants’ attitude toward premarital screening was good, but their level of knowledge about the program and the diseases being screened was low. Pre- and post-test counseling were provided to only a limited number of participants in each of the studies. This emphasizes the need for effective counseling sessions, which may help in decreasing the hepatitis burden in Saudi Arabia and worldwide.Conclusions:The role of the practicing physician in any screening program is to provide effective pre and post-test counseling and correct any misinformation about the transmission of the hepatitis viruses. PROSPERO Registration number: CRD42018096535

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Low prevalence, low immunization and low adherence to full hepatitis B vaccine scheme and high-risk behaviors among crack cocaine users in central Brazil

Silva

França

Del-Rio

et al. 2017

Journal of Infection and Public Health

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Crack cocaine users represent a target group for hepatitis B vaccination. We evaluate the HBV epidemiology, immunization status and compliance with a super-accelerated vaccination schedule among in-treatment crack cocaine users in central Brazil. Six hundred in-treatment crack cocaine users were interviewed, and serum samples were tested for HBV markers. A super-accelerated vaccination schedule of HBV vaccine was offered to all susceptible crack cocaine users. In total, 7.0% of those tested had at least one positive marker of HBV exposure. Age, use of crack cocaine through improvised pipe, exchange of sex for money/drugs and previous sexually transmitted infections (STIs) were predictors of HBV exposure. One hundred six (17.7%) individuals showed a serological profile of hepatitis B vaccination. Of these, 54.7% were less than 25 years old, and only 13% of individuals were more than 35 years old. Although 91.8% of crack users accepted the first vaccine dose, only 21.7% received all three doses. Of the 23 crack cocaine users who agreed to have their vaccine response evaluated, 78.3% developed protective anti-HBs titers. Premature termination of treatment was the most common reason for not receiving the full vaccine series. Despite the low prevalence of HBV exposure among in-treatment crack cocaine users in central Brazil, the low rate of immunization and the high frequency of high-risk behaviors highlight the potential for crack users to acquire and disseminate this infection and therefore maintain the viral reservoir. Health practitioners need to keep this in mind, taking advantage of all opportunities to access this population and vaccinate against HBV.

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Rapid Immunization Scheme for Spouses of Individuals Estabilished as Hepatitis B Carriers during Premarital Tests

Cited by 4 publications

References 16 publications

Epidemiology of hepatitis B virus infection among preconception couples in South China: a cross-sectional study

Epidemiology of hepatitis B virus infection among preconception couples in South China: a cross-sectional study

Premarital hepatitis screening

Low prevalence, low immunization and low adherence to full hepatitis B vaccine scheme and high-risk behaviors among crack cocaine users in central Brazil

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