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Zherebtsov, N. A.; Попова, Т. Н.; Zyablova, T. V.

doi:10.1023/a:1002819529281

Cited by 7 publications

(8 citation statements)

References 4 publications

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“…The first are redox agents that reduce the iron site, such as NDGA ( 14 ) and jasplaquinol ( 7 ) . The second are nonredox agents that bind at the active site such as the competitive inhibitor fumaric acid or at the allosteric site such as oleyl sulfate, boswellic acid, and 4-(2-oxapentadeca-4-yne)phenylpropanoic acid. 24…”

Section: Introductionmentioning

confidence: 99%

“…The first are redox agents that reduce the iron site, such as NDGA (14) 20 and jasplaquinol (7). 1 The second are nonredox agents that bind at the active site such as the competitive inhibitor fumaric acid 21 or at the allosteric site such as oleyl sulfate, 22 boswellic acid, 23 and 4-(2-oxapentadeca-4-yne)phenylpropanoic acid. 24 Remarkably, very few of the above natural product LO inhibitors or their congeners have been evaluated against multiple forms of the enzyme.…”

Section: Introductionmentioning

confidence: 99%

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Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 15-Soybean Lipoxygenases

et al. 2003

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To sharpen the search for new lipoxygenase inhibitors, we designed a screen to probe for both potency and selectivity. The assay utilized 12-human (12-HLO), 15-human (15-HLO), and 15-soybean (15-SLO) lipoxygenases. The IC(50) value data obtained provided new insights about structure-activity relationships (SAR) for redox and nonredox inhibitors. All of the compounds tested were isolated from sponges and consisted of a novel terpenoid, hyrtenone A (1), and 12 known terpenoids. Potent compounds were defined as those having IC(50) values < 1 microM, and selectivity was assessed from the three possible IC(50) value ratios. One of the four terpenoid redox inhibitors studied, puupehenone (2), was equivalent to or better in potency than the well-known redox inhibitor nordihydroguarierate acid (NDGA, 14). However, none of the terpene redox inhibitors exhibited a selectivity ratio on a par with that of 14. Several potent nonredox inhibitors were identified, and one, dimethoxypuupehenol (5), exhibited notable selectivity. The structural elucidation of 1 and the SAR results for 13 natural products are reported. This study suggests that sponge-derived terpenes are a promising source for new lipoxygenase inhibitors.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 15-Soybean Lipoxygenases

et al. 2003

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“…На основании имеющихся литературных данных [3,5,6,16] и полученных нами результатов представлен возможный механизм участия кремния в обменных процессах мышечной, соединительной и костной тканей (рис. 2).…”

Section: спортивное питаниеunclassified

Influence of Silicon-Containing Water ‘Ardvi’ on Wound Healing and Long-Term Delayed Onset Muscle Soreness

Tolmachev

Tichonov³

et al. 2017

HSM

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Введение. Современная система подготовки спортсменов характеризуется исключительно высокими тренировочными и соревновательными нагрузками [11]. Суммарный годовой объем работы в разных видах спорта достигает 1300-1500 часов, в отдельные дни проводятся 2-3 тренировочных занятия с общими временными затратами до 6-8 часов, что в целом составляет значительные трени-ровочные и соревновательные нагрузки. Например, в спортивных играх количество выступлений достигает 70-85 в год [17]. Такие нагрузки являются мощным фактором мобилизации функциональных резервов организма спортсменов, интенсивной стимуляции адаптационных процессов, направленных на повышение выносливости, силы, скоростных качеств и рост спортивных результа-Спортивное питание УДК 663.64

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“…To reduce the level of ROI, which are toxic to the plant organism, is the activation of lipid peroxidation reactions (LP) [5]. Activation of LP is one of the rapid and nonspecific reactions of living organism cells to the stress factors [6].…”

Section: Introductionmentioning

confidence: 99%

Influence of Biologically Active Substances on Key Indicators of the Conditions of Winter Wheat Ecocenosis

et al. 2021

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The article deals with the study of the effect of the application of the herbicide Granstar Gold 75, w.g. (water-soluble granulate) and plant growth regulator Regoplant on some ecological indicators of ecocenosis of winter wheat sowing (lipid peroxidation reactions in winter wheat plants by the activity of malonic dialdehyde content accumulation, enzymatic activity, total number of rhizosphere bacteria and anatomical structure of winter wheat leaves). The choice of research topic is due to the fact that currently obtaining high yields of winter wheat is closely connected to the widespread use of chemicals, in particular, herbicides, which by their nature are physiologically active substances that can affect both plants and soil microbiota. This, in turn, leads to the search for environmentally safe elements of technologies for growing winter wheat. One such element may be the use of herbicides together with plant growth regulators. The obtained experimental data testify to the protective ability of the growth regulator Regoplant against the winter wheat plants, as evidenced by a decrease in the activity of malonic dialdehyde accumulation, changes in the activity of the enzymatic defense system, decrease the number of epidermis cells and an increase in total rhizosphere bacteria in case of Regoplant use together with Granstar Gold 75, w.g. compared with the experiment variants, where the herbicide was applied without a growth regulator. That is, the use of growth regulator in a mixture with herbicide to some extent eliminates the toxic effect of xenobiotics, which has a positive effect on the state of ecobiosis of winter wheat sowing.

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Cited by 7 publications

References 4 publications

Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 15-Soybean Lipoxygenases

Exploring Sponge-Derived Terpenoids for Their Potency and Selectivity against 12-Human, 15-Human, and 15-Soybean Lipoxygenases

Influence of Silicon-Containing Water ‘Ardvi’ on Wound Healing and Long-Term Delayed Onset Muscle Soreness

Influence of Biologically Active Substances on Key Indicators of the Conditions of Winter Wheat Ecocenosis

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