v-src oncogene-specific carboxy-terminal peptide is immunoprotective against Rous sarcoma growth in chickens with MHC class I allele B-F12

Hofmann, Andrea; Plachý, Jiřı́; Hunt, Lawrence; Kaufman, Jim; Hála, K

doi:10.1016/s0264-410x(03)00516-4

Cited by 35 publications

(30 citation statements)

References 25 publications

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“…With smaller viruses, this chance becomes far greater. This has best been illustrated with Rous sarcoma virus (Kaufman, 2000;Hofmann et al, 2003), which only encodes four genes. Rous sarcoma virus is a transforming retrovirus that causes tumours, which progress and are fatal for some lines of chickens but are resolved in others.…”

Section: The Chicken's Contribution To Immunology As a Wholementioning

confidence: 99%

The long view: a bright past, a brighter future? Forty years of chicken immunology pre- and post-genome

Kaiser

2012

Avian Pathology

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Section: The Chicken's Contribution To Immunology As a Wholementioning

confidence: 99%

The long view: a bright past, a brighter future? Forty years of chicken immunology pre- and post-genome

Kaiser

2012

Avian Pathology

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“…None of the few v-src peptides predicted to bind to cells of the susceptible haplotypes B4 and B15 actually did bind above background, whereas three of the v-src peptides predicted to bind B12 cells bound, one of them strongly (Table 3). We have reported that vaccination of B12 chickens with the strongly bound peptide confers protection to RSV (27).…”

Section: The Peptide Motifs Of the Dominantly Expressed Class I Molecmentioning

confidence: 99%

Peptide motifs of the single dominantly expressed class I molecule explain the striking MHC-determined response to Rous sarcoma virus in chickens

Wallny

Ávila

Hunt

et al. 2006

Proc. Natl. Acad. Sci. U.S.A.

Self Cite

167

243

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Compared with the MHC of typical mammals, the chicken MHC is smaller and simpler, with only two class I genes found in the B12 haplotype. We make five points to show that there is a singledominantly expressed class I molecule that can have a strong effect on MHC function. First, we find only one cDNA for two MHC haplotypes (B14 and B15) and cDNAs corresponding to two genes for the other six (B2, B4, B6, B12, B19, and B21). Second, we find, for the B4, B12, and B15 haplotypes, that one cDNA is at least 10-fold more abundant than the other. Third, we use 2D gel electrophoresis of class I molecules from pulse-labeled cells to show that there is only one heavy chain spot for the B4 and B15 haplotypes, and one major spot for the B12 haplotype. Fourth, we determine the peptide motifs for B4, B12, and B15 cells in detail, including pool sequences and individual peptides, and show that the motifs are consistent with the peptides binding to models of the class I molecule encoded by the abundant cDNA. Finally, having shown for three haplotypes that there is a single dominantly expressed class I molecule at the level of RNA, protein, and antigenic peptide, we show that the motifs can explain the striking MHC-determined resistance and susceptibility to Rous sarcoma virus. These results are consistent with the concept of a ''minimal essential MHC'' for chickens, in strong contrast to typical mammals.antigen presentation ͉ avian ͉ essential ͉ evolution ͉ minimal

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“…MHC class II genes have been isolated from numerous fish species such as sea bass (Dicentrarchus labrax) [19], striped sea bass (Morone saxatilis) [126], red sea bream (Chrysophrys major) [127], various cichlids [128], salmonids [129e131] and different cyprinids [21,132e136]. MHC II genes in teleosts are also polymorphic and various studies have tried to establish the association of the MHC diversity [136,137] or differential gene expression [138e142] with disease resistance to viruses and bacteria, as such associations were identified in humans [143] and chickens [144].…”

Section: Recombination-activating Genesmentioning

confidence: 99%

Cell markers and determinants in fish immunology

Randelli

Buonocore

Scapigliati

2008

Fish & Shellfish Immunology

102

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Despite the impressive increase in the cloning and expression of genes encoding fish immunoregulatory molecules, the knowledge on "in vivo" and "in vitro" functional immunology of the corresponding peptide products is still at an initial stage. This is partly due to the lacking of specific markers for immunoregulatory peptides, that represent an indispensible tool to dissect immune reactions and to trace the fate of cellular events downstream of the activation. In this review we summarise the available information on functional immune activities of some teleost species and discuss the obtained data in an evolutionary and applied context.

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v-src oncogene-specific carboxy-terminal peptide is immunoprotective against Rous sarcoma growth in chickens with MHC class I allele B-F12

Cited by 35 publications

References 25 publications

The long view: a bright past, a brighter future? Forty years of chicken immunology pre- and post-genome

The long view: a bright past, a brighter future? Forty years of chicken immunology pre- and post-genome

Peptide motifs of the single dominantly expressed class I molecule explain the striking MHC-determined response to Rous sarcoma virus in chickens

Cell markers and determinants in fish immunology

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