UV Spectrophotometric Method Development and Validation of Fimasartan Drug and Its Tablet Formulation

Agrawal, Kaushik S; Gandhi, Lokesh R; Bhajipale, Nitin S

doi:10.22270/ajprd.v7i5.576

Cited by 4 publications

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…UV-Visible Spectroscopic has been developed for determination of Fimasartan in bulk and pharmaceutical dosage form. ( Agrawal et al,2019). The study of how chemical substance molecules, ions, and atoms absorb electromagnetic radiation at specific and limited wavelength ranges is known as absorption spectroscopy ( Kasture et al,2007).…”

Section: Introductionmentioning

confidence: 99%

Analytical Method Development and Validation of Fimasartan by Using Uv-Visible Spectrophotometric Method

Bhosale,

Sanap,

Patil

et al. 2023

ECB

View full text Add to dashboard Cite

For the determination of Fimasartan in pharmaceutical dosage forms, a straightforward, focused, accurate, and precise UV spectrophotometric approach was created and validated. The correlation was 0.9991, and the linearity was concentration range of 3-18 µg/ml. It was discovered that the regression equation was Y=0.0429x + 0.0034. Linearity, accuracy, precision, the limit of detection, the limit of quantitation, and the robustness of the method were all validated. The LOD and LOQ for estimation of Fimasartan were found to be 0.047 µg/ml and 0.144 µg/ml, respectively. Recovery of Fimasartan was found to be in the range of 98.37-100.92 %. The challenges of this research work of UV method development for Fimasartan include the need for precise and accurate measurement of the drug's concentration and the potential interference from impurities or other substances in the sample. The contributions made in the research work of UV method development for Fimasartan include the establishment of a reliable and efficient method for determining the drug's concentration in various samples, which can aid in its formulation, quality control and pharmacokinetic studies. Additionally, this method can contribute to the development of new drug delivery systems and dosage forms for Fimasartan. The proposed method for quantifying Fimasartan in pharmaceutical dosage form was effectively used.

show abstract

Section: Introductionmentioning

confidence: 99%

Analytical Method Development and Validation of Fimasartan by Using Uv-Visible Spectrophotometric Method

Bhosale,

Sanap,

Patil

et al. 2023

ECB

View full text Add to dashboard Cite

show abstract

Analytical method development and validation for simultaneous estimation of Fimasartan Potassium Trihydrate and Cilnidipine in synthetic mixture by HPLC for the treatment of hypertension stage-II

Sojitra

Chotaliya

2021

Futur J Pharm Sci

View full text Add to dashboard Cite

Background A specific, accurate, precise, robust, and cost-effective HPLC method was developed and validated for quantitative analysis of Fimasartan Potassium Trihydrate and Cilnidipine in fixed-dose combination. The isocratic elution was accomplished by Symmetry C18 column (150 mm × 4.6 mm, 5 µm) at 25 °C. Mobile phase composition is Methanol: Acetonitrile: Potassium Dihydrogen Phosphate buffer (pH 3) (60:05:35%v/v/v) at a flow rate of 1.0 mL/min, injection volume 20 µL with DAD detection at 240 nm. Result Fimasartan Potassium Trihydrate and Cilnidipine were eluted with retention time 2.65 min and 5.51 min respectively. This method was validated as per ICH guideline (Q2 R1). The calibration plots were over the concentration range of 15–90 μg/mL and 2.5–15 μg/mL for Fimasartan Potassium Trihydrate and Cilnidipine with correlation coefficient 0.9992 and 0.9989 respectively. Accuracy was obtained between 99.51–101.65% and 100.06–101.20% for Fimasartan Potassium Trihydrate and Cilnidipine respectively. LOD were found to be 0.97 μg/mL and 0.57 μg/mL and LOQ were found to be 2.95 μg/mL and 1.75 μg/mL for Fimasartan Potassium Trihydrate and Cilnidipine respectively. Conclusion The results showed that the developed method is reliable for the routine analysis for simultaneous determination of Fimasartan Potassium Trihydrate and Cilnidipine.

show abstract

Spectroscopic and Chromatographic Estimation of Some Sartans and their Combinations with Thiazide Diuretics: A Review

Baviskar,

Kachave

2023

CPA

View full text Add to dashboard Cite

Sartans are often used as antihypertensives. They are also available in combination with thiazide diuretics for the management of hypertension. Analytical method development is a crucial part of successful drug development and characterization. Bioanalytical studies are of paramount importance while establishing pharmacokinetic and toxicokinetic data while forced degradation studies are important to elucidate degradation pathways and to establish stability of the drugs. Different methods have been developed for the analysis of sartans and their combination with thiazide diuretics. We thought it imperative to summarize them so the data could be useful for analysis of newer sartans. The review describes various methods for analysis of some frequently employed sartans as well as the latest sartans and their combination with thiazide diuretics. The article also focuses on their analysis of biological fluids. Forced degradation studies have also been covered in the article. Article is divided into three sections. First section covers introduction, second section focuses on different methods developed, including bioanalytical methods, while third section presents forced degradation studies carried out on the drugs. Important parameters of the analytical methods developed have been summarized in tabular form.

show abstract

UV Spectrophotometric Method Development and Validation of Fimasartan Drug and Its Tablet Formulation

Cited by 4 publications

References 0 publications

Analytical Method Development and Validation of Fimasartan by Using Uv-Visible Spectrophotometric Method

Analytical Method Development and Validation of Fimasartan by Using Uv-Visible Spectrophotometric Method

Analytical method development and validation for simultaneous estimation of Fimasartan Potassium Trihydrate and Cilnidipine in synthetic mixture by HPLC for the treatment of hypertension stage-II

Spectroscopic and Chromatographic Estimation of Some Sartans and their Combinations with Thiazide Diuretics: A Review

Contact Info

Product

Resources

About