Background A specific, accurate, precise, robust, and cost-effective HPLC method was developed and validated for quantitative analysis of Fimasartan Potassium Trihydrate and Cilnidipine in fixed-dose combination. The isocratic elution was accomplished by Symmetry C18 column (150 mm × 4.6 mm, 5 µm) at 25 °C. Mobile phase composition is Methanol: Acetonitrile: Potassium Dihydrogen Phosphate buffer (pH 3) (60:05:35%v/v/v) at a flow rate of 1.0 mL/min, injection volume 20 µL with DAD detection at 240 nm. Result Fimasartan Potassium Trihydrate and Cilnidipine were eluted with retention time 2.65 min and 5.51 min respectively. This method was validated as per ICH guideline (Q2 R1). The calibration plots were over the concentration range of 15–90 μg/mL and 2.5–15 μg/mL for Fimasartan Potassium Trihydrate and Cilnidipine with correlation coefficient 0.9992 and 0.9989 respectively. Accuracy was obtained between 99.51–101.65% and 100.06–101.20% for Fimasartan Potassium Trihydrate and Cilnidipine respectively. LOD were found to be 0.97 μg/mL and 0.57 μg/mL and LOQ were found to be 2.95 μg/mL and 1.75 μg/mL for Fimasartan Potassium Trihydrate and Cilnidipine respectively. Conclusion The results showed that the developed method is reliable for the routine analysis for simultaneous determination of Fimasartan Potassium Trihydrate and Cilnidipine.
Nutraceuticals, which are defined as any food or component of food that has health benefits, such as the ability to prevent or treat disease, have become essential for consumers in both developed and developing nations. Functional elements like vitamins, minerals, and other nutrients are becoming more important due to the changing lifestyle. This category now includes things like probiotics, amino acids, and fatty acids, among others. In light of the fact that these items are intended for human consumption, regulatory bodies worldwide are concentrating on the Product Quality and Safety. This paper looks into the nutraceutical registration processes in different countries. The India have developed the Food for special dietary use registration process whereas the USA have put into place Dietary supplement registration process and the Japan have developed registration process for Foods for specified dietary use (FOSHU) whereas the China have developed registration process for Health foods. It also includes the marketed formulation of nutraceuticals. The aim of this paper is to compare the regulation processes between the different countries.
The WHO has declared the ongoing outbreak as a global public health emergency. Severe acute respiratory syndrome (SARS COV-II), the etiologic agent of COVID-19 has spread globally in a few months. It is a pandemic, surface to surface communicable disease. This review enlightens the preventive measures such as salt (sodium chloride) water as a selection of surface disinfectant. The application of saltwater is a sustainable and green concept and has several advantages including cost-effectiveness, ease of application, effective disinfection, on-the-spot production, safe for human beings and the environment. As compared to other chemical-based disinfectants and sanitizers, it is better to use on-hand techniques to clean vegetables and fruits, wooden surfaces, toys, and glasses with the most easily available, most economical, and non-toxic material of every house’s kitchen: A Common Salt. A simple saltwater solution containing approx 0.9-1.2% solution can be the cheapest, easiest, quickest, and safest way to clean different kinds of household surfaces to combat this pandemic situation.
Titanium Dioxide (TiO2) is widely used in food products and can be found in sauces, icings, and chewing gums as well as in personal care products such as pharmaceutical tablets and toothpaste. Tio2 particle added as a whitening agent to confectionary products, that is, chewing gum, candies, chocolate, and snacks. Titanium dioxide is found naturally in various crystal phases. It exists in different crystal structures. anatase, rutile, and brookite, or a mixture of these. The major routes of TiO2 NP exposure that have toxicological relevance in humans are inhalation, dermal, and oral exposure. for characterization of particle size, size distribution, crystallinity, and concentration of Tio2 particles were first extracted using an acid digestion method from food and separation, various analytical methods were applied. The present study focus on the analyzes qualitative and quantitative trace element by using some analytical methods. TiO2 levels of investigated foods were determined by UV Spectroscopy, Inductively coupled plasma optical emission spectroscopy (ICP-OES), X-ray photoelectron spectroscopy, UV-Visible diffuse reflectance, Raman spectroscopy, Electron microscopy, X-ray diffraction (XRD), Gas volumetry, Laser diffraction, Laser droppler electrophorosis, FT-Raman, Spectroscopic analysis.
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