The aim of the present study was to develop and validate a simple, rapid and reproducible gradient high performance reverse phase liquid chromatography method for the estimation of Teneligliptin and Metformin in bulk drug sample and pharmaceutical dosage forms u sing Cosmosil (C18, 250X4.6mm, 5μm) column with mobile phase composition of methanol and water (pH 3.5) 50:50 v/v. Flow rate of 0.7ml/min and uv detection at 242nm was maintain during the entire study. The retention time for Metformin and Teneligliptin was found to be 2.45 min and 6.21 min respectively. Linearity was observed over concentration range of 2-10μg/ml and 50-250 μg/ml for Teneligliptin and Metformin respectively. The accuracy of the proposed method was determined by recovery studies and found to be 98-101%. The proposed method was validated and results conformed to ICH parameters.
Buccal bioadhesive films, releasing topical drugs in the oral cavity at a slow and predetermined rate, provide distinct advantages over traditional dosage forms for treatment of many diseases. The mucosa of the buccal cavity is the most easily accessible transmucosal site. This fast dissolving drug delivery system (FDDS) is suited for the drugs which undergo high first pass metabolism and is used for improving bioavailability with reducing dosing frequency to mouth plasma peak levels, which in turn minimize adverse/side effects and also make it cost effective This article aims to review the recent Designs of buccal patches and their developments in the buccal adhesive drug delivery systems, & Buccal drug delivery is a promising area for continued research with the aim of systemic delivery of orally inefficient drugs as well as a feasible and attractive alternative for non-invasive delivery of potent peptide and protein drug molecules.
A novel, safe and sensitive method of Spectrophotometric estimation in UV - region has been developed for the assay of Fimasartan in its tablet formulation. The present study was undertaken to develop and validate a simple, accurate, precise, reproducible and cost effective UV spectrophotometric method for the estimation of Fimasartan bulk and pharmaceutical formulation. The method have been developed and validated for the assay of Fimasartan using Methanol as diluent. Absorption maximum (λmax) of the drug was found to be 240nm. The quantitative determination of the drug was carried out at 240nm. The method was shown linear in the mentioned concentrations having correlation coefficient R2 of 0.999. The recovery values for Fimasartan ranged from 98.74% to 99.23%.The Percent Relative Standard Deviation of interday and intraday was 0.85% and 0.75% respectively. All the parameters of the analysis were chosen according to the International Conference on Harmonisation guideline and validated statistically using Relative Standard Deviation and Percent Relative Standard Deviation. Hence, proposed method was precise, accurate and cost effective. This method could be applicable for quantitative determination of the bulk drug as well as dosage formulation. KEY WORDS:
A specific, accurate, precise and reproducible RP-HPLC method development validation for simultaneous estimation of cilnidipine and telmisartan in combined pharmaceutical dosage form. The proposed HPLC method utilizes Youglin C18 column (250 mm x 4.6 mm) 5 µm particle sizes and mobile phase consisting of Acetonitrile: 0.05% ortho phosphoric acid (60: 40) at a flow rate of 0.7 ml/min with UV detection 236 nm. The retention time of cilnidipine and telmisartan were found to be 4.650 min and 8.050 min respectively. The method was validated in terms of accuracy, precision, Linearity and robustness and was successfully applied for the determination of investigated drugs in combined dosage form.
Some drugs give poor absorption because of a narrow absorption window in the gastrointestinal tract (GIT). To improve the absorption of such drugs in GIT, gastro retentive drug delivery techniques play a vital role. Lamivudine is an antiviral medicine. The floating gastroretentive microspheres were prepared to attain an extended therapeutic action of Lamivudine. Floating microspheres were formulated to prolong the gastric retention and enhancement of bioavailability of the drug candidate. The floating microspheres were formulated using guar gum and xanthan gum as natural polymers. The proposed floating system was evaluated by preliminary evaluation parameters, micrometric investigation as well as Particle size investigation, Percentage yield of microspheres, Drug entrapment efficiency, In-vitro drug release studies, and their kinetics. The formulated microsphere is evaluated in the form of its stable nature. The formulated microsphere was found to be smooth, spherical, and slightly aggregated containing guar gum whereas xanthan gum containing microsphere was found porous, irregular, grossly, and discrete globular. Formulated microsphere gives a good percentage of drug entrapment and practical yields. The floating microsphere prolonged the drug release by up to 12 hrs. The IR spectroscopy of the prepared formulation was shown that the chemical structure of the Lamivudine was unchanged. The prepared lamivudine microspheres presented gastro retentive and extended-release properties. Keywords: Lamivudine; Microspheres; Narrow absorption window; Floating system
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