UV-photodegradation of desipramine: Impact of concentration, pH and temperature on formation of products including their biodegradability and toxicity

Khaleel, Nareman Dahshan Henedaq; Olsson, Oliver; Kümmerer, Klaus

doi:10.1016/j.scitotenv.2016.05.095

Cited by 17 publications

(8 citation statements)

References 34 publications

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“…The highest degradation rate was observed at pH = 9, when desipramine is in its unprotonated form. This fact was attributed to higher photolability of free base than protonated forms (Khaleel et al 2016 ). The photodegradation rate of synthetic estrogen, ethinylestradiol (p K a = 10.5), was highest at pH = 11 (unprotonated molecules, highest susceptibility to radiation) (Ren et al 2016 ).…”

Section: Photodegradation Of Pharmaceuticalsmentioning

confidence: 99%

“… GC–MS None None (Rúa-Gómez and Püttmann 2013 ) Buffer–ACN UV HPLC–PDA None None (mild photodegradation) (Rao et al 2015 ) Water (various pH) + TiO 2 UV-A UPLC–MS–LIT–Orbitrap IC TOC analyzer Microtox ( V. fisheri ) Over 70 detected (4 identified) (Lambropoulou et al 2016 ) Water + H 2 O 2 254 nm UPLC–MS–LTQ–Orbitrap Microtox ( V. fisheri ) 11 identified (García-Galán et al 2016 ) Imipramine Water UV-A Spectroph. HPLC RBC lysis; 3 T3 Test; PBR322 DNA strand breaks None (Viola et al 2000 ) Water + H 2 O 2 , Fe (II), TiO 2 300–800 nm HPLC–MS GC–MS Microtox 9 identified (Calza et al 2008 ) Desipramine Water; WW 300–800 nm UHPLC–MS Microtox 10 identified (Gros et al 2015 ) Water–ACN ICH HPLC None None (photostable) (Thiyagarajan et al 2008 ) Water (various pH) Xenon; UV UPLC–MS–LTQ–Orbitrap CBT, MRT tests Computational toxicity prediction 18 identified (Khaleel et al 2016 ) Mianserin Water; SHW 300–800 nm HPLC–MS/MS Microtox Spirotox Thamnotoxkit 3 (2 identified) (Wawryniuk et al …”

Section: Photodegradation Studies On Psychotropic Drugsmentioning

confidence: 99%

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Studies on photodegradation process of psychotropic drugs: a review

Trawiński

Skibiński

2016

Environ Sci Pollut Res

106

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Consumption of psychotropic drugs is still increasing, especially in high-income countries. One of the most crucial consequences of this fact is significant release of them to the environment. Considerable amounts of atypical antipsychotics, benzodiazepines, antidepressants, and their metabolites were detected in river, lake, and sea water, as well as in tissues of aquatic organisms. Their ecotoxicity was proved by numerous studies. It should be noticed that interaction between psychotropic pharmaceuticals and radiation may lead to formation of potentially more toxic intermediates. On the other hand, photo-assisted wastewater treatment methods can be used as an efficient way to eliminate them from the environment. Many methods based on photolysis and photocatalysis were proposed and developed recently; nevertheless, the problem is still unsolved. However, according to recent studies, photocatalysis could be considered as the most promising and far more effective than regular photolysis. An overview on photolytic as well as homogenous and heterogeneous photocatalytic degradation methods with the use of various catalysts is presented. The photostability and phototoxicity of pharmaceuticals were also discussed. Various analytical methods were used for the photodegradation research, and this issue was also compared and summarized. Use of high-resolution multistage mass spectrometry (Q-TOF, ion trap, Orbitrap) was suggested. The combined techniques such as LC–MS, GC–MS, and LC–NMR, which enable qualitative and quantitative analyses in one run, proved to be the most valuable in this case. Assembling of MS/MS spectra libraries of drug molecules and their phototransformation products was identified as the future challenge.

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Section: Photodegradation Of Pharmaceuticalsmentioning

confidence: 99%

Section: Photodegradation Studies On Psychotropic Drugsmentioning

confidence: 99%

Studies on photodegradation process of psychotropic drugs: a review

Trawiński

Skibiński

2016

Environ Sci Pollut Res

106

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“…Em todos os cenários propostos houve melhor ajuste dos dados experimentais ao modelo de pseudo-primeira ordem, pois os valores de R² variaram de 89 a 99%, sendo portanto superiores aos do modelo de pseudo-ordem zero (Tabela 1). A indicação deste modelo concorda com diversos estudos preliminares empregando fotodegradação de fármacos em meio aquoso (STURINI et al, 2010;LI et al, 2011;KHALEEL et al, 2016).…”

Section: Cinética De Fotodegradação Em Solução Aquosa E Esgoto Empreg...unclassified

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Costa¹,

Gomes²,

Rodrigues³

et al. 2022

Collection: Applied Environmental and Sanitary Engineering 2

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Direitos para esta edição cedidos à Atena Editora pelos autores. Open access publication by Atena Editora Todo o conteúdo deste livro está licenciado sob uma Licença de Atribuição Creative Commons. Atribuição-Não-Comercial-NãoDerivativos 4.0 Internacional (CC BY-NC-ND 4.0). O conteúdo dos artigos e seus dados em sua forma, correção e confiabilidade são de responsabilidade exclusiva dos autores, inclusive não representam necessariamente a posição oficial da Atena Editora. Permitido o download da obra e o compartilhamento desde que sejam atribuídos créditos aos autores, mas sem a possibilidade de alterá-la de nenhuma forma ou utilizá-la para fins comerciais.Todos os manuscritos foram previamente submetidos à avaliação cega pelos pares, membros do Conselho Editorial desta Editora, tendo sido aprovados para a publicação com base em critérios de neutralidade e imparcialidade acadêmica.A Atena Editora é comprometida em garantir a integridade editorial em todas as etapas do processo de publicação, evitando plágio, dados ou resultados fraudulentos e impedindo que interesses financeiros comprometam os padrões éticos da publicação. Situações suspeitas de má conduta científica serão investigadas sob o mais alto padrão de rigor acadêmico e ético.

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“…Ich struktura chemiczna, właściwości lub potencjalna toksyczność najczęściej nie są znane i w związku z tym należy je oceniać. W optymistycznej wersji związki chemiczne w wyniku naświetlania tracą swoją aktywność biologiczną i nie stanowią zagrożenia dla organizmów, ale w wielu przypadkach mogą tworzyć równie toksyczne, a nawet bardziej toksyczne produkty, często posiadające także większy potencjał do bioakumulacji [22,44,47,48]. Zrozumiałe jest zatem, że analiza produktów powstających w procesach fotodegradacji zasługuje na uwagę, głównie ze względu na potencjalną toksyczność dla organizmów wodnych.…”

Section: Fototoksyczność Leków -Wyzwanie Dla Ekotoksykologii?unclassified

Fototoksyczność Leków Dla Organizmów Wodnych - Ważny Element W Ocenie Ryzyka Środowiskowego

Wawryniuk¹,

Nałęcz-Jawecki²

2018

pps

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Leki wprowadzane do ekosystemów wodnych ulegają przemianom, zarówno biotycznym, jak i abiotycznym. Jednym z najważniejszych procesów abiotycznych jest fotodegradacja, w wyniku której mogą powstać produkty o trudnych do przewidzenia właściwościach biologicznych. W ostatnich latach znacznie wzrosła liczba publikacji na temat potencjalnego ryzyka środowiskowego wynikającego z powszechnej obecności substancji czynnych leków w wodach powierzchniowych. Jednakże dane na temat obecności w wodzie i oddziaływania na organizmy wodne produktów fotorozkładu leków są wciąż ograniczone. W niniejszej pracy przeanalizowano 34 doniesienia naukowe opublikowane w latach 2007‑2017 dotyczące badania toksyczności fotoproduktów, a raczej mieszanin powstałych w wyniku naświetlania w sumie 59 substancji czynnych leków. Fototoksyczność omówiono w oparciu o wyniki badań przeprowadzonych na 7 wodnych organizmach testowych, będących przedstawicielami różnych grup taksonomicznych i wszystkich poziomów troficznych. Przedstawiono zastosowane metodyki, najważniejsze wyniki eksperymentów, a także zaproponowano główne kierunki przyszłych badań.

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UV-photodegradation of desipramine: Impact of concentration, pH and temperature on formation of products including their biodegradability and toxicity

Cited by 17 publications

References 34 publications

Studies on photodegradation process of psychotropic drugs: a review

Studies on photodegradation process of psychotropic drugs: a review

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Fototoksyczność Leków Dla Organizmów Wodnych - Ważny Element W Ocenie Ryzyka Środowiskowego

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