Utilization of nanoparticle technology in rheumatoid arthritis treatment

Dolati, Sanam; Sadreddini, Sanam; Rostamzadeh, Davoud; Ahmadi, Majid; Jadidi‐Niaragh, Farhad; Yousefi, Mehdi

doi:10.1016/j.biopha.2016.03.004

Cited by 140 publications

(95 citation statements)

References 103 publications

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“…For that purpose, a wide variety of nanocarriers have been tested and extensively reviewed in the literature, including polymeric NPs, liposomes, solid-lipid NPs and polymeric micelles [222,234]. Moreover, nanotechnology- based gene therapy has also been explored for the treatment of RA.…”

Section: The Potential Of Nanotechnology For Immunomodulation Of Amentioning

confidence: 99%

Modulating the immune system through nanotechnology

Dacoba

Ana

Torres

et al. 2017

Seminars in Immunology

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Nowadays, nanotechnology-based modulation of the immune system is presented as a cutting-edge strategy, which may lead to significant improvements in the treatment of severe diseases. In particular, efforts have been focused on the development of nanotechnology-based vaccines, which could be used for immunization or generation of tolerance. In this review, we highlight how different immune responses can be elicited by tuning nanosystems properties. In addition, we discuss specific formulation approaches designed for the development of anti-infectious and anti-autoimmune vaccines, as well as those intended to prevent the formation of antibodies against biologicals.

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Section: The Potential Of Nanotechnology For Immunomodulation Of Amentioning

confidence: 99%

Modulating the immune system through nanotechnology

Dacoba

Ana

Torres

et al. 2017

Seminars in Immunology

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“…Nanoparticles are spherically shaped particles [39]. The size, surface characteristics and morphology of nanoparticles possess essential role towards the biodistribution of nanoparticle for RA treatment [40].…”

Section: Nanoparticles For the Treatment Of Ramentioning

confidence: 99%

“…NSAIDs based delivery systems were widely reported for RA, which decrease pain (analgesia) associated with early stage of RA through its anti-inflammatory mechanisms without loss of articular function, additionally; it blocks COX-1 and COX-2 enzymes which play an essential role in the generation of prostaglandins. Drug containing nanoparticle systems were delivered therapeutically to inflamed synovium [43]. Metal oxide nanoparticles reveals various desired characteristics such as drug carriers with incredible higher surface area and huge pore sizes for drug encapsulation, intrinsic biodegradability characteristics due to its labile metal-ligand bonds, and versatile functionality for post synthetic grafting of drug molecules [44].…”

Section: Nanoparticles For the Treatment Of Ramentioning

confidence: 99%

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

Janakiraman

Krishnaswami

Rajendran

et al. 2018

Materials Today Communications

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A B S T R A C TRheumatoid arthritis (RA) is the most common complex multifactorial joint related autoimmune inflammatory disease with unknown etiology accomplished with increased cardiovascular risks. RA is characterized by the clinical findings of synovial inflammation, autoantibody production, and cartilage/bone destruction, cardiovascular, pulmonary and skeletal disorders. Pro-inflammatory cytokines such as IL-1, IL-6, IL-8, and IL-10 were responsible for the induction of inflammation in RA patients. Drawbacks such as poor efficacy, higher doses, frequent administration, low responsiveness, and higher cost and serious side effects were associated with the conventional dosage forms for RA treatment. Nanomedicines were recently gaining more interest towards the treatment of RA, and researchers were also focusing towards the development of various anti-inflammatory drug loaded nanoformulations with an aid to both actively/passively targeting the inflamed site to afford an effective treatment regimen for RA. Alterations in the surface area and nanoscale size of the nanoformulations elicit beneficial physical and chemical properties for better pharmacological activities. These drug loaded nanoformulations may enhances the solubility of poorly water soluble drugs, improves the bioavailability, affords targetability and may improve the therapeutic activity. In this regimen, the present review focus towards the novel nanoparticulate formulations (nanoparticles, nanoemulsions, solid lipid nanoparticles, nanomicelles, and nanocapsules) utilized for the treatment of RA. The recent advancements such as siRNA, peptide and targeted based nanoparticulate systems for RA treatment were also discussed. Special emphasis was provided regarding the pathophysiology, prevalence and symptoms towards the development of RA.

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“…Nanotechnology refers to design and fabrication of materials and systems on the nanometers scale (1–1000 nm). With paralleling advances in nanotechnology, chemistry, and biology, numerous NMs have emerged as versatile platforms for treating various human diseases ranging from cancer to inflammation, typically including liposomes, micelles, polymeric nanoparticles, and metallic nanoparticles . These NMs have shown advantages in solubilizing therapeutic drugs, improving penetration ability, extending retention time, and prolonging the blood circulation half‐life of the cargos .…”

Section: Targeting Nms Relieve the Att Of Ramentioning

confidence: 99%

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

Liu

Guo

Liang

2018

Biotechnology Journal

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Rheumatoid arthritis (RA) is one of the most popular chronic autoimmune diseases characterized with persistent synovial inflammation and bone destruction. Although considerable developments have been gained in clinical treatment of RA, the major drawback to RA therapy stems from the adaptive treatment tolerance (ATT) following the long-term drug use, which causes compromised efficacy, sustained drug dose increase, and severe adverse events. To address these challenges, it is of great significance to put forward innovative therapeutic approaches for RA treatment. Nowadays, developments of nanotechnology-based nanomedicines (NMs) for RA are in progress. Multifunctional NMs with targeted stimuli-responsive features have been one of the central concepts in designing more accessible formulations for efficient RA treatment. These NMs are able to postpone RA progression effectively, because of their delivery and on-demand release of medicaments at targeted sites in response to external or internal stimuli related to the RA pathophysiology without obvious adverse side-effects on the normal tissues. Therefore, NMs have gained interest from pre-clinical research scientists as well as clinical doctors worldwide. Herein, the authors highlight the recent attempts of targeted stimuli-responsive NMs for RA therapy in the last 5 years. The described progresses may pave the way to novel and highly effective RA NMs.

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Utilization of nanoparticle technology in rheumatoid arthritis treatment

Cited by 140 publications

References 103 publications

Modulating the immune system through nanotechnology

Modulating the immune system through nanotechnology

Novel nano therapeutic materials for the effective treatment of rheumatoid arthritis-recent insights

Move to Nano‐Arthrology: Targeted Stimuli‐Responsive Nanomedicines Combat Adaptive Treatment Tolerance (ATT) of Rheumatoid Arthritis

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