Modulating the immune system through nanotechnology

Dacoba, Tamara G.; Ana, Olivera; Torres, Dolores; Crecente‐Campo, José; Alonso, Marı́a José

doi:10.1016/j.smim.2017.09.007

Cited by 101 publications

(89 citation statements)

References 278 publications

(281 reference statements)

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“…Surface charge and the zeta (ζ)-potential of nanosystems drives interactions with proteins, tissues, or with various components of the tissue, thus affecting cellular biodistribution and uptake. Host cells such as macrophages with anionic nature thus attract positively charged nanosystems compared to uncharged and negatively charged ones [21].…”

Section: Mechanism Of Nanosystems As Antibacterial Drug Delivery Agentsmentioning

confidence: 99%

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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Based on the recent reports of World Health Organization, increased antibiotic resistance prevalence among bacteria represents the greatest challenge to human health. In addition, the poor solubility, stability, and side effects that lead to inefficiency of the current antibacterial therapy prompted the researchers to explore new innovative strategies to overcome such resilient microbes. Hence, novel antibiotic delivery systems are in high demand. Nanotechnology has attracted considerable interest due to their favored physicochemical properties, drug targeting efficiency, enhanced uptake, and biodistribution. The present review focuses on the recent applications of organic (liposomes, lipid-based nanoparticles, polymeric micelles, and polymeric nanoparticles), and inorganic (silver, silica, magnetic, zinc oxide (ZnO), cobalt, selenium, and cadmium) nanosystems in the domain of antibacterial delivery. We provide a concise description of the characteristics of each system that render it suitable as an antibacterial delivery agent. We also highlight the recent promising innovations used to overcome antibacterial resistance, including the use of lipid polymer nanoparticles, nonlamellar liquid crystalline nanoparticles, anti-microbial oligonucleotides, smart responsive materials, cationic peptides, and natural compounds. We further discuss the applications of antimicrobial photodynamic therapy, combination drug therapy, nano antibiotic strategy, and phage therapy, and their impact on evading antibacterial resistance. Finally, we report on the formulations that made their way towards clinical application.

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Section: Mechanism Of Nanosystems As Antibacterial Drug Delivery Agentsmentioning

confidence: 99%

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

et al. 2020

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“…Although, strictly speaking, an oral vaccine might not be considered as a precision medicine, as it does not apply to a specific population segment, the antigen delivery carriers are designed to target a specific cell population, which are the M cells of the Peyer's patches (Figure 10). [91] To induce an immune response, antigens have to overcome the enzymatic degradation along the GIT, cross the mucus layer that stretches over the mucosal surfaces, and penetrate the epithelium. Adequate delivery systems such as nano-and micro-sized carriers offer interesting possibilities in this regard ( Table 3).…”

Section: Proteins and Peptidesmentioning

confidence: 99%

Oral Delivery of Biologics for Precision Medicine

2019

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Precision medicine has led to the identification of new biological drugs and targets for personalized treatments. A limitation of biological drugs relies on their difficulties for overcoming biological barriers. However, recent developments on drug delivery are opening new avenues that may soon make feasible the oral administration of biologics. In article number 1901935, María José Alonso and co‐workers provide an overview of the current situation, future prospects, barriers to clinical translation, and identified opportunities for advancement in this field.

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“…[126][127][128] Nanoparticles (NPs) can be taken-up and cross presented by DCs. [126][127][128] Nanoparticles (NPs) can be taken-up and cross presented by DCs.…”

Section: Nanoparticles and Microparticlesmentioning

confidence: 99%

“…Many different delivery structures have been developed. [126][127][128] Nanoparticles (NPs) can be taken-up and cross presented by DCs. [129][130][131][132] Nanoparticles coated with autoimmune disease-relevant peptide bound to MHC II molecules, when given systemically, can expand pre-existing antigen-experienced Treg and/or induce differentiation of antigen-experienced Th1 cells into Treg cells.…”

Section: Nanoparticles and Microparticlesmentioning

confidence: 99%

Role of lymph node stroma and microenvironment in T cell tolerance

Saxena

Paluskievicz

et al. 2019

Immunological Reviews

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Lymph nodes (LNs) are at the cross roads of immunity and tolerance. These tissues are compartmentalized into specialized niche areas by lymph node stromal cells (LN SCs). LN SCs shape the LN microenvironment and guide immunological cells into different zones through establishment of a CCL19 and CCL21 gradient. Following local immunological cues, LN SCs modulate activity to support immune cell priming, activation, and fate. This review will present our current understanding of LN SC subsets roles in regulating T cell tolerance. Three major types of LN SC subsets, namely fibroblastic reticular cells, lymphatic endothelial cells, and blood endothelial cells, are discussed. These subsets serve as scaffolds to support and regulate T cell homeostasis. They contribute to tolerance by presenting peripheral tissue antigens to both CD4 and CD8 T cells. The role of LN SCs in regulating T cell migration and tolerance induction is discussed. Looking forward, recent advances in bioengineered materials and approaches to leverage LN SCs to induce T cell tolerance are highlighted, as are current clinical practices that allow for manipulation of the LN microenvironment to induce tolerance. Increased understanding of LN architecture, how different LN SCs integrate immunological cues and shape immune responses, and approaches to induce T cell tolerance will help further combat autoimmune diseases and graft rejection.

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Modulating the immune system through nanotechnology

Cited by 101 publications

References 278 publications

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Nanomedicine Fight against Antibacterial Resistance: An Overview of the Recent Pharmaceutical Innovations

Oral Delivery of Biologics for Precision Medicine

Role of lymph node stroma and microenvironment in T cell tolerance

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