Utility of oxidation–reduction reaction for the determination of ranitidine hydrochloride in pure form, in dosage forms and in the presence of its oxidative degradates

Amin, Alaa S.; Ahmed, Ibrahim S.; Dessouki, H.A.; Gouda, Eslam A

doi:10.1016/s1386-1425(02)00226-3

Cited by 32 publications

(27 citation statements)

References 21 publications

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“…Potassium bromate, being a mild oxidant, was used in this experiment to oxidize the ascorbic acid; however, it was unable to oxidize the drug (RAN). This gave an important advantage to the proposed method over the method reported by Amin et al (12,13) who did not investigate that interference.…”

Section: Validation Of the Methodsmentioning

confidence: 88%

“…-In all cases, Beer's law plots (n = 5) were linear with good correlation coefficients (0.9988-0.9998) in the general concentration ranges of 8-30, 6-22, 6-25, and 4-20 mg mL -1 for CIM, FAM, NIZ, and RAN, respectively (Table I). Amin et al (12,13) reported the range of 0.1-2.6 mg mL -1 . The limits of detec- tion (LOD) and limits of quantitation (LOQ) were determined (24) using the formula: LOD or LOQ = kSD a /b, where k = 3.3 for LOD and 10 for LOQ, SD a is the standard deviation of the intercept, and b is the slope.…”

Section: Validation Of the Methodsmentioning

confidence: 99%

“…These methods include titrimetry (2), electrochemical methods (3), TLC (4), HPLC (5,6), capillary electrophoresis (7), immunoassay (8), fluorimetry (9,10), and spectrophotometry (11)(12)(13)(14)(15)(16)(17).…”

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confidence: 99%

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A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol

Darwish¹,

Hussein²,

Mahmoud³

et al. 2008

Acta Pharmaceutica

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A simple, accurate and sensitive spectrophotometric method for determination of H 2 -receptor antagonists: cimetidine (CIM), famotidine (FAM), nizatidine (NIZ), and ranitidine hydrochloride (RAN) has been fully developed and validated. The method was based on the reaction of these drugs with NBS and subsequent measurement of the excess N-bromosuccinimide by its reaction with p-aminophenol to give a violet colored product (l max at 552 nm). Decrease in the absorption intensity (DA) of the colored product, due to the presence of the drug, was correlated with its concentration in the sample solution. Different variables affecting the reaction were carefully studied and optimized. Under optimal conditions, linear relationships with good correlation coefficients (0.9988-0.9998) were found between DA values and the corresponding concentrations of the drugs in a concentration range of 8-30, 6-22, 6-25, and 4-20 mg mL -1 for CIM, FAM, NIZ, and RAN, respectively. Limits of detection were 1.22, 1.01, 1.08, and 0.74 mg mL -1 for CIM, FAM, NIZ, and RAN, respectively. The method was validated in terms of accuracy, precision, ruggedness, and robustness; the results were satisfactory. The proposed method was successfully applied to the analysis of the above mentioned drugs in bulk substance and in pharmaceutical dosage forms; percent recoveries ranged from 98.5 ± 0.9 to 102.4 ± 0.8% without interference from the common excipients. The results obtained by the proposed method were comparable with those obtained by the official methods.

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Section: Validation Of the Methodsmentioning

confidence: 88%

Section: Validation Of the Methodsmentioning

confidence: 99%

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A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol

Darwish¹,

Hussein²,

Mahmoud³

et al. 2008

Acta Pharmaceutica

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“…: NBS, being the most versatile, has been used for the spectrophotometric determination of different drugs (26)(27)(28)(29) . These methods involves two stages oxidation of the drug by NBS and the estimation of unconsumed NBS with Celestine blue (CB).…”

Section: Cefprozilmentioning

confidence: 99%

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

2010

Egypt. J. Chem.

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WO SIMPLE, accurate spectrophotometric and potentiometric m methods were developed for the determination of cefprozil, dropropizine and tizanidine hydrochloride in their pharmaceutical preparations. The spectrophotometric method is based on the selective oxidation of cefprozil or tizanidine with N-bromosuccinimide in an alkaline medium to give an intense yellow product with a maximum absorption at 396 or 384 nm, respectively. The reaction conditions were studied and optimized. The reaction obeyed Beer's law over the concentration range 5-40 and 10-80 g ml -1 for cefprozil and tizanidine hydrochloride, respectively. The potentiometric method involves the direct titration of cefprozil and dropropizine with Nbromosuccinimide in sulphuric acid medium and the end point is determined potentiometrically using platinum electrode. Cefprozil and dropropizine can be determined quantitatively in the concentration range of 0.13-1.30 and 0.118-1.180 mg with recovery values of 98.46-100.77 and 99.58-100.85% and relative standard deviations 0.39-0.54 and 0.52-0.87% for cefprozil and dropropizine, respectively. The proposed methods are applied for the determination of these drugs in pure forms and in pharmaceutical preparations.

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“…N-Bromosuccinimide, due to its strong oxidation properties, has been extensively employed as a reagent in the analytical investigations of many organic compounds: phenothiazine derivatives, 12 nitrofurazone, 13 ranitidine, 14 verapamil 15 and prazosin hydrochlorides, 16 tertiary amines and ammonium salts 17 and some catecholamine derivatives. 18 The reaction of oxidation of olanzapine with NBS showed that the investigated drug is easily oxidized with NBS in acidic medium, giving the purple product of oxidation (λ = 532 nm).…”

Section: Introductionmentioning

confidence: 99%

Spectrophotometric Determination of Olanzapine by Its Oxidation with N-Bromosuccinimide and Cerium(IV)sulfate

Krebs

Starczewska

Puzanowska-Tarasiewicz

et al. 2006

ANAL. SCI.

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Three simple spectrophotometric methods have been described for the assay of olanzapine in its pure and pharmaceutical formulations. The direct method (A) is based on the drug oxidation with excess of N-bromosuccinimide in acidic medium and the two indirect methods (B and C) are based on the oxidation of the drug with excess of Nbromosuccinimide and cerium(IV)sulfate, followed by the reaction of the unconsumed oxidants with celestine blue. The calibration graphs were linear over the range 10 -120 μg mL -1 (method A), 0.5 -6.0 μg mL -1 (method B) and 0.6 -3.0 μg mL -1 (method C). After validation, the proposed methods were successfully applied to assay of olanzapine in its commercial tablets with mean percentage recoveries of 101.23 ± 0.10, 96 ± 0.10 and 94 ± 0.04%. The mechanism of olanzapine oxidation with N-bromosuccinimide was also proposed.

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Utility of oxidation–reduction reaction for the determination of ranitidine hydrochloride in pure form, in dosage forms and in the presence of its oxidative degradates

Cited by 32 publications

References 21 publications

A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol

A sensitive spectrophotometric method for the determination of H2-receptor antagonists by means of N-bromosuccinimide and p-aminophenol

Spectrophotometric and Potentiometric Methods for the Determination of Cefprozil, Dropropizine and Tizanidine Hydrochloride in Pharmaceutical Preparations

Spectrophotometric Determination of Olanzapine by Its Oxidation with N-Bromosuccinimide and Cerium(IV)sulfate

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