Utility of Non-invasive Cardiac Imaging Assessment in Coronavirus Disease 2019

Hothi, Sandeep S; Jiang, Jin; Steeds, Richard P; Moody, William E.

doi:10.3389/fcvm.2021.663864

Cited by 10 publications

(11 citation statements)

References 66 publications

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“…Therefore, it is necessary to study the long-term consequences on the cardiac function of patients infected with SARS-CoV-2 [ 6 , 7 ]. Transthoracic echocardiography (TTE) remains an important imaging modality used for assessing cardiac function, which can provide relevant information that may impact clinical management for those infected with SARS-CoV-2 [ 8 ]. Left ventricular global longitudinal strain (LVGLS), measured by speckle tracking echocardiography (STE), provides a way to quantify myocardial deformation independent of left ventricular ejection fraction (LVEF) [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Bhatti¹,

Sanchez²,

Dhungana³

et al. 2022

Cureus

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Coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2, is an ongoing pandemic that has affected millions globally. Many infected patients have been noted to have cardiovascular damage. Prior to the development of clinical symptoms, the use of transthoracic echocardiography, specifically with measurements of left ventricular global longitudinal strain (LVGLS), may provide an additional prognostic marker for patients infected with COVID-19. We sought to determine whether patients with COVID-19 and reduced LVGLS have an increased risk for mortality. The mean LVGLS was determined to be significantly lower in the non-survivors compared to the survivors (−11.6 ± 1.8 vs −15.4 ± 0.74, p<0.05). It should be noted, however, that even those that survived were found to have reduced LVGLS (<−18.5%). A multivariate logistic regression analysis was also performed that demonstrated a relationship between reduced LVGLS and an increased risk for mortality. Overall, our data indicate that COVID-19 patients may have subclinical left ventricular dysfunction, and that critically ill patients may have a greater decline in cardiac dysfunction.

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Section: Introductionmentioning

confidence: 99%

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Bhatti¹,

Sanchez²,

Dhungana³

et al. 2022

Cureus

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“…In another study, 84% of positive CMR patients were symptomatic, compared to only half of the patients with negative CMR (28) . In addition, although LV diastolic dysfunction was more in post-COVID-19 patients, previous studies (12,29) showed concomitant RV diastolic dysfunction that could be explained by ventricular interdependence (30) . Previous studies on mild COVID-19 cases showed that RV diameters and systolic function were usually within the normal range despite evidence of myocardial injury (16)(17) .…”

Section: Discussionmentioning

confidence: 84%

Right Ventricular Diastolic Dysfunction in Young Adults after Mild COVID-19

Hafez¹,

Bastawy²,

Kamel³

2022

The Egyptian Journal of Hospital Medicine

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Background: Myocardial injury is neither limited to the acute Coronavirus disease 2019 nor moderate-to-severe cases.Objectives: This study aimed to evaluate the relationship between right ventricular diastolic dysfunction and post-Coronavirus disease 2019 cardiovascular sequelae in young adults with mild disease. Patients and Methods: This study recruited 150 young adults (between 18 and 30 years) who were classified into three equal groups: Group A included 50 patients who sustained cardiac symptoms 12 to 14 weeks following mild Coronavirus disease 2019. Group B included 50 patients who did not show cardiac symptoms 12 to 14 weeks following mild Coronavirus disease 2019. Group C included 50 gender-matched healthy subjects of similar ages without previous Coronavirus disease 2019. Each subject underwent a detailed transthoracic echocardiographic study to detect right ventricular diastolic dysfunction by measuring the tricuspid valve E/A ratio, tricuspid deceleration time, tricuspid E/e' ratio and tricuspid e'/a' ratio. Results: Right ventricular diastolic dysfunction was higher in group A (80% versus 30% versus 0%, p < 0.001).Tricuspid valve e'/a' was lower in group A (0.86 ± 0.2 versus 1.08 ± 0.2 versus 1.44 ± 0.28, p < 0.001) while tricuspid valve E/ e' was higher (6.7 ± 1.1 versus 3.25 ± 3 versus 3.04 ± 0.36, p < 0.001). Post-Coronavirus disease 2019 patients with right ventricular diastolic dysfunction had a higher right ventricular basal diameter, higher right ventricular systolic pressure, lower right ventricular tricuspid annular plane systolic excursion, and lower fractional area change. Conclusions: After recovery from mild Coronavirus disease 2019, some of young adults had right ventricular diastolic dysfunction, which was more prevalent in those with post-Coronavirus disease 2019 cardiac symptoms.

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“…Since the physicians have obtained data about cardiac involvement during the COVID-19 acute phase, several studies with cardiac imaging have been carried out to determine different markers to guide the decision-making process and understand this disease's cardiovascular evolution. Echocardiography and cardiac magnetic resonance (CMR) were the most explored techniques [58,59]. The main findings of both imaging techniques are summarized in Figure 3.…”

Section: Cardiac Imaging Findingsmentioning

confidence: 99%

“…One of the main findings in echocardiographic studies is the right ventricle (RV) impairment. The pathophysiology of COVID-19 with an important incidence of ARDS can lead to the development of RV dysfunction due to the increased pulmonary microvascular resistance, accompanied by microvascular thrombi, high rate of PE, and even due to mechanical ventilation itself [58,59]. Manzur-Sandoval et al found a high frequency of echocardiographic signs of RV dysfunction (reduced fractional shortening, reduced tricuspid annular plane systolic excursion, and RV dilatation) in patients who required hospital admission.…”

Section: Echocardiographymentioning

confidence: 99%

Acute and Chronic Effects of COVID-19 on the Cardiovascular System

Arévalos

Ortega‐Paz

Rodríguez-Arias

et al. 2021

JCDD

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COVID-19 has shown significant morbidity with the involvement of multiple systems, including the cardiovascular system. Cardiovascular manifestations in the acute phase can include myocardial injury itself, myocardial infarction, venous thromboembolic events, myocarditis, Takotsubo syndrome, and different arrhythmic events. Myocardial injury defined by the rise of cardiac biomarkers in blood has been found in multiple studies with a prevalence of about 20%. Its presence is related to worse clinical outcomes and in-hospital mortality. The mechanisms of myocardial injury have been the subject of intense research but still need to be clarified. The characterization of the cardiac affectation with echocardiography and cardiac magnetic resonance has found mixed results in different studies, with a striking incidence of imaging criteria for myocarditis. Regarding post-acute and chronic follow-up results, the persistence of symptoms and imaging changes in recovered COVID-19 patients has raised concerns about the duration and the possible significance of these findings. Even though the knowledge about this disease has increased incredibly in the last year, many aspects are still unclear and warrant further research.

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Utility of Non-invasive Cardiac Imaging Assessment in Coronavirus Disease 2019

Cited by 10 publications

References 66 publications

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Right Ventricular Diastolic Dysfunction in Young Adults after Mild COVID-19

Acute and Chronic Effects of COVID-19 on the Cardiovascular System

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