Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Bhatti, Harneet; Sanchez, Andres Cordova; Dhungana, Rajat; Carvounis, Christos P.; Singh, Avneet

doi:10.7759/cureus.23986

Cited by 4 publications

(6 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…3 Few studies have investigated the prevalence of abnormal LV-GLS and its prognostic value in COVID-19 infection. [7][8][9][10] Janus et al showed similar results to our study with increased mortality observed with reduction in LV-GLS. 10 The study conducted by Baycan et al demonstrated similar results to ours with significant association between abnormal LV-GLS and in-hospital mortality.…”

Section: Discussionsupporting

confidence: 91%

Prevalence of abnormal left ventricular global longitudinal strain by speckle tracking echocardiography and its prognostic value in patients with COVID-19

Hegde,

Shnoda,

Alkhadra

et al. 2024

Open Heart

View full text Add to dashboard Cite

ImportanceAlthough cardiac injury is a known complication of COVID-19 infection, there is no established tool to predict cardiac involvement and in-hospital mortality in this patient population.ObjectiveTo assess if left ventricular global longitudinal strain (LV-GLS) can detect cardiac involvement and be used as a risk-stratifying parameter for hospitalised patients with COVID-19.Main outcomes and measuresIn-hospital mortality.ResultsWe found a statistically significant association between LV-GLS and in-hospital mortality (adjusted OR (aOR)=1.09; 95% CI 1.0 to 1.19, p=0.050). Furthermore, right ventricular fractional area change was significantly associated with in-hospital mortality (aOR=1.04; 95% CI 1.0 to 1.08, p=0.043). Troponin level had no statistically significant association with in-hospital mortality (aOR=3.43; 95% CI 0.78 to 15.03, p=0.101).Conclusion and relevanceLV-GLS can be a useful parameter for cardiovascular risk assessment in hospitalised patients with COVID-19 infection.

show abstract

Section: Discussionsupporting

confidence: 91%

Prevalence of abnormal left ventricular global longitudinal strain by speckle tracking echocardiography and its prognostic value in patients with COVID-19

Hegde,

Shnoda,

Alkhadra

et al. 2024

Open Heart

View full text Add to dashboard Cite

show abstract

“…on 90 COVID-19 hospitalized patients showed a significant decline in LV GLS in nonsurvivors as compared with survivors, whereas no significant alteration in LVEF was found, indicating that COVID-19 patients might have subclinical LV dysfunction, especially in those who were exposed to a more powerful cytokine storm and hence myocardial injury, which could result in more decline in cardiac function. [ 21 ]…”

Section: Discussionmentioning

confidence: 99%

Can Global Longitudinal Strain Assess Asymptomatic Subtle Left Ventricular Dysfunction in Recovered COVID-19 Patients?

Mansour,

Abdelhady,

Reheim

et al. 2023

Journal of Cardiovascular Echography

View full text Add to dashboard Cite

Background: Coronavirus disease 2019 (COVID-19) might be associated with cardiac injury as a part of multisystem affection in response to cytokine storms. However, left ventricular (LV) function appears preserved in most of the cases, whereas subtle LV dysfunction might happen in others. Hence, we tried to detect subtle LV dysfunction in patients with COVID-19 using global longitudinal strain (GLS). Patients and Methods: We performed a single-center observational study on 90 stable patients who were recently recovered from mild to moderate COVID-19 infections. A transthoracic echocardiographic examination was done for all patients, and GLS assessment was used as an indicator of LV function. Results: The population age ranged from 27 to 66 years, and the majority of patients were males (54, 73.3%). Besides, 46.7% of the included patients were smokers, 33.3% had hypertension, and 23.3% were diabetics. All the patients had normal LV internal dimensions and ejection fractions. However, 33.3% of them had subclinical LV dysfunction as expressed by reduced GLS. There was no statistically significant correlation between GLS and age, gender, or other risk factors, whereas troponin and C-reactive protein significantly correlated with GLS. Conclusions: Recovered patients from recent mild to moderate COVID-19 infections might show subtle LV dysfunction as manifested by reduced GLS.

show abstract

“…Longitudinal and circumferential changes diverge as myocardial disease progresses, which may contribute to the ability of strain to predict outcomes. Two-dimensional speckle tracking technology can identify myocardial dysfunction and subclinical myocardial injury ( 28 ), and studies have shown the potential value of ventricular strain assessment in COVID-19 patients ( 29 – 31 ). Our study found that SpO 2 , E/e' and LVGLS were the independent risk factors for mild patients progressing to moderate/severe group, and LVGLS played the most important part.…”

Section: Discussionmentioning

confidence: 99%

Sequence and directivity in cardiac muscle injury of COVID-19 patients: an observational study

Wang,

Chen,

Jin

et al. 2023

Front. Cardiovasc. Med.

View full text Add to dashboard Cite

ObjectiveTo compare cardiac function indicators between mild and moderate to severe COVID-19 patients and to try to identify the sequence and directivity in cardiac muscle injury of COVID-19 patients.MethodsFrom December 2022 to January 2023, all patients with laboratory-confirmed SARS-CoV-2 infection in Shanghai General Hospital Jiading Branch were enrolled. The clinical classification was stratified into mild, moderate, or severe groups. We collected the clinical and laboratory information, transthoracic echocardiographic and speckle-tracking echocardiographic parameters of patients and compared the differences among different groups.ResultsThe values of echocardiographic parameters in mild group were lower than that in moderate or severe group (P < 0.05) except LVEF. The values of LVEF of mild and moderate group were higher than severe group (P < 0.05). There were no significant differences between moderate and severe group. Positive correlations were observed between left ventricular global longitudinal strain (LVGLS) and myoglobin (r = 0.72), E/e' and age (r = 0.79), E/e' and BNP (r = 0.67). The multivariate analysis shows that SpO2 (OR = 0.360, P = 0.02), LVGLS (OR = 3.196, P = 0.003) and E/e' (OR = 1.307, P = 0.036) were the independent risk factors for mild cases progressing to moderate or severe. According to the receiver operating characteristic (ROC) curves, when all the COVID-19 patients was taken as the sample size, the area under the curve (AUC) of the LVGLS was the highest (AUC = 0.861). The AUC of the LVGLS was higher than LVGCS (AUC = 0.565, P < 0.001).ConclusionWhen mild COVID-19 progresses to moderate or severe, both systolic and diastolic functions of the heart are impaired. LVGLS was the independent risk factor for mild cases progressing to moderate or severe cases. Longitudinal changes may manifest earlier than circumferential changes as myocardial disease progresses in COVID-19.

show abstract

Left Ventricular Global Longitudinal Strain in Patients With COVID-19 Infection

Cited by 4 publications

References 20 publications

Prevalence of abnormal left ventricular global longitudinal strain by speckle tracking echocardiography and its prognostic value in patients with COVID-19

Prevalence of abnormal left ventricular global longitudinal strain by speckle tracking echocardiography and its prognostic value in patients with COVID-19

Can Global Longitudinal Strain Assess Asymptomatic Subtle Left Ventricular Dysfunction in Recovered COVID-19 Patients?

Sequence and directivity in cardiac muscle injury of COVID-19 patients: an observational study

Contact Info

Product

Resources

About