Utility of Extracted Colored Ion – Associate Complexes Formation Reaction for the Determination of Fexofenadine Hydrochloride in Pure Forms and in Dosage Forms

Amin, Alaa S.; Ahmed, Ibrahim S.; Mohamed, Hassan A.

doi:10.4172/2157-7048.1000101

Cited by 3 publications

(2 citation statements)

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“…The drug is official in BP [3] and USP [4], which describe HPLC methods for the assay of fexofenadine hydrochloride. Several analytical methods for the determination of fexofenadine hydrochloride in pharmaceutical formulations have been reported including high performance liquid chromatography [5][6][7][8], spectrophotometry [8][9][10][11][12], conductometry [13], extractive spectrophotometry with bromothymol blue, bromocresol green, bromocresol purple and bromophenol blue [13,14], spectrofluorometry [15], potentiometry [16] and capillary electrophoresis [17,18]. Fexofenadine hydrochloride has been determined in combination with other drugs using high performance liquid chromatography [19][20][21][22][23], high performance thin layer chromatography [24] and spectrophotometry [25][26][27] in combined dosage forms.…”

Section: Introductionmentioning

confidence: 99%

“…Therefore, ion-pair extractive spectrophotometry has received considerable attention for the quantitative determination of many pharmaceutical compounds [13,14,33,[53][54][55]. So far, there has been no ion-pair extractive spectrophotometry method reported for an estimation of fexofenadine hydrochloride and irbesartan with naphthol blue black.…”

Section: Introductionmentioning

confidence: 99%

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Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Ashour¹

2017

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A simple, accurate and sensitive method has been presented for the determination of fexofenadine hydrochloride (FEX) and irbesartan (IRB) in bulk and pharmaceutical preparations. The method is based on the reaction of the above cited drugs with naphthol blue black (NBB) dye in solutions containing Britton buffer to form ion-pair complexes extractable with chloroform and subsequently measured spectrophotometrically at 625 nm. All the reaction conditions for the proposed methods have been studied. The reactions were extremely rapid at room temperature and the absorbance values remained unchanged for at least 24 hrs. Beer's law was obeyed in the concentration ranges 2.7-53.8 and 10-244 µg mL -1 with detection limit of 0.013 and 0.75 µg mL -1 for FEX and IRB, respectively. The proposed methods were applied successfully for the determination of FEX and IRB in pharmaceutical formulations. Interferences of the other ingredients and excipients were not observed. The results obtained were compared statistically with those obtained by the official method and showed no significant differences regarding accuracy and precision.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Ashour¹

2017

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Analysis for commonly prescribed non-sedating antihistamines

El-Kommos

El-Gizawy

Atia

et al. 2015

Analytical Chemistry Research

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Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

et al. 2012

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The present study describes two simple, rapid, selective, and cost-effective spectrophotometric methods for the determination of an antiallergic drug, fexofenadine hydrochloride (FFH), in bulk drug, tablets, and in spiked human urine. The first method (method A) is based on the formation of yellow-colored ion-pair complex between FFH and alizarin red S (AZS) in acid medium which was extracted into dichloromethane, and the absorbance was measured at 440 nm. The second method (method B) is based on the breaking of the yellow FFH-AZS ion-pair complex in alkaline medium followed by the measurement of the violet-colored free dye at 590 nm. Under the optimized conditions, Beer's law is obeyed over the concentration ranges of 0.4-12.0 and 0.2-3.5 μg mL −1 FFH for method A and method B, respectively, and the corresponding molar absorptivity values are 3.80 × 10 4 and 1.61 × 10 5 L mol −1 cm −1 . The Sandell's sensitivity, detection, and quantification limits are also reported. The proposed methods were successfully applied to the determination of FFH in pure drug and commercial tablets. The accuracy and reliability of the proposed methods were further established by recovery studies via standard addition technique.

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Utility of Extracted Colored Ion – Associate Complexes Formation Reaction for the Determination of Fexofenadine Hydrochloride in Pure Forms and in Dosage Forms

Cited by 3 publications

References 28 publications

Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Analysis for commonly prescribed non-sedating antihistamines

Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

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