Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

Raghu, M.S.; Basavaiah, K.; Prashanth, Kudige N.; Vinay, K. B.

doi:10.5402/2012/648510

Cited by 3 publications

(2 citation statements)

References 23 publications

(24 reference statements)

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“…Antioxidant activity: Free radicals mostly generated Chromogenic agent: Alizarin red S has been widely used for validation of antidepressant drug Dothiepin Hydrochloride (DOTH) in drug formulations by development of ion-pair complex between DOTH and alizarin red S [43] . It is also used for validation of anti-allergic drug, fexofenadine hydrochloride by development of ion-pair complex between fexofenadine hydrochloride and alizarin red S [44] .…”

Section: Ethno-pharmacological Usesmentioning

confidence: 99%

Ethno-Medicinal and Therapeutic Applications of Natural Anthraquinones: Recent Trends and Advancements

Mohapatra¹,

Basak²

2023

IJPS

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Traditional and ethno-medicinal use of plants enforces a holistic approach towards human health by wittily utilizing the synergistic potency of the bioactive compounds. Quinones are unique molecules with several therapeutic properties that lead them as most vital compound in pharmaceutical system. They can easily undergo reduction reaction paving the path for many biological processing. This class of molecules helps in treatment of several chronic ailments. Many of the drugs in Ayurvedic formulations and/or modern medicinal sectors are having one or more types of quinone groups as a major bio-active compound. However these aforementioned properties of quinones make them unique and versatile. The biochemical knowledge of these compounds is necessary to understand their physiological and toxicological properties. Amongst all quinones found naturally, anthraquinones are one of its kinds due to wide spectrum utilization in several drug formulations. In this review a brief detail of six unique yet ethno-botanically and pharmacologically versatile quinone compounds are depicted with their natural resources, structural characterization and ethnopharmacological activities. The gathered information regarding the above mentioned bio-active compounds would be helpful in identification and isolation of these compounds from a wide range of natural sources with structural characterization and pharmacological potency. These data would be pivotal in their precise identification for further use in both Ayurvedic and modern drug formulation sectors thereby lessening the threat status of the frequently used rare, endangered and threatened plants.

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Section: Ethno-pharmacological Usesmentioning

confidence: 99%

Ethno-Medicinal and Therapeutic Applications of Natural Anthraquinones: Recent Trends and Advancements

Mohapatra¹,

Basak²

2023

IJPS

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“…ARS is applied as an acid-base indicator, 8 a red textile dye, 9 for staining in histology 10 and as a chromogenic agent for selective spectroscopic determination of some compounds. 11 For removing ARS from wastewaters, various kinds of adsorbents were used, such as activated carbon/γ-Fe 2 O 3 nano-composite, 12 modified nano-sized silica, 13 magnetic chitosan, 14 lantana camara, 15 coconut shell activated carbon, 16 activated clay modified by iron oxide, 17 Fe 3 O 4 /CeO 2 nanocomposite, 18 calcined [Mg/Al, Zn/Al and MgZn/Al]-LDH, 19 nanocrystalline Cu 0.5 Zn 0.5 Ce 3 O 5 , 20 activated carbon engrafted with Ag nanoparticles, 21 nano-Fe 3 O 4 and corn cover composite 22 and chitosan/ZnO nanorod composite. 23 The q e,max value values of these adsorbents are tabulated in Table 1.…”

Section: Introductionmentioning

confidence: 99%

GO/PAMAM as a High Capacity Adsorbent for Removal of Alizarin Red S: Selective Separation of Dyes

Rafi

Samiey

Cheng

2020

ACSi

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Adsorption of Alizarin Red S (ARS) on graphene oxide/poly(amidoamine) (GO/PAMAM) was studied at different ARS initial concentrations, temperatures, pHs, shaking rates and contact times. Adsorption sites of GO/PAMAM were phenolic –OH (Ph) group of GO and amine groups (–NH2, –NH+ 3 and –NHR+2) of PAMAM dendrimer moieties of GO/PAMAM. At pH = 2 and 318 K, maximum adsorption capacity (qe,max) of the adsorbent was 1275.2 mg g–1 which is one of the highest capacity in the literature. Thus, GO/PAMAM in this work acted as a superadsorbent for ARS. At the incipient of adsorption, ARS– molecules were adsorbed on Ph sites that was reaction-controlled step, (Ea = 114.5 kJ mol–1). Adsorption of ARS–on the remaining sites was diffusion–controlled. In alkaline media, two other types of ARS molecules were identified during that were adsorbed on Ph and –NH+ 3 sites. Further increasing the pH of the solution, decreased the number these two sites and yielded a reduced adsorption capacity (qe,max). Methylene blue (MB), thionine (Th), pyronin Y (PY), acridine orange (AO), methyl blue (MEB) and janus green (JG) dyes were selectively separated from their mixtures with ARS molecules using GO/PAMAM at pH of 2. The used adsorbent was recycled fficiently by using ethylenediamine very fast.

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Effect of adding CaCO3 and triple superphosphate fertilizer on growth and the content of alizarin of Rubia tinctorum L. in field conditions

Moghadami Rad,

Khavari-Nejad,

Saadatmand

et al. 2023

Europ.J.Hortic.Sci.

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Madder (Rubia tinctorum L.) is known as one of the most useful multipurpose plants. Madder root and rhizome contain alizarin. Pharmacological studies have shown that alizarin has a certain degree of selective inhibitory effects on cancer cells and it is used as a targeted drug for cancer treatment. Native knowledge of local farmers about the madder is that its roots grow better in calcareous soils, and its content of alizarin will be higher. Therefore, in this paper, the effects of different ratios of CaCO 3 (0, 20, 50, 100, and 150 kg ha -1 ) and triple-superphosphate fertilizer (0, 50, 100, and 150 kg ha -1 on physiological traits of madder were studied. Results revealed that certain physiological traits (total fresh weight, root fresh weight, root length, net assimilation rate, relative growth rate, and root relative growth rate) were increased under mediumlevel (50 kg ha -1 ) CaCO 3 and triple superphosphate treatments, but higher concentrations decreased the mentioned growth parameters, because the high concentrations of calcium carbonate caused the increase in concentrations, it negatively affected the results because they are complex compounds that cannot be used. These results suggest that low rates of CaCO 3 to highlight incremental stimulations of total fresh weight (79.42%) and alizarin content (26.72%) in madder roots and stimulate the interest for further studies and exploitation in the pharmaceutical industry.

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Use of Alizarin Red S as an Ion-Pair Reagent for the Spectrophotometric Assay of Fexofenadine in Pharmaceuticals and in Spiked Human Urine

Cited by 3 publications

References 23 publications

Ethno-Medicinal and Therapeutic Applications of Natural Anthraquinones: Recent Trends and Advancements

Ethno-Medicinal and Therapeutic Applications of Natural Anthraquinones: Recent Trends and Advancements

GO/PAMAM as a High Capacity Adsorbent for Removal of Alizarin Red S: Selective Separation of Dyes

Effect of adding CaCO3 and triple superphosphate fertilizer on growth and the content of alizarin of Rubia tinctorum L. in field conditions

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