Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Ashour, Safwan

doi:10.11648/j.mc.20170506.12

Cited by 6 publications

(4 citation statements)

References 34 publications

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“…An extractive-spectrophotometric method was used for the determination of Ulipristal acetate, an organic base. Exploitation of such reactions of naphthol blue black was a basis for estimation of different drugs containing amine group(s) [12][13][14][15][16][17][18] . The proposed method is centered on the reaction between organic base (Ulipristal acetate) and with an acidic dye (naphthol blue black) to produce an ion-association complex which can be extracted into organic solvent (chloroform) 19 .…”

Section: Resultsmentioning

confidence: 99%

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Extractive Spectrophotometric Determination of Ulipristal Acetate using Naphthol Blue Black

Gorumutchu¹,

Nadh²

2019

Rese. Jour. of Pharm. and Technol.

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Ulipristal acetate is used to treat uterine fibroids and for emergency birth control. The present study is a first report on development of a visible spectrophotometric method for determination of Ulipristal acetate present in bulk and tablet formulation. The method involves the sequential addition of HCl (0.1 N) and Napthol Blue Black solution to Ulipristal acetate. Cation formed on tertiary amine group of Ulipristal acetate attracts anion of naphthol blue black (an acid dye) to develop a coloured ion-association complex. From the aqueous phase, the chromophore is extractable into chloroform, which exhibits λmax at 640 nm. As per the existing guidelines of ICH, various parameters of the method were tested for validation. Regression analysis (r > 0.999) shows that the plotted calibration curve exhibits good linearity in the studied range of concentration (2.50-15.00 μg mL-1). The % recovery values falls in 99.80-100.72 range. %RSD results of both precision studies were observed in the range 0.007-0.560, indicating the satisfactory precision of the method. Low values of R.S.D. (< 1 %) were observed indicating that the proposed method is reproducible, accurate and precise. The proposed method can be used in quality control laboratories for routine analysis of Ulipristal acetate (bulk drug and pharmaceutical dosage forms) without requirement of expensive instruments.

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Section: Resultsmentioning

confidence: 99%

“…5). Based on the number of amine groups present on those pharmaceutical drug molecules, previous researchers reported the involvement of either 1:1 complex [12][13][14][15][16] or 2:1 complex [17][18].…”

Section: Chromophore Formation and Chemistrymentioning

confidence: 99%

Extractive Spectrophotometric Determination of Ulipristal Acetate using Naphthol Blue Black

Gorumutchu¹,

Nadh²

2019

Rese. Jour. of Pharm. and Technol.

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“…where A is the maximum observed absorbance and Am is the absorbance value when all the amount of drug is associated. CM is the mole concentration of drug at the maximum absorbance and n is the combination ratio of the ion-pair considered [54].…”

Section: Stability Constant (Kf) and The Standard Free Energy (G•) Of Coloured Speciesmentioning

confidence: 99%

A novel sensitive colorimetric determination of catecholamine drug in dosage form via oxidative coupling reaction with MBTH and potassium ferricyanide

Ashour

2021

Drug Anal. Res.

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A new and direct colorimetric method has been established for the determination of catecholamine (methyldopa, MD) in both pure form and in pharmaceutical formulations. The method is based on the oxidative coupling reaction of MD with 3-methyl-2-benzothiazolinone hydrazone hydrochloride monohydrate (MBTH) and potassium ferricyanide at pH 10.4 in aqueous medium to form an orange product that has a maximum absorption at 460 nm. Beer's law plot showed good correlation in the concentration range of 1.0−56.0 µg mL-1, with detection limit of 0.31 µg mL-1. Molar absorptivity for the above method was found to be 6.56×103 L mol-1 cm-1. All the measurements were carried out at 25 ± 1.0 °C, the formation constant (logKf) value of colored species is 9.48 and the standard free energy (DG‡) is − 54.09 KJ mol-1. This method was applied successfully to determination of MD in tablets and the results were compared with the USP method. Common excipients used as additives in tablets do not interfere in the proposed method. The method is accurate, precise and highly reproducible, while being simple, cheap and less time consuming and hence can be suitably applied for routine analysis of MD in bulk and dosage forms.

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“…Where A is the maximum observed absorbance and A m is the absorbance value when all the amount of drug is associated. C M is the mole concentration of drug at the maximum absorbance and n is the combination ratio of the ion-pair considered [37].…”

Section: Formation Constant (K F ) and The Standard Free Energy (∆G O ) Of Colored Speciesmentioning

confidence: 99%

Rapid Spectrophotometric Methods for the Determination of Moxifloxacin and Sildenafil in Pharmaceutical Preparations Based on Reaction with 4-Aminoantipyrine

Sensitive Extractional Colorimetric Analysis of Fexofenadine Hydrochloride and Irbesartan Bases Through Acid-Dye Complexation Using Naphthol Blue Black in Pure Form and Pharmaceuticals

Cited by 6 publications

References 34 publications

Extractive Spectrophotometric Determination of Ulipristal Acetate using Naphthol Blue Black

Extractive Spectrophotometric Determination of Ulipristal Acetate using Naphthol Blue Black

A novel sensitive colorimetric determination of catecholamine drug in dosage form via oxidative coupling reaction with MBTH and potassium ferricyanide

Rapid Spectrophotometric Methods for the Determination of Moxifloxacin and Sildenafil in Pharmaceutical Preparations Based on Reaction with 4-Aminoantipyrine

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