Uterine metastasis of lobular breast carcinoma under tamoxifen therapy: A case report

Awazu, Yuichiro; Fukuda, Takahiro; Imai, Kenji; Yamauchi, M.; Kasai, Mari; Ichimura, Tsuyoshi; Yasui, Toshihiro; Sumi, Toshiyuki

doi:10.3892/mco.2021.2428

Cited by 3 publications

(4 citation statements)

References 16 publications

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“…Because 7 (13%) of the patients in the current study reported having uterine metastases more than 10 years after the main tumor was treated, this warning should be in place throughout the duration of a breast cancer survivor's life. The patients reported by Franco-Márquez et al [37] and Awazu et al [49] were reported 30 years and 23 years, respectively, following their diagnosis of cancer.…”

Section: Discussionmentioning

confidence: 97%

“…Immunohistochemistry, in recent times, has evolved as a crucial technique in finding out the tissue of origin of the lesions [58]. GCDFP-15 (Gross cystic disease fluid protein-15) is a glycoprotein originally detected in the fluid from cystic mastopathy, and positive immunohistochemical staining for this biomarker proves the mammary origin of a lesion (49). GATA-3 is another highly conserved essential transcription factor that serves as a sensitive biomarker for the identification of metastatic breast cancer.…”

Section: Discussionmentioning

confidence: 99%

“…Similarly, negative staining for the CD10 biomarker indicates that the tumor did not originate from the uterine tissues. Positive staining for the cellular adhesion molecule E-cadherin suggests that the tumor is ductal carcinoma rather than lobular carcinoma (49) which underpins the discohesive pattern of the latter with cells arranged in single file and dispersed widely in the stroma. Mammaglobin is another 93-amino acid protein biomarker largely confined to breast tissue, and Han et al have developed antibodies to mammaglobin and found high sensitivity (84.3%) and specificity (85%) for the discrimination of breast cancer [60].…”

Section: Discussionmentioning

confidence: 99%

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Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

et al. 2023

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Breast cancer can metastasize to a wide range of organs, but reports about uterine metastases are rare. The current article systematically analyzes 55 patients reported in peer-reviewed literature from 2010–2022 with respect to nine variables, including: [i] age of the patient; [ii] clinical presentation of uterine metastasis; [iii] precise location of metastasis; [iv] primary (breast) cancer histopathology; [v] imaging modality utilized for detection of metastasis; [vi] timing of appearance of metastases: synchronous or metachronous; [vii] immunochemistry markers; [viii] management; and [ix] survival. Uterine metastases may appear in synchronous or metachronous fashion and may be asymptomatic or have symptoms like abnormal vaginal bleeding. Treatment of uterine metastases usually comprises of total abdominal hysterectomy with bilateral salpingo-oophorectomy along with chemotherapy. The long-term prognosis is unclear, but due to the development of metastases in other bodily parts, cases frequently have a poor outcome.

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Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

et al. 2023

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“…As a widely used oral hormone anti‐tumour drug, tamoxifen (TAM) can be used to treat ER‐positive breast cancer, 174 ovarian cancer 175 and so on. Researchers have investigated anti‐tumour activities of Ridaifens (RIDs), which are a series of synthesised TAM derivatives.…”

Section: Cpps and Anti‐cancer Cargoes Deliverymentioning

confidence: 99%

The role of cell‐penetrating peptides in potential anti‐cancer therapy

Zhou

Zou

Cheng

et al. 2022

Clinical & Translational Med

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Due to the complex physiological structure, microenvironment and multiple physiological barriers, traditional anti‐cancer drugs are severely restricted from reaching the tumour site. Cell‐penetrating peptides (CPPs) are typically made up of 5–30 amino acids, and can be utilised as molecular transporters to facilitate the passage of therapeutic drugs across physiological barriers. Up to now, CPPs have widely been used in many anti‐cancer treatment strategies, serving as an excellent potential choice for oncology treatment. However, their drawbacks, such as the lack of cell specificity, short duration of action, poor stability in vivo, compatibility problems (i.e. immunogenicity), poor therapeutic efficacy and formation of unwanted metabolites, have limited their further application in cancer treatment. The cellular uptake mechanisms of CPPs involve mainly endocytosis and direct penetration, but still remain highly controversial in academia. The CPPs‐based drug delivery strategy could be improved by clever design or chemical modifications to develop the next‐generation CPPs with enhanced cell penetration capability, stability and selectivity. In addition, some recent advances in targeted cell penetration that involve CPPs provide some new ideas to optimise CPPs.

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Breast cancer metastasis to endometrium: Case report and up-date of literature

Mohsenzadeh¹,

Chehregani²,

Hassan³

et al. 2023

J Gynecol Res Obstet

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Purpose: Cadmium is a heavy metal and is an important part of Diesel Exhaust Particles (DEPs). Cd in high concentrations exhibited detrimental effects and cause also increase the allergenicity of pollen grains. The aim of the research was to study the effects of Cd on the proteins and allergenicity of Petunia hybrida pollens. Methods: Petunia planets were cultured in a greenhouse and treated with various concentrations of Cadmium Chloride (400, 800 & 1200 µmol/L). The pollen was daily collected from the flowers of both experimental and control plants. Pollen extracts were prepared in PBS from control and Cd-treated plants and changes in protein banding profiles were compared by SDS-PAGE. Mice were sensitized by treatment of pollen extracts and AlOH3, as an adjuvant, three times. The allergenicity of pollen extracts was evaluated by skin test and the amount of IgE in the experimental animals. Results: Gel electrophoretic studies revealed that in the Cd-treated pollen grains, two new protein bands, 46 and 51 kDa, were observed that may have allergenicity. Results of serological tests showed the mean of wheal diameter and IgE level in animals that were sensitized to Cadmium chloride-treated pollen grains are more than the control. Conclusion: In recent years pollinosis is increased in polluted areas, especially DEP-polluted areas; the reason may be that Cadmium, as an important part of DEP, acts as an effective agent in the induction of the formation of detoxifying proteins which can also act as new allergens.

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Uterine metastasis of lobular breast carcinoma under tamoxifen therapy: A case report

Cited by 3 publications

References 16 publications

Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

Uterine Metastasis from Carcinoma of Breast – A Systematic Analysis

The role of cell‐penetrating peptides in potential anti‐cancer therapy

Breast cancer metastasis to endometrium: Case report and up-date of literature

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