Ustekinumab for the treatment of nail psoriasis in heavily treated psoriatic patients

Vitiello, Magalys; Tosti, Antonella; Abuchar, Adriana; Zaiac, Martin; Kerdel, Francisco A.

doi:10.1111/j.1365-4632.2011.05320.x

Cited by 30 publications

(17 citation statements)

References 10 publications

(24 reference statements)

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“…[99100] Recently, Patsatsi et al .,[99] conducted an open-label study to evaluate the role of ustekinumab in the treatment of nail psoriasis. Twenty-seven patients were taken and scheduled to receive subcutaneous injections of ustekinumab at a dose of 45 mg at baseline and week 4 and every 12 weeks.…”

Section: Treatment Of Nail Psoriasismentioning

confidence: 99%

Nail psoriasis: The journey so far

Dogra

Arora

2014

Indian J Dermatol

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Nail involvement is an extremely common feature of psoriasis and affects approximately 10-78% of psoriasis patients with 5-10% of patients having isolated nail psoriasis. However, it is often an overlooked feature in the management of nail psoriasis, despite the significant burden it places on the patients as a result of functional impairment of manual dexterity, pain, and psychological stress. Affected nail plates often thicken and crumble, and because they are very visible, patients tend to avoid normal day-to-day activities and social interactions. Importantly, 70-80% of patients with psoriatic arthritis have nail psoriasis. In this overview, we review the clinical manifestations of psoriasis affecting the nails, the common differential diagnosis of nail psoriasis, Nail Psoriasis Severity Index and the various diagnostic aids for diagnosing nail psoriasis especially, the cases with isolated nail involvement. We have also discussed the available treatment options, including the topical, physical, systemic, and biological modalities, in great detail in order to equip the present day dermatologist in dealing with a big clinical challenge, that is, management of nail psoriasis.

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Section: Treatment Of Nail Psoriasismentioning

confidence: 99%

Nail psoriasis: The journey so far

Dogra

Arora

2014

Indian J Dermatol

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“…Ustekinumab, an anti-IL-12/23 monoclonal antibody, was highly effective in treating nail psoriasis, when weight-based dosing was used 36,37,38,39,40 . Limited data show that IL-17 blockade with ixekinumab (> 75 mg subcutaneously) also appears to be effective 41 .…”

Section: Journal Of Rheumatologymentioning

confidence: 99%

Treatments for Nail Psoriasis: A Systematic Review by the GRAPPA Nail Psoriasis Work Group

Armstrong

Tuong²,

Löve³

et al. 2014

J Rheumatol

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Nail involvement in psoriatic diseases causes significant physical and functional disabilities. Evaluating, measuring, and treating nail involvement is important in improving the health outcomes and quality of life among patients with psoriasis and psoriatic arthritis (PsA). We performed a systematic analysis of the literature on nail psoriasis to help inform an update of treatment recommendations by the Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA).

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“…Two patients treated in combination with cyclosporine 100 mg b.i.d. had complete resolution of their nail psoriasis at week 12 [67]. After longer term safety and efficacy are proven, ustekinumab could become an effective option for treatment of nail psoriasis.…”

Section: Biologic Treatmentsmentioning

confidence: 99%

Treatment of Nail Psoriasis: Common Concepts and New Trends

Oram

Akkaya

2013

Dermatology Research and Practice

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The lifetime incidence of nail involvement in psoriatic patients is estimated to be 80–90%, and the nails can be affected in 10% to 55% of psoriatic patients. Psoriasis may also solely involve the nails, without any other skin findings, in which the treatment can be more challenging. Nail psoriasis may lead to considerable impairment in quality of life due to aesthetic concerns and more importantly limitations in daily activities resulting from the associated pain, which may be overlooked by the physicians. Several topical and systemic treatment modalities, as well as radiation and light systems, have been used in the treatment of nail psoriasis. In the last decade, the introduction of biologic agents and the utilization of laser systems have brought a new insight into the treatment of nail psoriasis. This paper focuses on the recent advances, as well as the conventional methods, in treating nail psoriasis in adults and children, in reference to an extensive literature search.

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Ustekinumab for the treatment of nail psoriasis in heavily treated psoriatic patients

Cited by 30 publications

References 10 publications

Nail psoriasis: The journey so far

Nail psoriasis: The journey so far

Treatments for Nail Psoriasis: A Systematic Review by the GRAPPA Nail Psoriasis Work Group

Treatment of Nail Psoriasis: Common Concepts and New Trends

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