2020
DOI: 10.1590/0103-1104202012706
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Uso de agrotóxicos e mortalidade por câncer em regiões de monoculturas

Abstract: RESUMO O uso de agrotóxicos na agricultura brasileira é um problema de saúde pública, dadas as contaminações no ambiente, em alimentos e as intoxicações resultantes do uso dessas substâncias. O objetivo deste artigo é investigar a distribuição espacial das áreas plantadas de lavouras e as taxas de mortalidade de alguns tipos de câncer: mama, colo do útero e próstata. Escolheram-se quatro estados brasileiros que possuem grande produção de commodities agrícolas a serem estudadas. Trata-se de um estudo ecológico … Show more

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Cited by 17 publications
(13 citation statements)
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“…Numerous in vivo studies (reviewed by Disner et al [ 77 ]) have recursively proven that exposure to pesticides, either isolated or in combination [ 78 ], affect human health due to their actions as carcinogens [ 79 , 80 , 81 , 82 , 83 , 84 ], neurotoxicants [ 85 , 86 , 87 , 88 ], endocrine disruptors, developmental toxicants [ 89 , 90 , 91 , 92 ], and metabolic toxicants [ 93 , 94 ].…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Numerous in vivo studies (reviewed by Disner et al [ 77 ]) have recursively proven that exposure to pesticides, either isolated or in combination [ 78 ], affect human health due to their actions as carcinogens [ 79 , 80 , 81 , 82 , 83 , 84 ], neurotoxicants [ 85 , 86 , 87 , 88 ], endocrine disruptors, developmental toxicants [ 89 , 90 , 91 , 92 ], and metabolic toxicants [ 93 , 94 ].…”
Section: Resultsmentioning
confidence: 99%
“…According to Smith et al [ 106 ], carcinogens generally exhibit more than 1 of the 10 main characteristics, such as genotoxicity, alteration of DNA repair systems or genomic instability, operate as electrophiles directly with or after metabolic activation, cause oxidative stress and chronic inflammation, immunosuppression, control of actions mediated by the receptor, induce immortalization or modify cell growth, induce cell death, or block the supply of nutrients and cause epigenetic changes [ 56 , 80 , 82 , 83 , 107 , 108 , 109 ]. Therefore, DNA damage and epigenetic alterations caused by chronic exposure to multiple pesticides are directly related to the development of several diseases, including different types of cancer.…”
Section: Resultsmentioning
confidence: 99%
“…Studies have pointed the relationship between exposure to pesticides and cancer morbidity and mortality in Brazil and in the state of Mato Grosso 23, [31][32][33][34][35] . Research that evaluated the use of pesticides and cancer mortality in monoculture regions in Brazil put Mato Grosso as a high concentration spot of mortality rates for breast, uterus and prostate cancer in the south of the state and surroundings of the municipalities with the highest estimated use of pesticides 23 .…”
Section: Discussionmentioning
confidence: 99%
“…O sistema convencional de plantio utiliza adubos químicos e agrotóxicos no cultivo das hortaliças. Esses insumos não orgânicos (adubos químicos, agrotóxicos e fertilizantes) possuem toxicidade que pode gerar danos ambientais e à saúde humana (Dutra et al, 2020). O uso de agrotóxicos pode ser um fator ambiental de destaque na ocorrência de diversas doenças como o câncer, pois os princípios ativos dessas substâncias químicas no organismo podem induzir a carcinogênese, reduzir as atividades de enzimas (acetilcolinesterase e butirilcolinesterase5), causam genotoxicidade, alterações genéticas, estresse oxidativo e imunossupressão, e podem agir como desreguladores endócrinos Szwarcwald & Damacena, 2020).…”
Section: Hortas E Suas Classificaçõesunclassified