Using target-specific aptamers to enhance the peroxidase-like activity of gold nanoclusters for colorimetric detection of tetracycline antibiotics

Zhang, Zhipeng; Yao, Tian; Huang, Pengcheng; Wu, Fang

doi:10.1016/j.talanta.2019.120342

Cited by 103 publications

(39 citation statements)

References 36 publications

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“…suffer from time consuming, high cost, complicated operations and poor sensitivity. The prosper of Au nanozymes with intrinsic POD-like activity provided possibility to tune the functionalization of existing methods in analyzing multiple antibiotics (e.g., doxycycline [ 325 ], kanamycin [ 61 ], tetracycline [ 329 ]). Kong et al [ 330 ] designed a novel photo-electrochemistry (PEC) biosensor for bleomycin (BLM) detection, which was natural antibiotics for Hodgkin's disease, cervical cancer therapy.…”

Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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Since the ferromagnetic (Fe3O4) nanoparticles were firstly reported to exert enzyme-like activity in 2007, extensive research progress in nanozymes has been made with deep investigation of diverse nanozymes and rapid development of related nanotechnologies. As promising alternatives for natural enzymes, nanozymes have broadened the way toward clinical medicine, food safety, environmental monitoring, and chemical production. The past decade has witnessed the rapid development of metal- and metal oxide-based nanozymes owing to their remarkable physicochemical properties in parallel with low cost, high stability, and easy storage. It is widely known that the deep study of catalytic activities and mechanism sheds significant influence on the applications of nanozymes. This review digs into the characteristics and intrinsic properties of metal- and metal oxide-based nanozymes, especially emphasizing their catalytic mechanism and recent applications in biological analysis, relieving inflammation, antibacterial, and cancer therapy. We also conclude the present challenges and provide insights into the future research of nanozymes constituted of metal and metal oxide nanomaterials.

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Section: Applications Of Metal- and Metal Oxide-based Nanozymesmentioning

confidence: 99%

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

et al. 2021

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“…Wu et al designed a new sensor based on gold nanoparticle (AuNP) aggregation and coordinated control of ss-DNA fragments to detect multiple antibiotics. The sensor has excellent selectivity and sensitivity for the separation and detection of TET and CAP [84,85]. Li [98].…”

Section: Application Of Gold Nanoparticles In Oral Biologymentioning

confidence: 99%

Antibacterial Properties of Functionalized Gold Nanoparticles and Their Application in Oral Biology

Huang

et al. 2020

Journal of Nanomaterials

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As bacterial resistance is becoming increasingly serious, the development of antibacterial nanomaterials is an effective method of solving this problem. Gold nanoparticles have good stability and excellent biocompatibility and are easily modified, and their antibacterial properties can be enhanced by changing their structure and size or adding ingredients. Gold nanoparticles are also excellent drug carriers that can improve the antibacterial effects of loaded antibacterial drugs. After being modified and combined with other antibacterial drugs, gold nanoparticles can also play a better antibacterial role for effective antibacterial strategies against some resistant bacteria. Gold nanoparticles have photothermal effects, and modified gold nanoparticles can be a good medium for photothermal treatments to kill bacteria. By adding functionally modified gold nanoparticles, many materials can obtain much needed antibacterial properties. Gold nanoparticles can also be combined with cations, low-temperature plasma, various surface ligands, and other potential antibacterial agents. In short, the antibacterial characteristics of functionalized gold nanoparticles demonstrate that they have considerable practical application value and provide more ideas to solve antibacterial problems. At the same time, the application of gold nanoparticles in oral biology is also increasing.

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“…The first exploited characteristic is the intrinsic peroxidase-like activity of AuNPs. Zhang et al (2020) developed a very simple colorimetric aptasensor for the detection of tetracycline in milk [138] based on the intrinsic peroxidase-like activity of gold nanoclusters (AuNCs). The aptamer is combined with AuNCs for two main reasons.…”

Section: Colorimetric Aptasensors Based On Peroxidase-like Activity Omentioning

confidence: 99%

The Growing Interest in Development of Innovative Optical Aptasensors for the Detection of Antimicrobial Residues in Food Products

Gaudin¹

2020

Biosensors

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The presence of antimicrobial residues in food-producing animals can lead to harmful effects on the consumer (e.g., allergies, antimicrobial resistance, toxicological effects) and cause issues in food transformation (i.e., cheese, yogurts production). Therefore, to control antimicrobial residues in food products of animal origin, screening methods are of utmost importance. Microbiological and immunological methods (e.g., ELISA, dipsticks) are conventional screening methods. Biosensors are an innovative solution for the development of more performant screening methods. Among the different kinds of biosensing elements (e.g., antibodies, aptamers, molecularly imprinted polymers (MIP), enzymes), aptamers for targeting antimicrobial residues are in continuous development since 2000. Therefore, this review has highlighted recent advances in the development of aptasensors, which present multiple advantages over immunosensors. Most of the aptasensors described in the literature for the detection of antimicrobial residues in animal-derived food products are either optical or electrochemical sensors. In this review, I have focused on optical aptasensors and showed how nanotechnologies (nanomaterials, micro/nanofluidics, and signal amplification techniques) largely contribute to the improvement of their performance (sensitivity, specificity, miniaturization, portability). Finally, I have explored different techniques to develop multiplex screening methods. Multiplex screening methods are necessary for the wide spectrum detection of antimicrobials authorized for animal treatment (i.e., having maximum residue limits).

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Using target-specific aptamers to enhance the peroxidase-like activity of gold nanoclusters for colorimetric detection of tetracycline antibiotics

Cited by 103 publications

References 36 publications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

A Review on Metal- and Metal Oxide-Based Nanozymes: Properties, Mechanisms, and Applications

Antibacterial Properties of Functionalized Gold Nanoparticles and Their Application in Oral Biology

The Growing Interest in Development of Innovative Optical Aptasensors for the Detection of Antimicrobial Residues in Food Products

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