Using of Coffee and Cardamom Mixture to Ameliorate Oxidative Stress Induced in γ-irradiated Rats

Abstract

Human exposure to ionizing radiation induced overproduction of free radicals leading to oxidative stress. This study aims to evaluate the possibility of using of coffee and cardamom mixture, as natural antioxidant compounds, to ameliorate the damage effect of oxidative stress. Phenolic contents in coffee and essential oils in cardamom were identified by using HPLC chromatography and GC/MS analysis. Four groups of adult male rats were used; the control group (A), the second group (B) received orally mixture extract of coffee and cardamom (60 mg/100g body weight) for 8 weeks, the third group (C) γ-irradiated (6 GY) and the fourth group (D) received orally mixture extract for 8 weeks and exposed to γ-irradiation at the 4th week. The results revealed that the administration of mixture extract of coffee and cardamom were significantly reduced the damage effect induced by γ-irradiation exposure. Accordingly, it could be concluded that, via the adjustment of the antioxidant status, decreasing the releasing of lipid peroxides and the subsequent amending of different biochemical parameters and some hormones, mixture of coffee and cardamom could ameliorate the hazardous effects of oxidative stress induced by irradiation exposure.

Evaluating the antimicrobial potential of green cardamom essential oil focusing on quorum sensing inhibition of Chromobacterium violaceum

“…Similarly, another study documented that 1,8-cineole (10.7%), a-terpinyl acetate (44.3%), a-terpineol (9.8%), linalool (8.6%) were the major compounds of essential oil (Singh et al 2008). Hamzaa and Osman (2012) characterized the green cardamom essential oil using GC-MS and found a-terpenyl acetate (60.65%), 1,8-cineol (13.63%), and limonene (7.12%) as major components. Recently, hydro-distilled cardamom essential oil obtained through Clevenger-type apparatus was analyzed by GC-MS and the results are in line with the current study as they reported the principle components were a-terpinyl acetate (40.7%), 1,8-cineole (25.6%), and linalool (6.3%) (Savan and Kucukbay 2013).…”

Green cardamom increases Sirtuin-1 and reduces inflammation in overweight or obese patients with non-alcoholic fatty liver disease: a double-blind randomized placebo-controlled clinical trial

“…The explained mechanisms in the improvement of the liver enzymes and the degree of fatty liver by cardamom include decrease of lipid peroxidation, increase of antioxidant capacity, cardamom active contents including phenols, polyphenols, minerals (Cu, Mn) [ 59 , 60 , 67 , 68 , 89 – 91 ], 1,8-cineol [ 92 ], and flavonoids [ 70 ].…”

Hypoglycemic effect of white (Morus alba L.) and black (Morus nigra L.) mulberry fruits in diabetic rat

“…These berries are not only used as fruits, but also have been used effectively as natural medicines to cure sore throat, fever, hypertension and anemia [16,17]. Moreover, white mulberry fruits widely distributed in Egyptian agriculture are used to protect from liver and kidney damage, strengthen the joints, improve eyesight, and have anti-aging and radio protective effects [15,18,19]. In addition, recent studies have reported that 1-deoxynojirimycin in white mulberry has anti-diabetic effects and it reduces postprandial blood glucose levels through inhibition of α-glucosidase and decrease of serum triglyceride levels [20,21].…”