Using compression calorimetry to characterize powder compaction behavior of pharmaceutical materials

Introducing a novel gravitation-based high-velocity compaction analysis method for pharmaceutical powders

“…Non-elastic energy, other than that amount included in the compact formation (or internal energy of the compact) consists of machine deformation, vibration, friction, heat and sound (Buckner et al 2010;Krok et al 2016;Stoianovici & Hurmuzlu 1996). Work is consumed and heat is released during powder deformation but some of this heat is reabsorbed during decompression phase.…”

Variations in Compaction Behaviour for Tablets of Different Size and Shape, Revealed by Small-Angle X-Ray Scattering

“…18 This could represent an important mechanism for energy dissipation and the mechanical heating that has been observed during compaction. [28][29][30][31][32] This phenomenon is widely known in the pharmaceutical industry, although it has received relatively little research attention. Moreover, since it could affect many aspects of the tabletting process, including compaction behaviour, strength, lubrication, friction, ejection forces and the crystal form or chemical stability of the drug, this merits further investigation.…”

Characterizing Compaction-Induced Thermodynamic Changes in a Common Pharmaceutical Excipient

“…The primary thermodynamic results come from heat of solution determinations, although true density, specific surface area, and moisture sorption measurements were performed as well. The materials and methods used in this study are described below, but more detail is available elsewhere 1,2…”

“…Compression calorimetry is a relatively unique approach to study pharmaceutical compaction. Thermodynamic characterization has shown value in fostering understanding of the processes, such as plastic deformation, underlying successful compact formation 1–7. The fundamental measurements made by the compression calorimeter are punch force, punch displacement, and compact temperature.…”