Characterizing Compaction-Induced Thermodynamic Changes in a Common Pharmaceutical Excipient

Wurster, Dale Eric; Buckner, Ira S.

doi:10.1002/jps.23226

Cited by 3 publications

(3 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To investigate the problems that occur during the compression, the loading stage is of high interest because, during this stage, the powder particles undergo plastic deformation, particle fragmentation, interparticle friction, and particle-wall friction [17][18][19][20][21][22][23][24], and the excess air in the interparticle pores escapes the compression die [25]. Hence, phenomena such as air entrapment [26], particle consolidation [25], and heat generation [19][20][21][22][23][24] were investigated during the loading phase of tableting. These phenomena are mainly investigated through modelling because of the difficulty of accessing the interior of the die during the loading phase [18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Hence, phenomena such as air entrapment [26], particle consolidation [25], and heat generation [19][20][21][22][23][24] were investigated during the loading phase of tableting. These phenomena are mainly investigated through modelling because of the difficulty of accessing the interior of the die during the loading phase [18][19][20][21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

“…Processes 2022, 10, 254 3 of 25 However, there are no simulation studies on the behavior of the powder bed water content during compression [18][19][20][21][22][23][24][25][26]. Therefore, this work aims to present the first step toward the moisture behavior simulation by showing the methods that can be used to estimate the input parameters, which are the moisture transport coefficients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Moisture Transport Coefficients Determination on a Model Pharmaceutical Tablet

2022

View full text Add to dashboard Cite

In this work, a novel methodology to determine moisture transport coefficients for MMC PH101 tablets is presented. Absolute permeability, moisture diffusion, moisture transfer, and water vapor permeability coefficients were estimated on compressed powder tablets produced with different compression pressures (20 MPa to 200 MPa with an interval of 20 MPa). The ASTM D6539 standard test was used to measure the absolute permeability. The moisture transfer coefficient was determined from measured absolute permeability. The moisture diffusion coefficient was obtained with the tablet average pore radius, which was determined with the water droplet penetration method. Descriptive and phenomenological models derived from the measurements were confronted with existing and adopted models, and a good agreement was found. The obtained models are of the function of the microstructural properties of the tablet (average pore radius and average porosity). The tablet average porosity was found to be the principal parameter that governs the behavior of the moisture transport coefficients. The findings of this study might be applicable to obtain a series of input parameters for modelling software, such as COMSOL Multiphysics®, to infer delamination, sticking, and failure propensity from the effect of moisture.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Moisture Transport Coefficients Determination on a Model Pharmaceutical Tablet

2022

View full text Add to dashboard Cite

show abstract

Investigating elastic relaxation effects on the optical properties of functionalised calcium carbonate compacts using optics-based Heckel analysis

Bawuah

Karttunen

Markl

et al. 2018

International Journal of Pharmaceutics

View full text Add to dashboard Cite

Heckel analysis is a widely used method for the characterisation of the compression behaviour of pharmaceutical samples during the preparation of solid dosage formulations. The present study introduces an optical version of the Heckel equation that is based on a combination of the conventional Heckel equation together with the linear relationship defined between the effective terahertz (THz) refractive index and the porosity of pharmaceutical tablets. The proposed optical Heckel equation allows us to, firstly, calculate the zero-porosity refractive index, and, secondly, predict the in-die development of the effective refractive index as a function of the compressive pressure during tablet compression. This was demonstrated for five batches of highly porous functionalised calcium carbonate (FCC) excipient compacts. The close match observed between the estimated in-die effective refractive index and the measured/out-of-die effective THz refractive index supports the validity of the proposed form of the equation. By comparing the measured and estimated in-die tablet properties, a clear change in the porosity and hence, the effective refractive index, due to post-compression elastic relaxation of the FCC compacts, has been observed. We have, therefore, proposed a THz-based compaction setup that will permit in-line monitoring of processes during tablet compression. We envisage that this new approach in tracking powder properties introduced in this preliminary study will lead to the onset of further extensive and detailed future studies.

show abstract