Using Chitosan or Chitosan Derivatives in Cancer Therapy

Shakil, Salman; Mahmud, Kazi Mustafa; Sayem, Mohammad; Niloy, Mahruba Sultana; Halder, Sajal Kumar; Hossen, Md. Sakib; Uddin, Md. Forhad; Hasan, Md. Ashraful

doi:10.3390/polysaccharides2040048

Cited by 38 publications

(24 citation statements)

References 144 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chitosan has amino functionalities that are useful for biopolymer modification [185]. Its biodegradability, biocompatibility, low immunogenicity, and non-toxicity mean that chitosan is used in delivery systems for various chemotherapeutic drugs [186]. Chitosan and its derivatives, such as carboxymethyl chitosan, sulfated chitosan, sulfated benzaldehyde chitosan, and polypyrrole-chitosan, have been shown to have anticancer activity in and of themselves [187][188][189][190].…”

Section: Calcium Phosphatementioning

confidence: 99%

Targeted Delivery Methods for Anticancer Drugs

Veselov

Nosyrev

Jicsinszky

et al. 2022

Cancers

View full text Add to dashboard Cite

Several drug-delivery systems have been reported on and often successfully applied in cancer therapy. Cell-targeted delivery can reduce the overall toxicity of cytotoxic drugs and increase their effectiveness and selectivity. Besides traditional liposomal and micellar formulations, various nanocarrier systems have recently become the focus of developmental interest. This review discusses the preparation and targeting techniques as well as the properties of several liposome-, micelle-, solid-lipid nanoparticle-, dendrimer-, gold-, and magnetic-nanoparticle-based delivery systems. Approaches for targeted drug delivery and systems for drug release under a range of stimuli are also discussed.

show abstract

Section: Calcium Phosphatementioning

confidence: 99%

Targeted Delivery Methods for Anticancer Drugs

Veselov

Nosyrev

Jicsinszky

et al. 2022

Cancers

View full text Add to dashboard Cite

show abstract

“…Chitosan, derived from chitin [233] (see Fig. 8) is one of the substances with the greatest abundance and distribution after cellulose [234].…”

Section: Removal Of Amoxicillin By Chitosanmentioning

confidence: 99%

Removal of Amoxicillin Through Different Methods, Emphasizing Removal by Biopolymers and Its Derivatives. An Overview

Aranda

Rivas

2022

J. Chil. Chem. Soc.

View full text Add to dashboard Cite

Although pharmaceutical compounds such as antibiotics have been of great help to animals and humans, the excessive use of them have become a global problem due to the resistance of pathogens to these drugs, for this reason a series of methods have been reported that we will see below that allow to remove efficiently, economically, and environmentally friendly compounds such as antibiotics.The aim of this overview is the removal of amoxicillin via different methods, emphasizing removal by biopolymers and its derivatives.

show abstract

“…Moreover, chitosan has gained attention as biomedical material [13,14] due to its multifaceted activities, such as anti-inflammatory [15], antibacterial [16], antitumoral [17][18][19], immunostimulatory [20], anti-hyperglycemic and anti-hyperlipidemic [21,22], antiulcer [23] and antioxidant [24,25] activities. The literature data highlight that this polymer can be formulated into various dosage forms: solutions, gels, solid mixtures, sponges, prolongedrelease tablets, pastes and nanoparticles, for different applications [26].…”

Section: Introductionmentioning

confidence: 99%

The Use of Chitosan-Coated Nanovesicles in Repairing Alcohol-Induced Damage of Liver Cells in Mice

et al. 2022

View full text Add to dashboard Cite

Background and Objectives In the past few decades, the studies concerning the natural polysaccharide chitosan have been centered on a new direction: its hepatoprotective action. The aim of our study was to evaluate the influence of previously designed chitosan lipid vesicles on the liver damage induced by alcohol consumption in mice. Materials and Methods The study involved the oral administration of substances in one daily dose as follows: Group 1 (control): water; Group 2 (control alcohol): 5% alcohol in water; Group 3 (CHIT): 0.1 mL/10 g body weight chitosan solution in animals treated with alcohol; Group 4 (CHIT-ves): 0.1 mL/10 g body chitosan vesicles in animals treated with alcohol; Group 5 (AcA): 200 mg/kg body ascorbic acid in animals treated with alcohol. In order to evaluate liver damage after alcohol consumption, the following hematological parameters were tested: the activity of alanine aminotransferase, aspartate aminotransferase and lactate dehydrogenase; serum values of urea and creatinine; the phagocytic capacity of polymorphonuclear neutrophilsin peripheral blood;serum opsonic capacity;bactericidal capacity of peritoneal macrophages; and the activity of malondialdehyde, glutathione peroxidase, superoxide dismutase and lactate dehydrogenase. Results and Conclusion The treatment with chitosan vesicles decreased liver enzyme activity and reduced the oxidative stress disturbances in alcoholic mice, thus repairing the hepatic functional and structural damages. These beneficial activities of chitosan vesicles were comparable with ascorbic acid effects in alcoholic mice.

show abstract

Using Chitosan or Chitosan Derivatives in Cancer Therapy

Cited by 38 publications

References 144 publications

Targeted Delivery Methods for Anticancer Drugs

Targeted Delivery Methods for Anticancer Drugs

Removal of Amoxicillin Through Different Methods, Emphasizing Removal by Biopolymers and Its Derivatives. An Overview

The Use of Chitosan-Coated Nanovesicles in Repairing Alcohol-Induced Damage of Liver Cells in Mice

Contact Info

Product

Resources

About