Targeted Delivery Methods for Anticancer Drugs

Veselov, Valery V.; Nosyrev, Alexander E.; Jicsinszky, László; Alyautdin, R. N.; Cravotto, Giancarlo

doi:10.3390/cancers14030622

Cited by 69 publications

(31 citation statements)

References 344 publications

(362 reference statements)

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“…The significantly enhanced cytotoxicity of DOX-loaded Hep/PQCS-PVA NPs against Hep G2 cells at pH 5.0 and with administration of mannitol was also observed (Figure 6d). This dually responsive NPs can react in a dynamic method when recognizing not only the acidic microenvironments in tumor sites but also exogenous stimulus of mannitol, whereas many studies of stimuli-responsive drug delivery based on CS focused on endogenous stimuli like pH value, redox condition, and enzyme [47][48][49].…”

Section: Discussionmentioning

confidence: 99%

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Qiao

Jiang

Fang

et al. 2022

IJMS

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In this work, we report the fabrication and functional demonstration of a kind of dually responsive nanoparticles (NPs) as a potential drug delivery vector. The pH value, corresponding to the acidic microenvironment at the tumor site, and mannitol, to the extracellular trigger agent, were employed as the dually responsive factors. The function of dual responses was achieved by breaking the dynamic covalent bonds between phenylboronic acid (PBA) groups and diols at low pH value (pH 5.0) and/or under the administration of mannitol, which triggered the decomposition of the complex NPs and the concomitant release of anticancer drug of doxorubicin (DOX) loaded inside the NPs. The NPs were composed of modified chitosan (PQCS) with quaternary ammonium and PBA groups on the side chains, heparin (Hep), and poly(vinyl alcohol) (PVA), in which quaternary ammonium groups offer the positive charge for the cell-internalization of NPs, PBA groups serve for the formation of dynamic bonds in responding to pH change and mannitol addition, PVA furnishes the NPs with diol groups for the interaction with PBA groups and the formation of dynamic NPS, and Hep plays the roles of reducing the cytotoxicity of highly positively-charged chitosan and forming of complex NPs for DOX up-loading. A three-step fabrication process of drug-loaded NPs was described, and the characterization results were comprehensively demonstrated. The sustained drug release from the drug-loaded NPs displayed obvious pH and mannitol dependence. More specifically, the cumulative DOX release was increased more than 1.5-fold at pH 5.0 with 20 mg mL−1 mannitol. Furthermore, the nanoparticles were manifested with effective antitumor efficient and apparently enhanced cytotoxicity in response to the acidic pH value and/or mannitol.

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Section: Discussionmentioning

confidence: 99%

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Qiao

Jiang

Fang

et al. 2022

IJMS

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“…The amphiphilicity of phospholipids can encapsulate hydrophilic and hydrophobic drugs in the water nucleus and lipid bilayer membrane of liposomes, respectively. Therefore, as drug delivery carriers, liposomes have been widely used in the eld of biomedicine [37]. Among different methods for preparing liposomal delivery system, active loading method, also known as remote loading method, is the direct loading of drug molecules into the prepared liposomes [38].…”

Section: Discussionmentioning

confidence: 99%

Encapsulation of a novel peptide derived from histatin-1 in liposomes against initial enamel caries in vitro and in vivo

Zhang

Chen

Liu

et al. 2023

Preprint

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Objectives: Biomimetic mineralization mediated by proteins and peptides is a promising strategy for enamel repair, and its specific application model needs more research. In this work, we exploited a liposomal delivery system for a novel peptide (DK5) derived from histatin-1 (DK5-Lips) as a new biomimetic mineralization strategy against initial enamel caries. Materials and methods: The DK5-Lips was prepared using calcium acetate gradient method and then the in vitro release, salivary stability and cytotoxicity were studied. Initial enamel caries was created in bovine enamel blocks and subjected to pH-cycling model treated with DK5-Lips. Surface microhardness testing, polarized light microscopy (PLM), and transverse microradiography (TMR) were analyzed. Then the biocompatibility of DK5-Lips was evaluated in the caries model of Sprague-Dawley rats, and the anti-caries effect was assessed using Micro-CT analysis, Keyes scores and PLM in vivo. Results: DK5-Lips provided a mean particle size of (97.63±4.94)nm and encapsulation efficiency of (61.46±1.44)%, exhibiting a sustained release profile, excellent stability in saliva, and no significant toxicity on human gingival fibroblasts (HGFs). DK5-Lips group had higher surface microhardness recovery, shallower caries depth and less mineral loss in bovine enamel. Animal experiments showed higher volume and density values of residual molar enamel, lower Keyes score, and shallower lesions depth of DK5-Lips group with good biocompatibility. Conclusion: As a safe and effective application model, DK5-Lips could significantly promote the remineralization of initial enamel caries both in vitro and in vivo. Clinical relevance: The potential of liposomes utilization as vehicle for oral delivery of functional peptides may provide a new way for enamel restoration.

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“…However, cancer is a complex disease; therefore, many types of cancer still have a high fatality rate. Targeted drug delivery in this context is highly critical for improving the survival rates of cancer patients with information that can ensure the accurate delivery of anticancer drugs (26). In addition, drug targeting helps to define the selective release of cancer drugs at the specific tumor site with a higher pharmacological impact.…”

Section: Targeted Drug Delivery Methods For Cancer Treatmentmentioning

confidence: 99%

Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges

Das

Chandra

2023

Front. Med. Technol.

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Cancer is a life-threatening disease, resulting in nearly 10 million deaths worldwide. There are various causes of cancer, and the prognostic information varies in each patient because of unique molecular signatures in the human body. However, genetic heterogeneity occurs due to different cancer types and changes in the neoplasms, which complicates the diagnosis and treatment. Targeted drug delivery is considered a pivotal contributor to precision medicine for cancer treatments as this method helps deliver medication to patients by systematically increasing the drug concentration on the targeted body parts. In such cases, nanoparticle-mediated drug delivery and the integration of artificial intelligence (AI) can help bridge the gap and enhance localized drug delivery systems capable of biomarker sensing. Diagnostic assays using nanoparticles (NPs) enable biomarker identification by accumulating in the specific cancer sites and ensuring accurate drug delivery planning. Integrating NPs for cancer targeting and AI can help devise sophisticated systems that further classify cancer types and understand complex disease patterns. Advanced AI algorithms can also help in biomarker detection, predicting different NP interactions of the targeted drug, and evaluating drug efficacy. Considering the advantages of the convergence of NPs and AI for targeted drug delivery, there has been significantly limited research focusing on the specific research theme, with most of the research being proposed on AI and drug discovery. Thus, the study's primary objective is to highlight the recent advances in drug delivery using NPs, and their impact on personalized treatment plans for cancer patients. In addition, a focal point of the study is also to highlight how integrating AI, and NPs can help address some of the existing challenges in drug delivery by conducting a collective survey.

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Targeted Delivery Methods for Anticancer Drugs

Cited by 69 publications

References 344 publications

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Dually Responsive Nanoparticles for Drug Delivery Based on Quaternized Chitosan

Encapsulation of a novel peptide derived from histatin-1 in liposomes against initial enamel caries in vitro and in vivo

Nanoparticles and convergence of artificial intelligence for targeted drug delivery for cancer therapy: Current progress and challenges

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